Citation Relationships



Eyal G, Verhoog MB, Testa-Silva G, Deitcher Y, Benavides-Piccione R, DeFelipe J, de Kock CP, Mansvelder HD, Segev I (2018) Human Cortical Pyramidal Neurons: From Spines to Spikes via Models Front Cell Neurosci 12:181 [PubMed]

   Comprehensive models of human cortical pyramidal neurons (Eyal et al 2018)

References and models cited by this paper

References and models that cite this paper

Alonso-Nanclares L, Gonzalez-Soriano J, Rodriguez JR, DeFelipe J (2008) Gender differences in human cortical synaptic density. Proc Natl Acad Sci U S A 105:14615-9 [Journal] [PubMed]

Amunts K, Ebell C, Muller J, Telefont M, Knoll A, Lippert T (2016) The Human Brain Project: Creating a European Research Infrastructure to Decode the Human Brain. Neuron 92:574-581 [Journal] [PubMed]

Angelino E, Brenner MP (2007) Excitability Constraints on Voltage-Gated Sodium Channels. PLoS Comput Biol 3:e177 [Journal] [PubMed]

Araya R, Vogels TP, Yuste R (2014) Activity-dependent dendritic spine neck changes are correlated with synaptic strength. Proc Natl Acad Sci U S A : [PubMed]

Arellano JI, Espinosa A, Fairén A, Yuste R, DeFelipe J (2007) Non-synaptic dendritic spines in neocortex. Neuroscience 145:464-9 [Journal] [PubMed]

Avoli M, Louvel J, Pumain R, Köhling R (2005) Cellular and molecular mechanisms of epilepsy in the human brain. Prog Neurobiol 77:166-200 [Journal] [PubMed]

Ballesteros-Yáñez I, Benavides-Piccione R, Elston GN, Yuste R, DeFelipe J (2006) Density and morphology of dendritic spines in mouse neocortex. Neuroscience 138:403-9 [Journal] [PubMed]

Benavides-Piccione R, Arellano JI, DeFelipe J (2005) Catecholaminergic innervation of pyramidal neurons in the human temporal cortex. Cereb Cortex 15:1584-91 [Journal] [PubMed]

Benavides-Piccione R, Ballesteros-Yáñez I, DeFelipe J, Yuste R (2002) Cortical area and species differences in dendritic spine morphology. J Neurocytol 31:337-46 [PubMed]

Benavides-Piccione R, Fernaud-Espinosa I, Robles V, Yuste R, DeFelipe J (2013) Age-based comparison of human dendritic spine structure using complete three-dimensional reconstructions. Cereb Cortex 23:1798-810 [Journal] [PubMed]

Blazquez-Llorca L, Merchán-Pérez Á, Rodríguez JR, Gascón J, DeFelipe J (2013) FIB/SEM technology and Alzheimer's disease: three-dimensional analysis of human cortical synapses. J Alzheimers Dis 34:995-1013 [Journal] [PubMed]

Bono J, Wilmes KA, Clopath C (2017) Modelling plasticity in dendrites: from single cells to networks. Curr Opin Neurobiol 46:136-141 [Journal] [PubMed]

Brent R (1976) A new algorithm for minimizing a function of several variables without calculating derivatives. Algorithms For Minimization Without Derivatives :200-248

Carnevale NT, Hines ML (2006) The NEURON Book [Journal]

Cartailler J, Kwon T, Yuste R, Holcman D (2018) Deconvolution of Voltage Sensor Time Series and Electro-diffusion Modeling Reveal the Role of Spine Geometry in Controlling Synaptic Strength. Neuron 97:1126-1136.e10 [Journal] [PubMed]

DeFelipe J (2015) The anatomical problem posed by brain complexity and size: a potential solution. Front Neuroanat 9:104 [Journal] [PubMed]

DeFelipe J, Alonso-Nanclares L, Arellano JI (2002) Microstructure of the neocortex: comparative aspects. J Neurocytol 31:299-316 [PubMed]

DeFelipe J, Farinas I (1992) The pyramidal neuron of the cerebral cortex: morphological and chemical characteristics of the synaptic inputs. Prog Neurobiol 39:563-607 [PubMed]

Deitcher Y, Eyal G, Kanari L, Verhoog MB, Atenekeng Kahou GA, Mansvelder HD, de Kock CPJ, Segev I (2017) Comprehensive Morpho-Electrotonic Analysis Shows 2 Distinct Classes of L2 and L3 Pyramidal Neurons in Human Temporal Cortex. Cereb Cortex 27:5398-5414 [Journal] [PubMed]

   2 Distinct Classes of L2 and L3 Pyramidal Neurons in Human Temporal Cortex (Deitcher et al 2017) [Model]

Del Río MR, DeFelipe J (1994) A study of SMI 32-stained pyramidal cells, parvalbumin-immunoreactive chandelier cells, and presumptive thalamocortical axons in the human temporal neocortex. J Comp Neurol 342:389-408 [Journal] [PubMed]

Destexhe A, Rudolph M, Pare D (2003) The high-conductance state of neocortical neurons in vivo. Nat Rev Neurosci 4:739-51 [PubMed]

Doron M, Chindemi G, Muller E, Markram H, Segev I (2017) Timed Synaptic Inhibition Shapes NMDA Spikes, Influencing Local Dendritic Processing and Global I/O Properties of Cortical Neurons. Cell Rep 21:1550-1561 [Journal] [PubMed]

   Shaping NMDA spikes by timed synaptic inhibition on L5PC (Doron et al. 2017) [Model]

Druckmann S, Banitt Y, Gidon A, Schurmann F, Markram H, Segev I (2007) A novel multiple objective optimization framework for constraining conductance-based neuron models by experimental data. Front Neurosci 1:7-18 [PubMed]

Egger R, Dercksen VJ, Udvary D, Hege HC, Oberlaender M (2014) Generation of dense statistical connectomes from sparse morphological data. Front Neuroanat 8:129 [Journal] [PubMed]

Elston GN, Benavides-Piccione R, DeFelipe J (2001) The pyramidal cell in cognition: a comparative study in human and monkey. J Neurosci 21:RC163-31 [PubMed]

Eyal G, Mansvelder HD, de Kock CP, Segev I (2014) Dendrites impact the encoding capabilities of the axon. J Neurosci 34:8063-71 [Journal] [PubMed]

Eyal G, Verhoog MB, Testa-Silva G, Deitcher Y, Lodder JC, Benavides-Piccione R, Morales J, DeFelipe J, de Kock CP, Mansvelder HD, Segev I (2016) Unique membrane properties and enhanced signal processing in human neocortical neurons. Elife [Journal] [PubMed]

   Human L2/3 pyramidal cells with low Cm values (Eyal et al. 2016) [Model]

Farinella M, Ruedt DT, Gleeson P, Lanore F, Silver RA (2014) Glutamate-bound NMDARs arising from in vivo-like network activity extend spatio-temporal integration in a L5 cortical pyramidal cell model. PLoS Comput Biol 10:e1003590 [Journal] [PubMed]

Feldmeyer D, bke J, Silver RA, Sakmann B (2002) Synaptic connections between layer 4 spiny neurone-layer 2-3 pyramidal cell pairs in juvenile rat barrel cortex: physiology and anatomy of interlaminar signalling within a cortical column. J Physiol 538:803-22 [PubMed]

Feldmeyer D, Lubke J, Sakmann B (2006) Efficacy and connectivity of intracolumnar pairs of layer 2-3 pyramidal cells in the barrel cortex of juvenile rats. J Physiol 575:583-602 [PubMed]

Garey LJ (2006) Brodmann's ‘Localisation in the Cerebral Cortex

Harnett MT, Makara JK, Spruston N, Kath WL, Magee JC (2012) Synaptic amplification by dendritic spines enhances input cooperativity. Nature 491:599-602 [PubMed]

Hawrylycz M, Anastassiou C, Arkhipov A, Berg J, Buice M, Cain N, Gouwens NW, Gratiy S, Iyer R, Lee JH, Mihalas S, Mitelut C, Olsen S, Reid RC, Teeter C, de Vries S, Waters J, Zeng H, Koch C, MindScope (2016) Inferring cortical function in the mouse visual system through large-scale systems neuroscience. Proc Natl Acad Sci U S A 113:7337-44 [Journal] [PubMed]

Hay E, Hill S, Schurmann F, Markram H, Segev I (2011) Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties. PLoS Comput Biol 7:e1002107 [Journal] [PubMed]

   Cortical Layer 5b pyr. cell with [Na+]i mechanisms, from Hay et al 2011 (Zylbertal et al 2017) [Model]
   L5b PC model constrained for BAC firing and perisomatic current step firing (Hay et al., 2011) [Model]
   Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2017) [Model]

Hay E, Schurmann F, Markram H, Segev I (2013) Preserving Axo-somatic Spiking Features Despite Diverse Dendritic Morphology. J Neurophysiol 109(12):2972-81 [Journal] [PubMed]

   Preserving axosomatic spiking features despite diverse dendritic morphology (Hay et al., 2013) [Model]

Hay E, Segev I (2015) Dendritic excitability and gain control in recurrent cortical microcircuits Cerebral Cortex 25(10):3561-3571 [Journal] [PubMed]

   Microcircuits of L5 thick tufted pyramidal cells (Hay & Segev 2015) [Model]
   Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2017) [Model]

Herz AV, Gollisch T, Machens CK, Jaeger D (2006) Modeling single-neuron dynamics and computations: a balance of detail and abstraction. Science 314:80-5 [PubMed]

Jadi MP, Behabadi BF, Poleg-Polsky A, Schiller J, Mel BW (2014) An Augmented Two-Layer Model Captures Nonlinear Analog Spatial Integration Effects in Pyramidal Neuron Dendrites. Proc IEEE Inst Electr Electron Eng [Journal] [PubMed]

Jahr CE, Stevens CF (1990) Voltage dependence of NMDA-activated macroscopic conductances predicted by single-channel kinetics. J Neurosci 10:3178-82 [PubMed]

Kasthuri N, Hayworth KJ, Berger DR, Schalek RL, Conchello JA, Knowles-Barley S, Lee D, Vázque (2015) Saturated Reconstruction of a Volume of Neocortex. Cell 162:648-61 [Journal] [PubMed]

Koch C, Jones A (2016) Big Science, Team Science, and Open Science for Neuroscience. Neuron 92:612-616 [Journal] [PubMed]

Koch C, Poggio T, Torre V (1982) Retinal ganglion cells: a functional interpretation of dendritic morphology. Philos Trans R Soc Lond B Biol Sci 298:227-63 [PubMed]

Koch C, Segev I (2000) The role of single neurons in information processing. Nat Neurosci 3 Suppl:1171-7 [PubMed]

Köhling R, Avoli M (2006) Methodological approaches to exploring epileptic disorders in the human brain in vitro. J Neurosci Methods 155:1-19 [Journal] [PubMed]

Kole MH, Stuart GJ (2012) Signal processing in the axon initial segment. Neuron 73:235-47 [PubMed]

Kwon T, Sakamoto M, Peterka DS, Yuste R (2017) Attenuation of Synaptic Potentials in Dendritic Spines. Cell Rep 20:1100-1110 [Journal] [PubMed]

Larkum ME, Nevian T, Sandler M, Polsky A, Schiller J (2009) Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: a new unifying principle. Science 325:756-60 [Journal] [PubMed]

   Synaptic integration in tuft dendrites of layer 5 pyramidal neurons (Larkum et al. 2009) [Model]

Larkum ME, Zhu JJ, Sakmann B (1999) A new cellular mechanism for coupling inputs arriving at different cortical layers. Nature 398:338-41 [PubMed]

Lavzin M, Rapoport S, Polsky A, Garion L, Schiller J (2012) Nonlinear dendritic processing determines angular tuning of barrel cortex neurons in vivo. Nature 490:397-401 [Journal] [PubMed]

   Nonlinear dendritic processing in barrel cortex spiny stellate neurons (Lavzin et al. 2012) [Model]

Lein E, Borm LE, Linnarsson S (2017) The promise of spatial transcriptomics for neuroscience in the era of molecular cell typing. Science 358:64-69 [Journal] [PubMed]

Magee JC, Cook EP (2000) Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons. Nat Neurosci 3:895-903 [PubMed]

   CA1 pyramidal neuron: Synaptic Scaling (Magee, Cook 2000) [Model]

Major G, Larkum ME, Schiller J (2013) Active Properties of Neocortical Pyramidal Neuron Dendrites. Annu Rev Neurosci 36:1-24 [PubMed]

Markram H, Lubke J, Frotscher M, Roth A, Sakmann B (1997) Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex. J Physiol 500 ( Pt 2):409-40 [PubMed]

Markram H, Lubke J, Frotscher M, Sakmann B (1997) Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs. Science 275:213-5 [PubMed]

Markram H, Muller E, Ramaswamy S, Reimann MW, Abdellah M, Sanchez CA, Ailamaki A, Alonso-Nanclares L, Antille N, Arsever S, Kahou GA, Berger TK, Bilgili A, Buncic N, Chalimourda A, Chindemi G, Courcol JD, Delalondre F, Delattre V, Druckmann S, Dumusc R, Dynes J, Eilemann S, Gal E, Gevaert ME, Ghobril JP, Gidon A, Graham JW, Gupta A, Haenel V, Hay E, Heinis T, Hernando JB, Hines M, Kanari L, Keller D, Kenyon J, Khazen G, Kim Y, King JG, Kisvarday Z, Kumbhar P, Lasserre S, Le Be JV, Magalhães BR, Merchan-Perez A, Meystre J, Morrice BR, Muller J, Muñoz-Cespedes A, et al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry. Cell 163:456-92 [Journal] [PubMed]

   The neocortical microcircuit collaboration portal (Markram et al. 2015) [Model]

Martin CL, Chun M (2016) The BRAIN Initiative: Building, Strengthening, and Sustaining. Neuron 92:570-573 [Journal] [PubMed]

McCulloch WS, Pitts W (1990) A logical calculus of the ideas immanent in nervous activity. 1943. Bull Math Biol 52:99-115; discussion 73-97 [PubMed]

Mel BW (1992) NMDA-based pattern discrimination in a modeled cortical neuron. Neural Comput 4:502-517

Mel BW, Schiller J, Poirazi P (2017) Synaptic plasticity in dendrites: complications and coping strategies. Curr Opin Neurobiol 43:177-186 [Journal] [PubMed]

Mohan H, Verhoog MB, Doreswamy KK, Eyal G, Aardse R, Lodder BN, Goriounova NA, Asamoah B, B B (2015) Dendritic and Axonal Architecture of Individual Pyramidal Neurons across Layers of Adult Human Neocortex. Cereb Cortex 25:4839-53 [Journal] [PubMed]

Molnár G, Rózsa M, Baka J, Holderith N, Barzó P, Nusser Z, Tamás G (2016) Human pyramidal to interneuron synapses are mediated by multi-vesicular release and multiple docked vesicles. Elife [Journal] [PubMed]

Palmer LM, Shai AS, Reeve JE, Anderson HL, Paulsen O, Larkum ME (2014) NMDA spikes enhance action potential generation during sensory input. Nat Neurosci [Journal] [PubMed]

Palmer LM, Stuart GJ (2009) Membrane potential changes in dendritic spines during action potentials and synaptic input. J Neurosci 29:6897-903 [Journal] [PubMed]

   Membrane potential changes in dendritic spines during APs and synaptic input (Palmer & Stuart 2009) [Model]

Poirazi P, Brannon T, Mel BW (2003a) Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron 37:977-987 [Journal] [PubMed]

   CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003) [Model]

Poirazi P, Brannon T, Mel BW (2003b) Pyramidal Neuron as Two-Layer Neural Network. Neuron 37:989-999 [Journal] [PubMed]

   CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003) [Model]

Poirazi P, Mel BW (2001) Impact of active dendrites and structural plasticity on the memory capacity of neural tissue. Neuron 29:779-96 [PubMed]

Polsky A, Mel BW, Schiller J (2004) Computational subunits in thin dendrites of pyramidal cells. Nat Neurosci 7:621-7 [Journal] [PubMed]

   CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003) [Model]

Poo MM, Du JL, Ip NY, Xiong ZQ, Xu B, Tan T (2016) China Brain Project: Basic Neuroscience, Brain Diseases, and Brain-Inspired Computing. Neuron 92:591-596 [Journal] [PubMed]

Popovic MA, Carnevale N, Rozsa B, Zecevic D (2015) Electrical behaviour of dendritic spines as revealed by voltage imaging. Nat Commun 6:8436 [Journal] [PubMed]

RALL W (1959) Branching dendritic trees and motoneuron membrane resistivity. Exp Neurol 1:491-527 [PubMed]

Rall W (1964) Theoretical significance of dendritic trees for neuronal input output relations Neural Theory and Modeling, Reiss RF, ed. pp.73 [Journal]

   Effects of synaptic location and timing on synaptic integration (Rall 1964) [Model]

Rall W (1967) Distinguishing theoretical synaptic potentials computed for different soma-dendritic distributions of synaptic input. J Neurophysiol 30:1138-68 [Journal] [PubMed]

Rall W (1969) Time constants and electrotonic length of membrane cylinders and neurons. Biophys J 9:1483-508 [PubMed]

Rall W, Burke RE, Smith TG, Nelson PG, Frank K (1967) Dendritic location of synapses and possible mechanisms for the monosynaptic EPSP in motoneurons. J Neurophysiol 30:1169-93 [Journal] [PubMed]

Ranjan R, Khazen G, Gambazzi L, Ramaswamy S, Hill SL, Schürmann F, Markram H (2011) Channelpedia: an integrative and interactive database for ion channels. Front Neuroinform 5:36 [Journal] [PubMed]

Rapp M, Yarom Y, Segev I (1992) The impact of parallel fiber background activity on the cable properties of cerebellar Purkinje cells Neural Comput 4:518-533

Rhodes P (2006) The properties and implications of NMDA spikes in neocortical pyramidal cells. J Neurosci 26:6704-15 [PubMed]

Sarid L, Bruno R, Sakmann B, Segev I, Feldmeyer D (2007) Modeling a layer 4-to-layer 2-3 module of a single column in rat neocortex: interweaving in vitro and in vivo experimental observations. Proc Natl Acad Sci U S A 104:16353-8 [PubMed]

Sarid L, Feldmeyer D, Gidon A, Sakmann B, Segev I (2015) Contribution of intracolumnar layer 2/3-to-layer 2/3 excitatory connections in shaping the response to whisker deflection in rat barrel cortex. Cereb Cortex 25:849-58 [Journal] [PubMed]

Schiller J, Major G, Koester HJ, Schiller Y (2000) NMDA spikes in basal dendrites of cortical pyramidal neurons. Nature 404:285-9 [PubMed]

Schmidt-Hieber C, Toleikyte G, Aitchison L, Roth A, Clark BA, Branco T, Häusser M (2017) Active dendritic integration as a mechanism for robust and precise grid cell firing. Nat Neurosci 20:1114-1121 [Journal] [PubMed]

   Active dendritic integration in robust and precise grid cell firing (Schmidt-Hieber et al 2017) [Model]

Segev I, Friedman A, White EL, Gutnick MJ (1995) Electrical consequences of spine dimensions in a model of a cortical spiny stellate cell completely reconstructed from serial thin sections. J Comput Neurosci 2:117-30 [Journal] [PubMed]

Shalev-Shwartz S,Ben-David S (2014) Understanding Machine Learning: From Theory to Algorithms

Shen GY, Chen WR, Midtgaard J, Shepherd GM, Hines ML (1999) Computational analysis of action potential initiation in mitral cell soma and dendrites based on dual patch recordings. J Neurophysiol 82:3006-20 [Journal] [PubMed]

   Action potential initiation in the olfactory mitral cell (Shen et al 1999) [Model]

Shimizu E, Tang YP, Rampon C, Tsien JZ (2000) NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation. Science 290:1170-4 [PubMed]

Siraisi NG (2007) David Gentilcore, Medical charlatanism in early modern Italy, Oxford: Oxford University Press, 2006. Pp. 448. Pounds 65.00. ISBN 0199245355. Soc Hist Med 20:393-4 [PubMed]

Smith SL, Smith IT, Branco T, Hausser M (2013) Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo. Nature 503:115-20 [Journal] [PubMed]

   Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo (Smith et al 2013) [Model]

Spruston N (2008) Pyramidal neurons: dendritic structure and synaptic integration. Nat Rev Neurosci 9:206-21 [PubMed]

Stuart GJ, Sakmann B (1994) Active propagation of somatic action potentials into neocortical pyramidal cell dendrites. Nature 367:69-72 [PubMed]

Svoboda K, Tank DW, Denk W (1996) Direct measurement of coupling between dendritic spines and shafts. Science 272:716-9 [PubMed]

Szabadics J, Varga C, Molnar G, Olah S, Barzó P, Tamas G (2006) Excitatory effect of GABAergic axo-axonic cells in cortical microcircuits. Science 311:233-5 [PubMed]

Takahashi N, Oertner TG, Hegemann P, Larkum ME (2016) Active cortical dendrites modulate perception. Science 354:1587-1590 [Journal] [PubMed]

Testa-Silva G, Verhoog MB, Goriounova NA, Loebel A, Hjorth J, Baayen JC, de Kock CP, Mansveld (2010) Human synapses show a wide temporal window for spike-timing-dependent plasticity. Front Synaptic Neurosci 2:12 [PubMed]

Testa-Silva G, Verhoog MB, Linaro D, de Kock CP, Baayen JC, Meredith RM, De Zeeuw CI, Giuglia (2014) High bandwidth synaptic communication and frequency tracking in human neocortex. PLoS Biol 12:e1002007 [Journal] [PubMed]

Tian C, Wang K, Ke W, Guo H, Shu Y (2014) Molecular identity of axonal sodium channels in human cortical pyramidal cells. Front Cell Neurosci 8:297 [Journal] [PubMed]

Tønnesen J, Katona G, Rózsa B, Nägerl UV (2014) Spine neck plasticity regulates compartmentalization of synapses. Nat Neurosci 17:678-85 [Journal] [PubMed]

Varga C, Tamas G, Barzo P, Olah S, Somogyi P (2015) Molecular and Electrophysiological Characterization of GABAergic Interneurons Expressing the Transcription Factor COUP-TFII in the Adult Human Temporal Cortex. Cereb Cortex 25:4430-49 [Journal] [PubMed]

Verhoog MB, Goriounova NA, Obermayer J, Stroeder J, Hjorth JJ, Testa-Silva G, Baayen JC, de K (2013) Mechanisms underlying the rules for associative plasticity at adult human neocortical synapses. J Neurosci 33:17197-208 [Journal] [PubMed]

Wuarin JP, Peacock WJ, Dudek FE (1992) Single-electrode voltage-clamp analysis of the N-methyl-D-aspartate component of synaptic responses in neocortical slices from children with intractable epilepsy. J Neurophysiol 67:84-93 [Journal] [PubMed]

Aberra AS, Peterchev AV, Grill WM (2018) Biophysically realistic neuron models for simulation of cortical stimulation J. Neural Eng. [Journal] [PubMed]

   Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018) [Model]

(100 refs)