Citation Relationships



Cortassa S, Aon MA, Marbán E, Winslow RL, O'Rourke B (2003) An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys J 84:2734-55 [PubMed]

   Excitation-contraction coupling/mitochondrial energetics (ECME) model (Cortassa et al. 2006)

References and models cited by this paper

References and models that cite this paper

Balaban RS (2002) Cardiac energy metabolism homeostasis: role of cytosolic calcium. J Mol Cell Cardiol 34:1259-71 [PubMed]

Bers DM (2001) Excitation-Contraction Coupling and Cardiac Contractile Force (2nd edn)

Bittl JA, Ingwall JS (1985) Reaction rates of creatine kinase and ATP synthesis in the isolated rat heart. A 31P NMR magnetization transfer study. J Biol Chem 260:3512-7 [PubMed]

Bose S, French S, Evans FJ, Joubert F, Balaban RS (2003) Metabolic network control of oxidative phosphorylation: multiple roles of inorganic phosphate. J Biol Chem 278:39155-65 [Journal] [PubMed]

Brandes R, Bers DM (1997) Intracellular Ca2+ increases the mitochondrial NADH concentration during elevated work in intact cardiac muscle. Circ Res 80:82-7 [PubMed]

Brandes R, Bers DM (1999) Analysis of the mechanisms of mitochondrial NADH regulation in cardiac trabeculae. Biophys J 77:1666-82 [Journal] [PubMed]

Brandes R, Bers DM (2002) Simultaneous measurements of mitochondrial NADH and Ca(2+) during increased work in intact rat heart trabeculae. Biophys J 83:587-604 [Journal] [PubMed]

Brown GC (1992) Control of respiration and ATP synthesis in mammalian mitochondria and cells. Biochem J 284 ( Pt 1):1-13 [PubMed]

CHANCE B, WILLIAMS GR (1955) A method for the localization of sites for oxidative phosphorylation. Nature 176:250-4 [PubMed]

Chen C, Ko Y, Delannoy M, Ludtke SJ, Chiu W, Pedersen PL (2004) Mitochondrial ATP synthasome: three-dimensional structure by electron microscopy of the ATP synthase in complex formation with carriers for Pi and ADP/ATP. J Biol Chem 279:31761-8 [Journal] [PubMed]

Clark JF, Kuznetsov AV, Radda GK (1997) ADP-regenerating enzyme systems in mitochondria of guinea pig myometrium and heart. Am J Physiol 272:C399-404 [Journal] [PubMed]

Cohen S, Hindmarsh A (1994) Cvode user guide Tech Rep

Ebus JP, Stienen GJ (1996) Origin of concurrent ATPase activities in skinned cardiac trabeculae from rat. J Physiol 492 ( Pt 3):675-87

Echarte MM, Levi V, Villamil AM, Rossi RC, Rossi JP (2001) Quantitation of plasma membrane calcium pump phosphorylated intermediates by electrophoresis. Anal Biochem 289:267-73 [Journal] [PubMed]

Eijgelshoven MH, van Beek JH, Mottet I, Nederhoff MG, van Echteld CJ, Westerhof N (1994) Cardiac high-energy phosphates adapt faster than oxygen consumption to changes in heart rate. Circ Res 75:751-9 [PubMed]

Elimban V, Zhao D, Dhalla NS (1987) A comparative study of the rat heart sarcolemmal Ca2+-dependent ATPase and myosin ATPase. Mol Cell Biochem 77:143-52 [PubMed]

Elliott AC, Smith GL, Allen DG (1994) The metabolic consequences of an increase in the frequency of stimulation in isolated ferret hearts. J Physiol 474:147-59 [PubMed]

Evans CL, Matsuoka Y (1915) The effect of various mechanical conditions on the gaseous metabolism and efficiency of the mammalian heart. J Physiol 49:378-405 [PubMed]

Gunter KK, Gunter TE (1994) Transport of calcium by mitochondria. J Bioenerg Biomembr 26:471-85

Gunter TE, Pfeiffer DR (1990) Mechanisms by which mitochondria transport calcium. Am J Physiol 258:C755-86 [Journal] [PubMed]

Harrison GJ, van Wijhe MH, de Groot B, Dijk FJ, Gustafson LA, van Beek JH (2003) Glycolytic buffering affects cardiac bioenergetic signaling and contractile reserve similar to creatine kinase. Am J Physiol Heart Circ Physiol 285:H883-90 [Journal] [PubMed]

Heineman FW, Balaban RS (1990) Control of mitochondrial respiration in the heart in vivo. Annu Rev Physiol 52:523-42 [Journal] [PubMed]

Hoerter JA, Ventura-Clapier R, Kuznetsov A (1994) Compartmentation of creatine kinases during perinatal development of mammalian heart. Mol Cell Biochem 133-134:277-86 [PubMed]

Hüser J, Blatter LA, Sheu SS (2000) Mitochondrial calcium in heart cells: beat-to-beat oscillations or slow integration of cytosolic transients? J Bioenerg Biomembr 32:27-33 [PubMed]

Ingwall JS, Weiss RG (2004) Is the failing heart energy starved? On using chemical energy to support cardiac function. Circ Res 95:135-45 [Journal] [PubMed]

Jacobus WE (1985) Respiratory control and the integration of heart high-energy phosphate metabolism by mitochondrial creatine kinase. Annu Rev Physiol 47:707-25 [Journal] [PubMed]

Jafri MS, Rice JJ, Winslow RL (1998) Cardiac Ca2+ dynamics: the roles of ryanodine receptor adaptation and sarcoplasmic reticulum load. Biophys J 74:1149-68 [Journal] [PubMed]

Janssen PM, Stull LB, Marbán E (2002) Myofilament properties comprise the rate-limiting step for cardiac relaxation at body temperature in the rat. Am J Physiol Heart Circ Physiol 282:H499-507 [Journal] [PubMed]

Jeneson JA, Westerhoff HV, Kushmerick MJ (2000) A metabolic control analysis of kinetic controls in ATP free energy metabolism in contracting skeletal muscle. Am J Physiol Cell Physiol 279:C813-32 [Journal] [PubMed]

Johnson EA (1979) Force-interval relationship in cardiac muscle Handbook of Physiology. The Cardiovascular System. The Heart :475-492

Joubert F, Gillet B, Mazet JL, Mateo P, Beloeil J, Hoerter JA (2000) Evidence for myocardial ATP compartmentation from NMR inversion transfer analysis of creatine kinase fluxes. Biophys J 79:1-13 [PubMed]

Joubert F, Mateo P, Gillet B, Beloeil JC, Mazet JL, Hoerter JA (2004) CK flux or direct ATP transfer: versatility of energy transfer pathways evidenced by NMR in the perfused heart. Mol Cell Biochem 256-257:43-58 [PubMed]

Kaasik A, Veksler V, Boehm E, Novotova M, Minajeva A, Ventura-Clapier R (2001) Energetic crosstalk between organelles: architectural integration of energy production and utilization. Circ Res 89:153-9 [PubMed]

Kadenbach B (2003) Intrinsic and extrinsic uncoupling of oxidative phosphorylation. Biochim Biophys Acta 1604:77-94 [PubMed]

Karatzaferi C, Myburgh KH, Chinn MK, Franks-Skiba K, Cooke R (2003) Effect of an ADP analog on isometric force and ATPase activity of active muscle fibers. Am J Physiol Cell Physiol 284:C816-25 [Journal] [PubMed]

Korzeniewski B, Mazat JP (1996) Theoretical studies on the control of oxidative phosphorylation in muscle mitochondria: application to mitochondrial deficiencies. Biochem J 319 ( Pt 1):143-8

Luo CH, Rudy Y (1994) A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circ Res 74:1071-96 [PubMed]

   Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Maack C, Cortassa S, Aon MA, Ganesan AN, Liu T, O'Rourke B (2006) Elevated cytosolic Na+ decreases mitochondrial Ca2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes. Circ Res 99:172-82 [Journal] [PubMed]

Magnus G, Keizer J (1998) Model of beta-cell mitochondrial calcium handling and electrical activity. I. Cytoplasmic variables. Am J Physiol 274:C1158-73 [PubMed]

Maier LS, Bers DM, Pieske B (2000) Differences in Ca(2+)-handling and sarcoplasmic reticulum Ca(2+)-content in isolated rat and rabbit myocardium. J Mol Cell Cardiol 32:2249-58 [Journal] [PubMed]

Matsuoka S, Sarai N, Jo H, Noma A (2004) Simulation of ATP metabolism in cardiac excitation-contraction coupling. Prog Biophys Mol Biol 85:279-99 [Journal] [PubMed]

Mulieri LA, Hasenfuss G, Ittleman F, Blanchard EM, Alpert NR (1989) Protection of human left ventricular myocardium from cutting injury with 2,3-butanedione monoxime. Circ Res 65:1441-9 [PubMed]

Nakao M, Gadsby DC (1989) [Na] and [K] dependence of the Na/K pump current-voltage relationship in guinea pig ventricular myocytes. J Gen Physiol 94:539-65 [PubMed]

Neely JR, Liebermeister H, Battersby EJ, Morgan HE (1967) Effect of pressure development on oxygen consumption by isolated rat heart. Am J Physiol 212:804-14

Neely JR, Whitmer M, Mochizuki S (1976) Effects of mechanical activity and hormones on myocardial glucose and fatty acid utilization. Circ Res 38:I22-30 [PubMed]

Page E (1978) Quantitative ultrastructural analysis in cardiac membrane physiology. Am J Physiol 235:C147-58 [Journal] [PubMed]

Pasa TC, Otero AS, Barrabin H, Scofano HM (1992) Regulation of the nucleotide dependence of the cardiac sarcolemma Ca(2+)-ATPase. J Mol Cell Cardiol 24:233-42 [PubMed]

Pate E, Cooke R (1989) A model of crossbridge action: the effects of ATP, ADP and Pi. J Muscle Res Cell Motil 10:181-96 [PubMed]

Pozzan T, Rizzuto R (2000) The renaissance of mitochondrial calcium transport. Eur J Biochem 267:5269-73 [PubMed]

Randle PJ (1979) Carbohydrate and fatty acid metabolism Handbook of Physiology, Berne RM:Sperelakis N:Geiger R, ed. pp.805

Regnier M, Martyn DA, Chase PB (1998) Calcium regulation of tension redevelopment kinetics with 2-deoxy-ATP or low [ATP] in rabbit skeletal muscle. Biophys J 74:2005-15

Rice JJ, Jafri MS, Winslow RL (2000) Modeling short-term interval-force relations in cardiac muscle. Am J Physiol Heart Circ Physiol 278:H913-31 [Journal] [PubMed]

Ruf T, Hebisch S, Gross R, Alpert N, Just H, Holubarsch C (1996) Modulation of myocardial economy and efficiency in mammalian failing and non-failing myocardium by calcium channel activation and beta-adrenergic stimulation. Cardiovasc Res 32:1047-55 [PubMed]

Rutter GA, Denton RM (1988) Regulation of NAD+-linked isocitrate dehydrogenase and 2-oxoglutarate dehydrogenase by Ca2+ ions within toluene-permeabilized rat heart mitochondria. Interactions with regulation by adenine nucleotides and NADH/NAD+ ratios. Biochem J 252:181-9 [PubMed]

Sakamoto J, Tonomura Y (1980) Order of release of ADP and Pi from phosphoenzyme with bound ADP of Ca2+-dependent ATPase from sarcoplasmic reticulum and of Na+, K+-dependent ATPase studied by ADP-inhibition patterns. J Biochem 87:1721-7 [PubMed]

Saks VA, Kaambre T, Sikk P, Eimre M, Orlova E, Paju K, Piirsoo A, Appaix F, Kay L, Regitz-Zagrosek V, Fleck E, Seppet E (2001) Intracellular energetic units in red muscle cells. Biochem J 356:643-57 [PubMed]

Saks VA, Kuznetsov AV, Vendelin M, Guerrero K, Kay L, Seppet EK (2006) Functional coupling as a basic mechanism of feedback regulation of cardiac energy metabolism. Mol Cell Biochem 256-257:185-99

Saks VA, Ventura-Clapier R, Aliev MK (1996) Metabolic control and metabolic capacity: two aspects of creatine kinase functioning in the cells. Biochim Biophys Acta 1274:81-8 [PubMed]

Saupe KW, Spindler M, Hopkins JC, Shen W, Ingwall JS (2000) Kinetic, thermodynamic, and developmental consequences of deleting creatine kinase isoenzymes from the heart. Reaction kinetics of the creatine kinase isoenzymes in the intact heart. J Biol Chem 275:19742-6 [Journal] [PubMed]

Selivanov VA, Alekseev AE, Hodgson DM, Dzeja PP, Terzic A (2004) Nucleotide-gated KATP channels integrated with creatine and adenylate kinases: amplification, tuning and sensing of energetic signals in the compartmentalized cellular environment. Mol Cell Biochem 256-257:243-56 [PubMed]

Shannon TR, Ginsburg KS, Bers DM (2000) Reverse mode of the sarcoplasmic reticulum calcium pump and load-dependent cytosolic calcium decline in voltage-clamped cardiac ventricular myocytes. Biophys J 78:322-33 [Journal] [PubMed]

Sheu SS (1989) Cytosolic sodium concentration regulates contractility of cardiac muscle. Basic Res Cardiol 84 Suppl 1:35-45 [PubMed]

Sheu SS, Fozzard HA (1982) Transmembrane Na+ and Ca2+ electrochemical gradients in cardiac muscle and their relationship to force development. J Gen Physiol 80:325-51 [PubMed]

Szigligeti P, Pankucsi C, Bányász T, Varró A, Nánási PP (1996) Action potential duration and force-frequency relationship in isolated rabbit, guinea pig and rat cardiac muscle. J Comp Physiol B 166:150-5 [PubMed]

Territo PR, French SA, Dunleavy MC, Evans FJ, Balaban RS (2001) Calcium activation of heart mitochondrial oxidative phosphorylation: rapid kinetics of mVO2, NADH, AND light scattering. J Biol Chem 276:2586-99 [Journal] [PubMed]

Vendelin M, Kongas O, Saks V (2000) Regulation of mitochondrial respiration in heart cells analyzed by reaction-diffusion model of energy transfer. Am J Physiol Cell Physiol 278:C747-64 [Journal] [PubMed]

Vendelin M, Lemba M, Saks VA (2004) Analysis of functional coupling: mitochondrial creatine kinase and adenine nucleotide translocase. Biophys J 87:696-713 [Journal] [PubMed]

Wier WG, Yue DT (1986) Intracellular calcium transients underlying the short-term force-interval relationship in ferret ventricular myocardium. J Physiol 376:507-30 [PubMed]

Williamson JR, Ford C, Illingworth J, Safer B (1976) Coordination of citric acid cycle activity with electron transport flux. Circ Res 38:I39-51 [PubMed]

Winslow RL, Rice J, Jafri S, Marbán E, O'Rourke B (1999) Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies. Circ Res 84:571-86 [PubMed]

   Kv4.3, Kv1.4 encoded K channel in heart cells & tachy. (Winslow et al 1999, Greenstein et al 2000) [Model]

Makadia HK, Anderson WD, Fey D, Sauter T, Schwaber JS, Vadigepalli R (2015) Multiscale model of dynamic neuromodulation integrating neuropeptide-induced signaling pathway activity with membrane electrophysiology. Biophys J 108:211-23 [Journal] [PubMed]

   Model of AngII signaling and membrane electrophysiology (Makadia, Anderson, Fey et al., 2015) [Model]

Winslow RL, Cortassa S, Greenstein JL (2005) Using models of the myocyte for functional interpretation of cardiac proteomic data. J Physiol 563:73-81 [Journal] [PubMed]

Winslow RL, Greenstein JL (2004) The ongoing journey to understand heart function through integrative modeling. Circ Res 95:1135-6 [Journal] [PubMed]

(73 refs)