Citation Relationships



Greenstein JL, Wu R, Po S, Tomaselli GF, Winslow RL (2000) Role of the calcium-independent transient outward current I(to1) in shaping action potential morphology and duration. Circ Res 87:1026-33 [PubMed]

   Kv4.3, Kv1.4 encoded K(+) channel in heart cells (Greenstein et al 2000) (XPP)

   Kv4.3, Kv1.4 encoded K channel in heart cells & tachy. (Winslow et al 1999, Greenstein et al 2000)

References and models cited by this paper

References and models that cite this paper

An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (2000) Modulation of A-type potassium channels by a family of calcium sensors. Nature 403:553-6 [Journal] [PubMed]

Barry DM, Xu H, Schuessler RB, Nerbonne JM (1998) Functional knockout of the transient outward current, long-QT syndrome, and cardiac remodeling in mice expressing a dominant-negative Kv4 alpha subunit. Circ Res 83:560-7 [PubMed]

Beuckelmann DJ, Näbauer M, Erdmann E (1993) Alterations of K+ currents in isolated human ventricular myocytes from patients with terminal heart failure. Circ Res 73:379-85 [PubMed]

Brahmajothi MV, Campbell DL, Rasmusson RL, Morales MJ, Trimmer JS, Nerbonne JM, Strauss HC (1999) Distinct transient outward potassium current (Ito) phenotypes and distribution of fast-inactivating potassium channel alpha subunits in ferret left ventricular myocytes. J Gen Physiol 113:581-600 [PubMed]

Dilks D, Ling HP, Cockett M, Sokol P, Numann R (1999) Cloning and expression of the human kv4.3 potassium channel. J Neurophysiol 81:1974-7 [Journal] [PubMed]

Dixon JE, Shi W, Wang HS, McDonald C, Yu H, Wymore RS, Cohen IS, McKinnon D (1996) Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current. Circ Res 79:659-68 [PubMed]

Dumaine R, Towbin JA, Brugada P, Vatta M, Nesterenko DV, Nesterenko VV, Brugada J, Brugada R, Antzelevitch C (1999) Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependent. Circ Res 85:803-9 [PubMed]

Faivre JF, Calmels TP, Rouanet S, Javré JL, Cheval B, Bril A (1999) Characterisation of Kv4.3 in HEK293 cells: comparison with the rat ventricular transient outward potassium current. Cardiovasc Res 41:188-99 [PubMed]

Flesch M, Schwinger RH, Schiffer F, Frank K, Südkamp M, Kuhn-Regnier F, Arnold G, Böhm M (1996) Evidence for functional relevance of an enhanced expression of the Na(+)-Ca2+ exchanger in failing human myocardium. Circulation 94:992-1002 [PubMed]

Guo W, Li H, London B, Nerbonne JM (2000) Functional consequences of elimination of i(to,f) and i(to,s): early afterdepolarizations, atrioventricular block, and ventricular arrhythmias in mice lacking Kv1.4 and expressing a dominant-negative Kv4 alpha subunit. Circ Res 87:73-9 [PubMed]

Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391:85-100 [PubMed]

Hoppe UC, Johns DC, Marbán E, O'Rourke B (1999) Manipulation of cellular excitability by cell fusion: effects of rapid introduction of transient outward K+ current on the guinea pig action potential. Circ Res 84:964-72 [PubMed]

Jafri MS, Rice JJ, Winslow RL (1998) Cardiac Ca2+ dynamics: the roles of ryanodine receptor adaptation and sarcoplasmic reticulum load. Biophys J 74:1149-68 [Journal] [PubMed]

Kääb S, Dixon J, Duc J, Ashen D, Näbauer M, Beuckelmann DJ, Steinbeck G, McKinnon D, Tomaselli GF (1998) Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density. Circulation 98:1383-93 [PubMed]

Kääb S, Nuss HB, Chiamvimonvat N, O'Rourke B, Pak PH, Kass DA, Marban E, Tomaselli GF (1996) Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circ Res 78:262-73 [PubMed]

Kong W, Po S, Yamagishi T, Ashen MD, Stetten G, Tomaselli GF (1998) Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing. Am J Physiol 275:H1963-70 [Journal] [PubMed]

Li GR, Feng J, Yue L, Carrier M (1998) Transmural heterogeneity of action potentials and Ito1 in myocytes isolated from the human right ventricle. Am J Physiol 275:H369-77 [Journal] [PubMed]

Litovsky SH, Antzelevitch C (1989) Rate dependence of action potential duration and refractoriness in canine ventricular endocardium differs from that of epicardium: role of the transient outward current. J Am Coll Cardiol 14:1053-66 [PubMed]

Liu DW, Gintant GA, Antzelevitch C (1993) Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle. Circ Res 72:671-87 [PubMed]

Lukas A, Antzelevitch C (1993) Differences in the electrophysiological response of canine ventricular epicardium and endocardium to ischemia. Role of the transient outward current. Circulation 88:2903-15 [PubMed]

Luo CH, Rudy Y (1994) A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circ Res 74:1071-96 [PubMed]

   Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Meyer M, Schillinger W, Pieske B, Holubarsch C, Heilmann C, Posival H, Kuwajima G, Mikoshiba (1995) Alterations of sarcoplasmic reticulum proteins in failing human dilated cardiomyopathy. Circulation 92:778-84

Näbauer M, Beuckelmann DJ, Erdmann E (1993) Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure. Circ Res 73:386-94 [PubMed]

Näbauer M, Beuckelmann DJ, Uberfuhr P, Steinbeck G (1996) Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation 93:168-77 [PubMed]

Po S, Roberds S, Snyders DJ, Tamkun MM, Bennett PB (1993) Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current? Circ Res 72:1326-36 [PubMed]

Po S, Snyders DJ, Baker R, Tamkun MM, Bennett PB (1992) Functional expression of an inactivating potassium channel cloned from human heart. Circ Res 71:732-6 [PubMed]

Stengl M, Carmeliet E, Mubagwa K, Flameng W (1998) Modulation of transient outward current by extracellular protons and Cd2+ in rat and human ventricular myocytes. J Physiol 511 ( Pt 3):827-36 [PubMed]

Studer R, Reinecke H, Bilger J, Eschenhagen T, Böhm M, Hasenfuss G, Just H, Holtz J, Drexler H (1994) Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure. Circ Res 75:443-53 [PubMed]

Wettwer E, Amos GJ, Posival H, Ravens U (1994) Transient outward current in human ventricular myocytes of subepicardial and subendocardial origin. Circ Res 75:473-82 [PubMed]

Wickenden AD, Jegla TJ, Kaprielian R, Backx PH (1999) Regional contributions of Kv1.4, Kv4.2, and Kv4.3 to transient outward K+ current in rat ventricle. Am J Physiol 276:H1599-607 [Journal] [PubMed]

Winslow RL, Rice J, Jafri S, Marbán E, O'Rourke B (1999) Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies. Circ Res 84:571-86 [PubMed]

   Kv4.3, Kv1.4 encoded K channel in heart cells & tachy. (Winslow et al 1999, Greenstein et al 2000) [Model]

Yu H, Gao J, Wang H, Wymore R, Steinberg S, McKinnon D, Rosen MR, Cohen IS (2000) Effects of the renin-angiotensin system on the current I(to) in epicardial and endocardial ventricular myocytes from the canine heart. Circ Res 86:1062-8

Zagotta WN, Aldrich RW (1990) Voltage-dependent gating of Shaker A-type potassium channels in Drosophila muscle. J Gen Physiol 95:29-60 [PubMed]

Zygmunt AC, Robitelle DC, Eddlestone GT (1997) Ito1 dictates behavior of ICl(Ca) during early repolarization of canine ventricle. Am J Physiol 273:H1096-106 [Journal] [PubMed]

Clancy CE, Rudy Y (2002) Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation 105:1208-13 [PubMed]

   Markovian model for cardiac sodium channel (Clancy, Rudy 2002) [Model]

Flaim SN, Giles WR, McCulloch AD (2006) Contributions of sustained INa and IKv43 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytes. Am J Physiol Heart Circ Physiol 291:H2617-29 [Journal] [PubMed]

   INa and IKv4.3 heterogeneity in canine LV myocytes (Flaim et al 2006) [Model]

Greenstein JL, Hinch R, Winslow RL (2006) Mechanisms of excitation-contraction coupling in an integrative model of the cardiac ventricular myocyte. Biophys J 90:77-91 [Journal] [PubMed]

   Excitation-contraction coupling in an integrative heart cell model (Greenstein et al 2006) [Model]

Greenstein JL, Tanskanen AJ, Winslow RL (2004) Modeling the actions of beta-adrenergic signaling on excitation--contraction coupling processes. Ann N Y Acad Sci 1015:16-27 [Journal] [PubMed]

Greenstein JL, Winslow RL (2002) An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release. Biophys J 83:2918-45 [Journal] [PubMed]

Hund TJ, Rudy Y (2004) Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model. Circulation 110:3168-74 [Journal] [PubMed]

   A dynamic model of the canine ventricular myocyte (Hund, Rudy 2004) [Model]

Iyer V, Mazhari R, Winslow RL (2004) A computational model of the human left-ventricular epicardial myocyte. Biophys J 87:1507-25 [Journal] [PubMed]

Liu YC, Wang YJ, Wu SN (2008) The mechanisms of propofol-induced block on ion currents in differentiated H9c2 cardiac cells. Eur J Pharmacol 590:93-8 [Journal] [PubMed]

   Efffect of propofol on potassium current in cardiac H9c2 cells (Liu et al. 2008) [Model]

Mazhari R, Greenstein JL, Winslow RL, Marbán E, Nuss HB (2001) Molecular interactions between two long-QT syndrome gene products, HERG and KCNE2, rationalized by in vitro and in silico analysis. Circ Res 89:33-8 [PubMed]

Patel SP, Campbell DL (2005) Transient outward potassium current, 'Ito', phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms. J Physiol 569:7-39 [Journal] [PubMed]

Tanskanen AJ, Greenstein JL, O'Rourke B, Winslow RL (2005) The role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizations. Biophys J 88:85-95 [Journal] [PubMed]

Winslow RL, Cortassa S, Greenstein JL (2005) Using models of the myocyte for functional interpretation of cardiac proteomic data. J Physiol 563:73-81 [Journal] [PubMed]

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