Citation Relationships



Rho YA, Prescott SA (2012) Identification of molecular pathologies sufficient to cause neuropathic excitability in primary somatosensory afferents using dynamical systems theory. PLoS Comput Biol 8:e1002524 [PubMed]

   Dorsal root ganglion (primary somatosensory) neurons (Rho & Prescott 2012)

References and models cited by this paper

References and models that cite this paper

Amir R, Liu CN, Kocsis JD, Devor M (2002) Oscillatory mechanism in primary sensory neurones. Brain 125:421-35 [PubMed]

Amir R, Michaelis M, Devor M (1999) Membrane potential oscillations in dorsal root ganglion neurons: role in normal electrogenesis and neuropathic pain. J Neurosci 19:8589-96 [PubMed]

Amir R, Michaelis M, Devor M (2002) Burst discharge in primary sensory neurons: triggered by subthreshold oscillations, maintained by depolarizing afterpotentials. J Neurosci 22:1187-98 [PubMed]

Baccei ML, Kocsis JD (2000) Voltage-gated calcium currents in axotomized adult rat cutaneous afferent neurons. J Neurophysiol 83:2227-38 [Journal] [PubMed]

Bauer CS, Tran-Van-Minh A, Kadurin I, Dolphin AC (2010) A new look at calcium channel a2d subunits. Curr Opin Neurobiol 20:563-71 [Journal] [PubMed]

Borisyuk A, Rinzel J (2005) Understanding neuronal dynamics by geometrical dissection of minimal models. Methods and Models in Neurophysics, Proceedings of Les Houches Summer School, how C:Gutkin B:Hansel D:Meunier C:Dalibard J, ed. pp.19

Campbell JN, Meyer RA (2006) Mechanisms of neuropathic pain. Neuron 52:77-92 [Journal] [PubMed]

Campbell JN, Raja SN, Meyer RA, Mackinnon SE (1988) Myelinated afferents signal the hyperalgesia associated with nerve injury. Pain 32:89-94 [PubMed]

Campbell JN,Basbaum AI,Dray A,Dubner R,Dworkin RH,et al (2006) Emerging Strategies for the Treatment of Neuropathic Pain

Cantrell AR, Catterall WA (2001) Neuromodulation of Na+ channels: an unexpected form of cellular plasticity. Nat Rev Neurosci 2:397-407 [Journal] [PubMed]

Choi JS, Cheng X, Foster E, Leffler A, Tyrrell L, Te Morsche RH, Eastman EM, Jansen HJ, Huehne K, Nau C, Dib-Hajj SD, Drenth JP, Waxman SG (2010) Alternative splicing may contribute to time-dependent manifestation of inherited erythromelalgia. Brain 133:1823-35 [Journal] [PubMed]

Choi JS, Waxman SG (2011) Physiological interactions between Na(v)1.7 and Na(v)1.8 sodium channels: a computer simulation study. J Neurophysiol 106:3173-84 [Journal] [PubMed]

Costigan M, Befort K, Karchewski L, Griffin RS, D'Urso D, Allchorne A, Sitarski J, Mannion JW, Pratt RE, Woolf CJ (2002) Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC Neurosci 3:16 [PubMed]

Costigan M, Scholz J, Woolf CJ (2009) Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci 32:1-32 [Journal] [PubMed]

Devor M (1991) Neuropathic pain and injured nerve: peripheral mechanisms. Br Med Bull 47:619-30 [PubMed]

Dorval AD, White JA (2005) Channel noise is essential for perithreshold oscillations in entorhinal stellate neurons. J Neurosci 25:10025-8 [Journal] [PubMed]

Edelman GM, Gally JA (2001) Degeneracy and complexity in biological systems. Proc Natl Acad Sci U S A 98:13763-8 [Journal] [PubMed]

Emery EC, Young GT, Berrocoso EM, Chen L, McNaughton PA (2011) HCN2 ion channels play a central role in inflammatory and neuropathic pain. Science 333:1462-6 [Journal] [PubMed]

Ermentrout GB (2002) Simulating, Analyzing, and Animating Dynamical System: A Guide to XPPAUT for Researchers and Students Society for Industrial and Applied Mathematics (SIAM)

Gold MS, Gebhart GF (2010) Nociceptor sensitization in pain pathogenesis. Nat Med 16:1248-57 [Journal] [PubMed]

Golomb D, Donner K, Shacham L, Shlosberg D, Amitai Y, Hansel D (2007) Mechanisms of firing patterns in fast-spiking cortical interneurons. PLoS Comput Biol 3:e156 [Journal] [PubMed]

   Fast-spiking cortical interneuron (Golomb et al. 2007) [Model]

Golowasch J, Goldman MS, Abbott LF, Marder E (2002) Failure of averaging in the construction of a conductance-based neuron model. J Neurophysiol 87:1129-31 [Journal] [PubMed]

Gracely RH, Lynch SA, Bennett GJ (1992) Painful neuropathy: altered central processing maintained dynamically by peripheral input. Pain 51:175-94 [PubMed]

Izhikevich EM (2007) Dynamical Systems in Neuroscience: The Geometry of Excitability and Bursting [Journal]

   Artificial neuron model (Izhikevich 2003, 2004, 2007) [Model]

Ji RR, Strichartz G (2004) Cell signaling and the genesis of neuropathic pain. Sci STKE 2004:reE14 [Journal] [PubMed]

Jian Z, Xing JL, Yang GS, Hu SJ (2004) A novel bursting mechanism of type a neurons in injured dorsal root ganglia. Neurosignals 13:150-6 [Journal] [PubMed]

Keller AF, Beggs S, Salter MW, De Koninck Y (2007) Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain. Mol Pain 3:27 [Journal] [PubMed]

Kepler TB, Abbott LF, Marder E (1992) Reduction of conductance-based neuron models. Biol Cybern 66:381-7 [PubMed]

Koltzenburg M, Torebjörk HE, Wahren LK (1994) Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain. Brain 117 ( Pt 3):579-91 [PubMed]

Kovalsky Y, Amir R, Devor M (2009) Simulation in sensory neurons reveals a key role for delayed Na+ current in subthreshold oscillations and ectopic discharge: implications for neuropathic pain. J Neurophysiol 102:1430-42 [Journal] [PubMed]

   Dorsal root ganglion (DRG) neuronal model (Kovalsky et al. 2009) [Model]

Liu CN, Devor M, Waxman SG, Kocsis JD (2002) Subthreshold oscillations induced by spinal nerve injury in dissociated muscle and cutaneous afferents of mouse DRG. J Neurophysiol 87:2009-17 [Journal] [PubMed]

Liu CN, Michaelis M, Amir R, Devor M (2000) Spinal nerve injury enhances subthreshold membrane potential oscillations in DRG neurons: relation to neuropathic pain. J Neurophysiol 84:205-15 [Journal] [PubMed]

Liu CN, Wall PD, Ben-Dor E, Michaelis M, Amir R, Devor M (2000) Tactile allodynia in the absence of C-fiber activation: altered firing properties of DRG neurons following spinal nerve injury. Pain 85:503-21 [PubMed]

Ma C, LaMotte RH (2005) Enhanced excitability of dissociated primary sensory neurons after chronic compression of the dorsal root ganglion in the rat. Pain 113:106-12 [Journal] [PubMed]

Ma C, LaMotte RH (2007) Multiple sites for generation of ectopic spontaneous activity in neurons of the chronically compressed dorsal root ganglion. J Neurosci 27:14059-68 [Journal] [PubMed]

Marder E (2011) Variability, compensation, and modulation in neurons and circuits. Proc Natl Acad Sci U S A 108 Suppl 3:15542-8 [Journal] [PubMed]

Mogil JS (2009) Animal models of pain: progress and challenges. Nat Rev Neurosci 10:283-94 [Journal] [PubMed]

Morris C, Lecar H (1981) Voltage oscillations in the barnacle giant muscle fiber. Biophys J 35:193-213 [Journal] [PubMed]

   Morris-Lecar model of the barnacle giant muscle fiber (Morris, Lecar 1981) [Model]

Nassar MA, Levato A, Stirling LC, Wood JN (2005) Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8. Mol Pain 1:24 [Journal] [PubMed]

Nassar MA, Stirling LC, Forlani G, Baker MD, Matthews EA, Dickenson AH, Wood JN (2004) Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. Proc Natl Acad Sci U S A 101:12706-11 [Journal] [PubMed]

Prescott SA, De Koninck Y (2003) Gain control of firing rate by shunting inhibition: roles of synaptic noise and dendritic saturation. Proc Natl Acad Sci U S A 100:2076-81 [Journal] [PubMed]

Prescott SA, De Koninck Y, Sejnowski TJ (2008) Biophysical basis for three distinct dynamical mechanisms of action potential initiation. PLoS Comput Biol 4:e1000198 [Journal] [PubMed]

   Dynamics of Spike Initiation (Prescott et al. 2008) [Model]

Prescott SA, Ratté S, De Koninck Y, Sejnowski TJ (2008) Pyramidal neurons switch from integrators in vitro to resonators under in vivo-like conditions. J Neurophysiol 100:3030-42 [Journal] [PubMed]

   Pyramidal neurons switch from integrators to resonators (Prescott et al. 2008) [Model]

Prescott SA, Sejnowski TJ (2008) Spike-rate coding and spike-time coding are affected oppositely by different adaptation mechanisms. J Neurosci 28:13649-61 [Journal] [PubMed]

Rinzel J, Ermentrout B (1998) Analysis of neural excitability and oscillations. Methods In Neuronal Modeling 2nd Edition, Segev I, Koch C, ed. pp.251

Rush AM, Dib-Hajj SD, Liu S, Cummins TR, Black JA, Waxman SG (2006) A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons. Proc Natl Acad Sci U S A 103:8245-50 [Journal] [PubMed]

Schulz DJ, Goaillard JM, Marder E (2006) Variable channel expression in identified single and electrically coupled neurons in different animals. Nat Neurosci 9:356-62 [Journal] [PubMed]

Song Y, Li HM, Xie RG, Yue ZF, Song XJ, Hu SJ, Xing JL (2012) Evoked bursting in injured Aß dorsal root ganglion neurons: a mechanism underlying tactile allodynia. Pain 153:657-65 [Journal] [PubMed]

Strogatz SH (1998) Nonlinear dynamics and chaos: with applications to physics, biology, chemistry, and engineering

Sutton KG, Martin DJ, Pinnock RD, Lee K, Scott RH (2002) Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones. Br J Pharmacol 135:257-65 [Journal] [PubMed]

Swensen AM, Bean BP (2005) Robustness of burst firing in dissociated purkinje neurons with acute or long-term reductions in sodium conductance. J Neurosci 25:3509-20 [Journal] [PubMed]

Torsney C, MacDermott AB (2006) Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord. J Neurosci 26:1833-43 [Journal] [PubMed]

Wang G, Thompson SM (2008) Maladaptive homeostatic plasticity in a rodent model of central pain syndrome: thalamic hyperexcitability after spinothalamic tract lesions. J Neurosci 28:11959-69 [Journal] [PubMed]

Wang JA, Lin W, Morris T, Banderali U, Juranka PF, Morris CE (2009) Membrane trauma and Na+ leak from Nav1.6 channels. Am J Physiol Cell Physiol 297:C823-34 [Journal] [PubMed]

Waxman SG, Kocsis JD, Black JA (1994) Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy. J Neurophysiol 72:466-70 [Journal] [PubMed]

Xing JL, Hu SJ, Long KP (2001) Subthreshold membrane potential oscillations of type A neurons in injured DRG. Brain Res 901:128-36 [PubMed]

Yang EK, Takimoto K, Hayashi Y, de Groat WC, Yoshimura N (2004) Altered expression of potassium channel subunit mRNA and alpha-dendrotoxin sensitivity of potassium currents in rat dorsal root ganglion neurons after axotomy. Neuroscience 123:867-74 [PubMed]

Ratté S, Zhu Y, Lee KY, Prescott SA (2014) Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain. Elife 3:e02370 [Journal] [PubMed]

   Criticality,degeneracy in injury-induced changes in primary afferent excitability (Ratte et al 2014) [Model]

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