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Hübel N, Hosseini-Zare MS, Žiburkus J, Ullah G (2017) The role of glutamate in neuronal ion homeostasis: A case study of spreading depolarization. PLoS Comput Biol 13:e1005804 [PubMed]

   The role of glutamate in neuronal ion homeostasis: spreading depolarization (Hubel et al 2017)

References and models cited by this paper

References and models that cite this paper

Allam SL, Ghaderi VS, Bouteiller JM, Legendre A, Ambert N, Greget R, Bischoff S, Baudry M, Berger TW (2012) A computational model to investigate astrocytic glutamate uptake influence on synaptic transmission and neuronal spiking. Front Comput Neurosci 6:70 [Journal] [PubMed]

Ayata C, Lauritzen M (2015) Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature. Physiol Rev 95:953-93 [Journal] [PubMed]

Azevedo FA, Carvalho LR, Grinberg LT, Farfel JM, Ferretti RE, Leite RE, Jacob Filho W, Lent R, Herculano-Houzel S (2009) Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain. J Comp Neurol 513:532-41 [Journal] [PubMed]

Barreto E, Cressman JR (2011) Ion concentration dynamics as a mechanism for neuronal bursting. J Biol Phys 37:361-73 [Journal] [PubMed]

   Ion concentration dynamics as a mechanism for neuronal bursting (Barreto & Cressman 2011) [Model]

Basarsky TA, Feighan D, MacVicar BA (1999) Glutamate release through volume-activated channels during spreading depression. J Neurosci 19:6439-45 [PubMed]

Baszczak M, Kasicki S (2005) A single compartment neuron model with activity-dependent conductances during NMDA induced activity. Acta Neurobiol Exp (Wars) 65:183-90 [PubMed]

Benarroch EE (2010) Glutamate transporters: diversity, function, and involvement in neurologic disease. Neurology 74:259-64 [Journal] [PubMed]

Boie S, Kirk V, Sneyd J, Wechselberger M (2016) Effects of quasi-steady-state reduction on biophysical models with oscillations. J Theor Biol 393:16-31 [Journal] [PubMed]

Bøttger P, Glerup S, Gesslein B, Illarionova NB, Isaksen TJ, Heuck A, Clausen BH, Füchtbauer EM, Gramsbergen JB, Gunnarson E, Aperia A, Lauritzen M, Lambertsen KL, Nissen P, Lykke-Hartmann K (2016) Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model. Sci Rep 6:22047 [Journal] [PubMed]

Bozzo L, Chatton JY (2010) Inhibitory effects of (2S, 3S)-3-[3-[4-(trifluoromethyl)benzoylamino]benzyloxy]aspartate (TFB-TBOA) on the astrocytic sodium responses to glutamate. Brain Res 1316:27-34 [Journal] [PubMed]

Brisson CD, Andrew RD (2012) A neuronal population in hypothalamus that dramatically resists acute ischemic injury compared to neocortex. J Neurophysiol 108:419-30 [Journal] [PubMed]

Bruns D, Jahn R (1995) Real-time measurement of transmitter release from single synaptic vesicles. Nature 377:62-5 [Journal] [PubMed]

BURES J (1957) The ontogenetic development of steady potential differences in the cerebral cortex in animals. Electroencephalogr Clin Neurophysiol 9:121-30 [PubMed]

Burger PM, Mehl E, Cameron PL, Maycox PR, Baumert M, Lottspeich F, De Camilli P, Jahn R (1989) Synaptic vesicles immunoisolated from rat cerebral cortex contain high levels of glutamate. Neuron 3:715-20 [PubMed]

Capuani C, Melone M, Tottene A, Bragina L, Crivellaro G, Santello M, Casari G, Conti F, Pietrobon D (2016) Defective glutamate and K+ clearance by cortical astrocytes in familial hemiplegic migraine type 2. EMBO Mol Med 8:967-86 [Journal] [PubMed]

Chang JC, Brennan KC, He D, Huang H, Miura RM, Wilson PL, Wylie JJ (2013) A mathematical model of the metabolic and perfusion effects on cortical spreading depression. PLoS One 8:e70469 [Journal] [PubMed]

Chuquet J, Hollender L, Nimchinsky EA (2007) High-resolution in vivo imaging of the neurovascular unit during spreading depression. J Neurosci 27:4036-44 [Journal] [PubMed]

COSBID (2002) Co-operative studies on brain injury depolarizations. URL http://www.cosbid.org

Cressman JR, Ullah G, Ziburkus J, Schiff SJ, Barreto E (2009) The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states: I. Single neuron dynamics. J Comput Neurosci 26:159-70 [Journal] [PubMed]

   Single neuron with dynamic ion concentrations (Cressman et al. 2009) [Model]

Cressman JR, Ullah G, Ziburkus J, Schiff SJ, Barreto E (2011) Erratum to: The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states: I. Single neuron dynamics. J Comput Neurosci 30:781

Czéh G, Aitken PG, Somjen GG (1993) Membrane currents in CA1 pyramidal cells during spreading depression (SD) and SD-like hypoxic depolarization. Brain Res 632:195-208 [PubMed]

Dahlem MA, Schumacher J, Hübel N (2014) Linking a genetic defect in migraine to spreading depression in a computational model. PeerJ 2:e379 [Journal] [PubMed]

   Spreading depression model for FHM3 with Nav1.1 mutation (Dahlem et al. 2014) [Model]

de Luca B, Bures J (1977) Development of cortical spreading depression and of its transition to the caudate nucleus in rats. Dev Psychobiol 10:289-97 [Journal] [PubMed]

Destexhe A, Mainen ZF, Sejnowski TJ (1998) Kinetic models of synaptic transmission Methods In Neuronal Modeling, Koch C:Segev I, ed. pp.1

   Kinetic synaptic models applicable to building networks (Destexhe et al 1998) [Model]

Doedel EJ,Oldeman BE (2007) Auto-07P: Continuation and bifurcation software for ordinary differential equations

Dreier JP (2011) The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease. Nat Med 17:439-47 [Journal] [PubMed]

Dreier JP, Fabricius M, Ayata C, Sakowitz OW, William Shuttleworth C, Dohmen C, Graf R, Vajkoczy P, Helbok R, Suzuki M, Schiefecker AJ, Major S, Winkler MK, Kang EJ, Milakara D, Oliveira-Ferreira AI, Reiffurth C, Revankar GS, Sugimoto K, Dengler NF, Hecht N, Foreman B, Feyen B, Kondziella D, Friberg CK, Piilgaard H, Rosenthal ES, Westover MB, Maslarova A, Santos E, Hertle D, Sánchez-Porras R, Jewell SL, Balança B, Platz J, Hinzman JM, Lückl J, Schoknecht K, Schöll M, Drenckhahn C, Feuerstein D, Eriksen N, Horst V, Bretz JS, Jahnke P, Scheel M, Bohner G, Rostrup E, Pakkenberg B, Heinemann U, Claassen J, Carlson AP, Kowoll CM, Lublinsky S, Chassidim Y, Shelef I, Friedman A, Brinker G, Reiner M, Kirov SA, Andrew RD, Farkas E, Güresir E, Vatter H, Chung LS, Brennan KC, Lieutaud T, Marinesco S, Maas AI, Sahuquillo J, Dahlem MA, Richter F, Herreras O, Boutelle MG, Okonkwo DO, Witte OW (2017) Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group. J Cereb Blood Flow Metab 37:1595-1625 [Journal] [PubMed]

Dreier JP, Major S, Manning A, Woitzik J, Drenckhahn C, Steinbrink J, Tolias C, Oliveira-Ferreira AI, Fabricius M, Hartings JA, Vajkoczy P, Lauritzen M, Dirnagl U, Bohner G, Strong AJ, COSBID study group (2009) Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage. Brain 132:1866-81 [Journal] [PubMed]

Dreier JP, Reiffurth C (2015) The stroke-migraine depolarization continuum. Neuron 86:902-922 [Journal] [PubMed]

Fabricius M, Fuhr S, Willumsen L, Dreier JP, Bhatia R, Boutelle MG, Hartings JA, Bullock R, Strong AJ, Lauritzen M (2008) Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brain. Clin Neurophysiol 119:1973-84 [Journal] [PubMed]

Gauck V, Jaeger D (2003) The contribution of NMDA and AMPA conductances to the control of spiking in neurons of the deep cerebellar nuclei. J Neurosci 23:8109-18 [PubMed]

Gu F, Hazra A, Aulakh A, Žiburkus J (2014) Purinergic control of hippocampal circuit hyperexcitability in Dravet syndrome. Epilepsia 55:245-55 [Journal] [PubMed]

Hadjikhani N, Sanchez Del Rio M, Wu O, Schwartz D, Bakker D, Fischl B, Kwong KK, Cutrer FM, Rosen BR, Tootell RB, Sorensen AG, Moskowitz MA (2001) Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci U S A 98:4687-92 [Journal] [PubMed]

Haglund MM, Schwartzkroin PA (1990) Role of Na-K pump potassium regulation and IPSPs in seizures and spreading depression in immature rabbit hippocampal slices. J Neurophysiol 63:225-39 [Journal] [PubMed]

Hansen AJ, Nedergaard M (1988) Brain ion homeostasis in cerebral ischemia. Neurochem Pathol 9:195-209 [PubMed]

Hansen AJ, Zeuthen T (1981) Extracellular ion concentrations during spreading depression and ischemia in the rat brain cortex. Acta Physiol Scand 113:437-45 [Journal] [PubMed]

Hartings JA, Shuttleworth CW, Kirov SA, Ayata C, Hinzman JM, Foreman B, Andrew RD, Boutelle MG, Brennan KC, Carlson AP, Dahlem MA, Drenckhahn C, Dohmen C, Fabricius M, Farkas E, Feuerstein D, Graf R, Helbok R, Lauritzen M, Major S, Oliveira-Ferreira AI, Richter F, Rosenthal ES, Sakowitz OW, Sánchez-Porras R, Santos E, Schöll M, Strong AJ, Urbach A, Westover MB, Winkler MK, Witte OW, Woitzik J, Dreier JP (2017) The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão's legacy. J Cereb Blood Flow Metab 37:1571-1594 [Journal] [PubMed]

Hertle DN, Dreier JP, Woitzik J, Hartings JA, Bullock R, Okonkwo DO, Shutter LA, Vidgeon S, Strong AJ, Kowoll C, Dohmen C, Diedler J, Veltkamp R, Bruckner T, Unterberg AW, Sakowitz OW, Cooperative Study of Brain Injury Depolarizations (COSBID) (2012) Effect of analgesics and sedatives on the occurrence of spreading depolarizations accompanying acute brain injury. Brain 135:2390-8 [Journal] [PubMed]

Hines ML, Morse T, Migliore M, Carnevale NT, Shepherd GM (2004) ModelDB: A Database to Support Computational Neuroscience. J Comput Neurosci 17:7-11 [Journal] [PubMed]

Hinzman JM, DiNapoli VA, Mahoney EJ, Gerhardt GA, Hartings JA (2015) Spreading depolarizations mediate excitotoxicity in the development of acute cortical lesions. Exp Neurol 267:243-53 [Journal] [PubMed]

Holmes WR (1995) Modeling the effect of glutamate diffusion and uptake on NMDA and non-NMDA receptor saturation. Biophys J 69:1734-47 [Journal] [PubMed]

Holmseth S, Dehnes Y, Huang YH, Follin-Arbelet VV, Grutle NJ, Mylonakou MN, Plachez C, Zhou Y, Furness DN, Bergles DE, Lehre KP, Danbolt NC (2012) The density of EAAC1 (EAAT3) glutamate transporters expressed by neurons in the mammalian CNS. J Neurosci 32:6000-13 [Journal] [PubMed]

Hosseini-Zare MS, Gu F, Abdulla A, Powell S, Žiburkus J (2017) Effects of experimental traumatic brain injury and impaired glutamate transport on cortical spreading depression. Exp Neurol 295:155-161 [Journal] [PubMed]

Hoyte L, Kaur J, Buchan AM (2004) Lost in translation: taking neuroprotection from animal models to clinical trials. Exp Neurol 188:200-4 [Journal] [PubMed]

Hübel N, Andrew RD, Ullah G (2016) Large extracellular space leads to neuronal susceptibility to ischemic injury in a Na+/K+ pumps-dependent manner. J Comput Neurosci 40:177-92 [Journal] [PubMed]

   Anoxic depolarization, recovery: effect of brain regions and extracellular space (Hubel et al. 2016) [Model]

Hübel N, Dahlem MA (2014) Dynamics from seconds to hours in Hodgkin-Huxley model with time-dependent ion concentrations and buffer reservoirs. PLoS Comput Biol 10:e1003941 [Journal] [PubMed]

   Hodgkin-Huxley with dynamic ion concentrations (Hubel and Dahlem, 2014) [Model]

Hübel N, Schöll E, Dahlem MA (2014) Bistable dynamics underlying excitability of ion homeostasis in neuron models. PLoS Comput Biol 10:e1003551 [Journal] [PubMed]

Hübel N, Ullah G (2016) Anions Govern Cell Volume: A Case Study of Relative Astrocytic and Neuronal Swelling in Spreading Depolarization. PLoS One 11:e0147060 [Journal] [PubMed]

   An ion-based model for swelling of neurons and astrocytes (Hubel & Ullah 2016) [Model]

Ingram J, Zhang C, Cressman JR, Hazra A, Wei Y, Koo YE, Žiburkus J, Kopelman R, Xu J, Schiff SJ (2014) Oxygen and seizure dynamics: I. Experiments. J Neurophysiol 112:205-12 [Journal] [PubMed]

Kager H, Wadman WJ, Somjen GG (2000) Simulated seizures and spreading depression in a neuron model incorporating interstitial space and ion concentrations. J Neurophysiol 84:495-512 [Journal] [PubMed]

Kager H, Wadman WJ, Somjen GG (2002) Conditions for the triggering of spreading depression studied with computer simulations. J Neurophysiol 88:2700-12 [Journal] [PubMed]

Kager H, Wadman WJ, Somjen GG (2007) Seizure-like afterdischarges simulated in a model neuron. J Comput Neurosci 22:105-28 [Journal] [PubMed]

Kandell ER, Schwartz JH, Jessell TH (1991) Principles of Neural Science :582-583

Karatas H, Erdener SE, Gursoy-Ozdemir Y, Lule S, Eren-Koçak E, Sen ZD, Dalkara T (2013) Spreading depression triggers headache by activating neuronal Panx1 channels. Science 339:1092-5 [Journal] [PubMed]

Keener J, Sneyd J (2009) Mathematical Physiology I: Cellular Physiology

Kimelberg HK (2000) Cell volume in the CNS: regulation and implications for nervous system function and pathology Neuroscientist 6:14-25

Kimelberg HK (2005) Astrocytic swelling in cerebral ischemia as a possible cause of injury and target for therapy. Glia 50:389-97 [Journal] [PubMed]

Larrosa B, Pastor J, López-Aguado L, Herreras O (2006) A role for glutamate and glia in the fast network oscillations preceding spreading depression. Neuroscience 141:1057-68 [Journal] [PubMed]

Lauderback CM, Hackett JM, Huang FF, Keller JN, Szweda LI, Markesbery WR, Butterfield DA (2001) The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Abeta1-42. J Neurochem 78:413-6 [PubMed]

Lauritzen M (1987) Cortical spreading depression as a putative migraine mechanism Trends Neurosci 10:8-13

Lauritzen M, Dreier JP, Fabricius M, Hartings JA, Graf R, Strong AJ (2011) Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury. J Cereb Blood Flow Metab 31:17-35 [Journal] [PubMed]

Leão AAP (1944) Spreading depression of activity in the cerebral cortex J Neurophysiol 7:359-390

Leão AAP,Morison RS (1945) Propagation of cortical spreading depression J Neurophysiol 1:33-45

Lee JM, Zipfel GJ, Choi DW (1999) The changing landscape of ischaemic brain injury mechanisms. Nature 399:A7-14 [PubMed]

Lehre KP, Danbolt NC (1998) The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain. J Neurosci 18:8751-7 [PubMed]

Lipski J, Wan CK, Bai JZ, Pi R, Li D, Donnelly D (2007) Neuroprotective potential of ceftriaxone in in vitro models of stroke. Neuroscience 146:617-29 [Journal] [PubMed]

Lo EH (2008) A new penumbra: transitioning from injury into repair after stroke. Nat Med 14:497-500 [Journal] [PubMed]

Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, Chan P, Verkman AS (2000) Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med 6:159-63 [Journal] [PubMed]

Olesen J, Larsen B, Lauritzen M (1981) Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol 9:344-52 [Journal] [PubMed]

Østby I, Øyehaug L, Einevoll GT, Nagelhus EA, Plahte E, Zeuthen T, Lloyd CM, Ottersen OP, Omholt SW (2009) Astrocytic mechanisms explaining neural-activity-induced shrinkage of extraneuronal space. PLoS Comput Biol 5:e1000272 [Journal] [PubMed]

   Mechanisms of extraneuronal space shrinkage (Ostby et al 2009) [Model]

Pietrobon D, Moskowitz MA (2013) Pathophysiology of migraine. Annu Rev Physiol 75:365-91 [Journal] [PubMed]

Pietrobon D, Moskowitz MA (2014) Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations. Nat Rev Neurosci 15:379-93 [Journal] [PubMed]

Risher WC, Andrew RD, Kirov SA (2009) Real-time passive volume responses of astrocytes to acute osmotic and ischemic stress in cortical slices and in vivo revealed by two-photon microscopy. Glia 57:207-21 [Journal] [PubMed]

Riveros N, Fiedler J, Lagos N, Muñoz C, Orrego F (1986) Glutamate in rat brain cortex synaptic vesicles: influence of the vesicle isolation procedure. Brain Res 386:405-8 [PubMed]

Rogawski MA (2010) Migraine and epilepsy: Shared mechanisms? Epilepsia 51:80-80

Rogawski MA (2012) Migraine and epilepsy–shared mechanisms within the family of episodic disorders Jasper’s Basic Mechanisms of the Epilepsies, Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, ed.

Rossi DJ, Oshima T, Attwell D (2000) Glutamate release in severe brain ischaemia is mainly by reversed uptake. Nature 403:316-21 [Journal] [PubMed]

Rothstein JD, Dykes-Hoberg M, Pardo CA, Bristol LA, Jin L, Kuncl RW, Kanai Y, Hediger MA, Wang Y, Schielke JP, Welty DF (1996) Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16:675-86 [PubMed]

Rothstein JD, Patel S, Regan MR, Haenggeli C, Huang YH, Bergles DE, Jin L, Dykes Hoberg M, Vidensky S, Chung DS, Toan SV, Bruijn LI, Su ZZ, Gupta P, Fisher PB (2005) Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 433:73-7 [Journal] [PubMed]

Rothstein JD, Van Kammen M, Levey AI, Martin LJ, Kuncl RW (1995) Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann Neurol 38:73-84 [Journal] [PubMed]

Rusakov DA (2001) The role of perisynaptic glial sheaths in glutamate spillover and extracellular Ca(2+) depletion. Biophys J 81:1947-59 [Journal] [PubMed]

Rusakov DA, Kullmann DM (1998) Extrasynaptic glutamate diffusion in the hippocampus: ultrastructural constraints, uptake, and receptor activation. J Neurosci 18:3158-70 [PubMed]

Sakowitz OW, Kiening KL, Krajewski KL, Sarrafzadeh AS, Fabricius M, Strong AJ, Unterberg AW, Dreier JP (2009) Preliminary evidence that ketamine inhibits spreading depolarizations in acute human brain injury. Stroke 40:e519-22 [Journal] [PubMed]

Sánchez-Porras R, Santos E, Schöll M, Stock C, Zheng Z, Schiebel P, Orakcioglu B, Unterberg AW, Sakowitz OW (2014) The effect of ketamine on optical and electrical characteristics of spreading depolarizations in gyrencephalic swine cortex. Neuropharmacology 84:52-61 [Journal] [PubMed]

Seidel JL, Escartin C, Ayata C, Bonvento G, Shuttleworth CW (2016) Multifaceted roles for astrocytes in spreading depolarization: A target for limiting spreading depolarization in acute brain injury? Glia 64:5-20 [Journal] [PubMed]

Sepkuty JP, Cohen AS, Eccles C, Rafiq A, Behar K, Ganel R, Coulter DA, Rothstein JD (2002) A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy. J Neurosci 22:6372-9 [Journal] [PubMed]

Shandilya SG,Timme M (2011) Inferring network topology from complex dynamics New Journal of Physical 13(1):013,004

Shapiro BE (2001) Osmotic forces and gap junctions in spreading depression: a computational model. J Comput Neurosci 10:99-120 [PubMed]

Shimamoto K, Sakai R, Takaoka K, Yumoto N, Nakajima T, Amara SG, Shigeri Y (2004) Characterization of novel L-threo-beta-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters. Mol Pharmacol 65:1008-15 [Journal] [PubMed]

Silchenko AN, Tass PA (2008) Computational modeling of paroxysmal depolarization shifts in neurons induced by the glutamate release from astrocytes. Biol Cybern 98:61-74 [Journal] [PubMed]

Somjen GG (2004) Ions in the brain: Normal function, seizures and stroke

Szatkowski M, Barbour B, Attwell D (1990) Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake. Nature 348:443-6 [Journal] [PubMed]

Tanaka K, Watase K, Manabe T, Yamada K, Watanabe M, Takahashi K, Iwama H, Nishikawa T, Ichihara N, Kikuchi T, Okuyama S, Kawashima N, Hori S, Takimoto M, Wada K (1997) Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276:1699-702 [PubMed]

Ullah G, Cressman JR, Barreto E, Schiff SJ (2009) The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states. II. Network and glial dynamics. J Comput Neurosci 26:171-83 [Journal] [PubMed]

   Network model with dynamic ion concentrations (Ullah et al. 2009) [Model]

Ullah G, Schiff SJ (2009) Tracking and control of neuronal Hodgkin-Huxley dynamics. Phys Rev E Stat Nonlin Soft Matter Phys 79:040901 [Journal] [PubMed]

Ullah G, Schiff SJ (2010) Assimilating seizure dynamics. PLoS Comput Biol 6:e1000776 [Journal] [PubMed]

Ullah G, Wei Y, Dahlem MA, Wechselberger M, Schiff SJ (2015) The Role of Cell Volume in the Dynamics of Seizure, Spreading Depression, and Anoxic Depolarization. PLoS Comput Biol 11:e1004414 [Journal] [PubMed]

Volman V, Bazhenov M, Sejnowski TJ (2012) Computational models of neuron-astrocyte interaction in epilepsy. Front Comput Neurosci 6:58 [Journal] [PubMed]

Vyskocil F, Kritz N, Bures J (1972) Potassium-selective microelectrodes used for measuring the extracellular brain potassium during spreading depression and anoxic depolarization in rats. Brain Res 39:255-9 [PubMed]

Watase K, Hashimoto K, Kano M, Yamada K, Watanabe M, Inoue Y, Okuyama S, Sakagawa T, Ogawa S, Kawashima N, Hori S, Takimoto M, Wada K, Tanaka K (1998) Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice. Eur J Neurosci 10:976-88 [PubMed]

Wei Y, Ullah G, Ingram J, Schiff SJ (2014) Oxygen and Seizure Dynamics: II. Computational Modeling. J Neurophysiol [Journal] [PubMed]

Wei Y, Ullah G, Schiff SJ (2014) Unification of neuronal spikes, seizures, and spreading depression. J Neurosci 34:11733-43 [Journal] [PubMed]

Witthoft A, Filosa JA, Karniadakis GE (2013) Potassium buffering in the neurovascular unit: models and sensitivity analysis. Biophys J 105:2046-54 [Journal] [PubMed]

Yao C, Zhan M (2010) Signal transmission by vibrational resonance in one-way coupled bistable systems. Phys Rev E Stat Nonlin Soft Matter Phys 81:061129 [Journal] [PubMed]

Ye ZC, Rothstein JD, Sontheimer H (1999) Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange. J Neurosci 19:10767-77 [PubMed]

Young D, Lawlor PA, Leone P, Dragunow M, During MJ (1999) Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective. Nat Med 5:448-53 [Journal] [PubMed]

Zandt BJ, ten Haken B, van Dijk JG, van Putten MJ (2011) Neural dynamics during anoxia and the "wave of death". PLoS One 6:e22127 [Journal] [PubMed]

   Single neuron with ion concentrations to model anoxic depolarization (Zandt et al. 2011) [Model]

Zhang Z, Tao Z, Gameiro A, Barcelona S, Braams S, Rauen T, Grewer C (2007) Transport direction determines the kinetics of substrate transport by the glutamate transporter EAAC1. Proc Natl Acad Sci U S A 104:18025-30 [Journal] [PubMed]

Zhou N, Rungta RL, Malik A, Han H, Wu DC, MacVicar BA (2013) Regenerative glutamate release by presynaptic NMDA receptors contributes to spreading depression. J Cereb Blood Flow Metab 33:1582-94 [Journal] [PubMed]

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