Citation Relationships



Puglisi JL, Bers DM (2001) LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport. Am J Physiol Cell Physiol 281:C2049-60 [PubMed]

   A cardiac cell simulator (Puglisi and Bers 2001), applied to the QT interval (Busjahn et al 2004)

References and models cited by this paper

References and models that cite this paper

Beeler GW, Reuter H (1977) Reconstruction of the action potential of ventricular myocardial fibres. J Physiol 268:177-210 [Journal] [PubMed]

   Mammalian Ventricular Cell (Beeler and Reuter 1977) [Model]

Bers DM (2001) Excitation-Contraction Coupling and Cardiac Contractile Force (2nd edn)

Brown PB, Malhotra L (1978) A 60-Hz harmonic eliminator. IEEE Trans Biomed Eng 25:392-7 [Journal] [PubMed]

Carmeliet E (1999) Cardiac ionic currents and acute ischemia: from channels to arrhythmias. Physiol Rev 79:917-1017 [Journal] [PubMed]

DiFrancesco D, Noble D (1985) A model of cardiac electrical activity incorporating ionic pumps and concentration changes. Philos Trans R Soc Lond B Biol Sci 307:353-98 [Journal] [PubMed]

   Cardiac action potentials and pacemaker activity of sinoatrial node (DiFrancesco & Noble 1985) [Model]

Hilgemann DW, Noble D (1987) Excitation-contraction coupling and extracellular calcium transients in rabbit atrium: reconstruction of basic cellular mechanisms. Proc R Soc Lond B Biol Sci 230:163-205 [Journal] [PubMed]

Hiraoka M, Kawano S (1989) Calcium-sensitive and insensitive transient outward current in rabbit ventricular myocytes. J Physiol 410:187-212 [PubMed]

HODGKIN AL, HUXLEY AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117:500-44 [Journal] [PubMed]

   Squid axon (Hodgkin, Huxley 1952) (LabAXON) [Model]
   Squid axon (Hodgkin, Huxley 1952) (NEURON) [Model]
   Squid axon (Hodgkin, Huxley 1952) (SNNAP) [Model]
   Squid axon (Hodgkin, Huxley 1952) used in (Chen et al 2010) (R language) [Model]
   Squid axon (Hodgkin, Huxley 1952) (SBML, XPP, other) [Model]

Jafri MS, Rice JJ, Winslow RL (1998) Cardiac Ca2+ dynamics: the roles of ryanodine receptor adaptation and sarcoplasmic reticulum load. Biophys J 74:1149-68 [Journal] [PubMed]

Kawano S, Hiraoka M (1991) Transient outward currents and action potential alterations in rabbit ventricular myocytes. J Mol Cell Cardiol 23:681-93 [PubMed]

Kawano S, Hirayama Y, Hiraoka M (1995) Activation mechanism of Ca(2+)-sensitive transient outward current in rabbit ventricular myocytes. J Physiol 486 ( Pt 3):593-604

Lindblad DS, Murphey CR, Clark JW, Giles WR (1996) A model of the action potential and underlying membrane currents in a rabbit atrial cell. Am J Physiol 271:H1666-96 [Journal] [PubMed]

Luo CH, Rudy Y (1991) A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction. Circ Res 68:1501-26 [PubMed]

   Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]
   Cardiac action potential based on Luo-Rudy phase 1 model (Luo and Rudy 1991), (Wu 2004) [Model]

Luo CH, Rudy Y (1994) A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circ Res 74:1071-96 [PubMed]

   Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

McAllister RE, Noble D, Tsien RW (1975) Reconstruction of the electrical activity of cardiac Purkinje fibres. J Physiol 251:1-59 [PubMed]

Nerbonne JM (2000) Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium. J Physiol 525 Pt 2:285-98 [PubMed]

NOBLE D (1962) A modification of the Hodgkin--Huxley equations applicable to Purkinje fibre action and pace-maker potentials. J Physiol 160:317-52 [PubMed]

Noble D, Tsien RW (1968) The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres. J Physiol 195:185-214 [PubMed]

Nordin C (1993) Computer model of membrane current and intracellular Ca2+ flux in the isolated guinea pig ventricular myocyte. Am J Physiol 265:H2117-36 [Journal] [PubMed]

Nygren A, Fiset C, Firek L, Clark JW, Lindblad DS, Clark RB, Giles WR (2004) Mathematical model of an adult human atrial cell: the role of K+ currents in repolarization. Circ Res 82:63-81

Pogwizd SM, Chung MK, Cain ME (1997) Termination of ventricular tachycardia in the human heart. Insights from three-dimensional mapping of nonsustained and sustained ventricular tachycardias. Circulation 95:2528-40 [PubMed]

Pogwizd SM, Qi M, Yuan W, Samarel AM, Bers DM (1999) Upregulation of Na(+)/Ca(2+) exchanger expression and function in an arrhythmogenic rabbit model of heart failure. Circ Res 85:1009-19 [PubMed]

Pogwizd SM, Schlotthauer K, Li L, Yuan W, Bers DM (2001) Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness. Circ Res 88:1159-67 [PubMed]

Priebe L, Beuckelmann DJ (1998) Simulation study of cellular electric properties in heart failure. Circ Res 82:1206-23 [PubMed]

Puglisi JL, Pogwizd SM, Yuan W, Bers DM (2000) Increased Na-Ca exchange and reduced IK1 facilitate triggered action potentials in a rabbit model of heart failure Biophys J 78:55A

Puglisi JL, Yuan W, Bassani JW, Bers DM (1999) Ca(2+) influx through Ca(2+) channels in rabbit ventricular myocytes during action potential clamp: influence of temperature. Circ Res 85:e7-e16 [PubMed]

Shannon TR, Bers DM (2001) A mathematical model describes the SR load-dependence of Ca dynamics in cardiac myocytes Biophys J 80:594A

Shannon TR, Ginsburg KS, Bers DM (2000) Potentiation of fractional sarcoplasmic reticulum calcium release by total and free intra-sarcoplasmic reticulum calcium concentration. Biophys J 78:334-43 [Journal] [PubMed]

Shannon TR, Ginsburg KS, Bers DM (2000) Reverse mode of the sarcoplasmic reticulum calcium pump and load-dependent cytosolic calcium decline in voltage-clamped cardiac ventricular myocytes. Biophys J 78:322-33 [Journal] [PubMed]

Sipido KR, Callewaert G, Carmeliet E (1993) [Ca2+]i transients and [Ca2+]i-dependent chloride current in single Purkinje cells from rabbit heart. J Physiol 468:641-67

Trafford AW, Díaz ME, Eisner DA (1999) A novel, rapid and reversible method to measure Ca buffering and time-course of total sarcoplasmic reticulum Ca content in cardiac ventricular myocytes. Pflugers Arch 437:501-3 [Journal] [PubMed]

Trafford AW, Diaz ME, O'Neill SC, Eisner DA (1995) Comparison of subsarcolemmal and bulk calcium concentration during spontaneous calcium release in rat ventricular myocytes. J Physiol 488 ( Pt 3):577-86

Weber CR, Ginsburg KS, Philipson KD, Shannon TR, Bers DM (2001) Allosteric regulation of Na/Ca exchange current by cytosolic Ca in intact cardiac myocytes. J Gen Physiol 117:119-31 [PubMed]

Winslow RL, Rice J, Jafri S, Marbán E, O'Rourke B (1999) Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies. Circ Res 84:571-86 [PubMed]

   Kv4.3, Kv1.4 encoded K channel in heart cells & tachy. (Winslow et al 1999, Greenstein et al 2000) [Model]

Zeng J, Laurita KR, Rosenbaum DS, Rudy Y (1995) Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circ Res 77:140-52 [PubMed]

   Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Zygmunt AC, Gibbons WR (1991) Calcium-activated chloride current in rabbit ventricular myocytes. Circ Res 68:424-37 [PubMed]

Zygmunt AC, Gibbons WR (1992) Properties of the calcium-activated chloride current in heart. J Gen Physiol 99:391-414 [PubMed]

Busjahn A, Seebohm G, Maier G, Toliat MR, Nürnberg P, Aydin A, Luft FC, Lang F (2004) Association of the serum and glucocorticoid regulated kinase (sgk1) gene with QT interval. Cell Physiol Biochem 14:135-42 [Journal] [PubMed]

   A cardiac cell simulator (Puglisi and Bers 2001), applied to the QT interval (Busjahn et al 2004) [Model]

Mahajan A, Shiferaw Y, Sato D, Baher A, Olcese R, Xie LH, Yang MJ, Chen PS, Restrepo JG, Karma A, Garfinkel A, Qu Z, Weiss JN (2008) A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophys J 94:392-410 [Journal] [PubMed]

Patel SP, Campbell DL (2005) Transient outward potassium current, 'Ito', phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms. J Physiol 569:7-39 [Journal] [PubMed]

Winslow RL, Cortassa S, Greenstein JL (2005) Using models of the myocyte for functional interpretation of cardiac proteomic data. J Physiol 563:73-81 [Journal] [PubMed]

Winslow RL, Greenstein JL (2004) The ongoing journey to understand heart function through integrative modeling. Circ Res 95:1135-6 [Journal] [PubMed]

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