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Prescott SA, Sejnowski TJ, De Koninck Y (2006) Reduction of anion reversal potential subverts the inhibitory control of firing rate in spinal lamina I neurons: towards a biophysical basis for neuropathic pain. Mol Pain 2:32 [PubMed]

References and models cited by this paper

References and models that cite this paper

Andrew D, Craig AD (2002) Responses of spinothalamic lamina I neurons to maintained noxious mechanical stimulation in the cat. J Neurophysiol 87:1889-901 [Journal] [PubMed]

Antal M, Petkó M, Polgár E, Heizmann CW, Storm-Mathisen J (1996) Direct evidence of an extensive GABAergic innervation of the spinal dorsal horn by fibres descending from the rostral ventromedial medulla. Neuroscience 73:509-18 [PubMed]

Baba H, Ji RR, Kohno T, Moore KA, Ataka T, Wakai A, Okamoto M, Woolf CJ (2003) Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn. Mol Cell Neurosci 24:818-30 [PubMed]

Besson JM (1999) The neurobiology of pain. Lancet 353:1610-5 [PubMed]

Bester H, Chapman V, Besson JM, Bernard JF (2000) Physiological properties of the lamina I spinoparabrachial neurons in the rat. J Neurophysiol 83:2239-59 [Journal] [PubMed]

Block BM, Hurley RW, Raja SN (2004) Mechanism-based therapies for pain. Drug News Perspect 17:172-86 [PubMed]

Borg-Graham LJ, Monier C, Frégnac Y (1998) Visual input evokes transient and strong shunting inhibition in visual cortical neurons. Nature 393:369-73 [Journal] [PubMed]

Buesa I, Ortiz V, Aguilera L, Torre F, Zimmermann M, Azkue JJ (2006) Disinhibition of spinal responses to primary afferent input by antagonism at GABA receptors in urethane-anaesthetised rats is dependent on NMDA and metabotropic glutamate receptors. Neuropharmacology 50:585-94 [Journal] [PubMed]

Castro-Lopes JM, Tavares I, Coimbra A (1993) GABA decreases in the spinal cord dorsal horn after peripheral neurectomy. Brain Res 620:287-91 [PubMed]

Chance FS, Abbott LF, Reyes AD (2002) Gain modulation from background synaptic input. Neuron 35:773-82 [PubMed]

Chéry N, de Koninck Y (1999) Junctional versus extrajunctional glycine and GABA(A) receptor-mediated IPSCs in identified lamina I neurons of the adult rat spinal cord. J Neurosci 19:7342-55 [PubMed]

Chizh BA, Headley PM (2005) NMDA antagonists and neuropathic pain--multiple drug targets and multiple uses. Curr Pharm Des 11:2977-94 [PubMed]

Cordero-Erausquin M, Coull JA, Boudreau D, Rolland M, De Koninck Y (2005) Differential maturation of GABA action and anion reversal potential in spinal lamina I neurons: impact of chloride extrusion capacity. J Neurosci 25:9613-23 [Journal] [PubMed]

Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, Gravel C, Salter MW, De Koninck Y (2005) BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 438:1017-21 [Journal] [PubMed]

Coull JA, Boudreau D, Bachand K, Prescott SA, Nault F, Sík A, De Koninck P, De Koninck Y (2003) Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain. Nature 424:938-42 [Journal] [PubMed]

Craig AD (2003) Pain mechanisms: labeled lines versus convergence in central processing. Annu Rev Neurosci 26:1-30 [Journal] [PubMed]

Craig AD, Andrew D (2002) Responses of spinothalamic lamina I neurons to repeated brief contact heat stimulation in the cat. J Neurophysiol 87:1902-14 [Journal] [PubMed]

Craig AD, Kniffki KD (1985) Spinothalamic lumbosacral lamina I cells responsive to skin and muscle stimulation in the cat. J Physiol 365:197-221 [PubMed]

Craig AD, Krout K, Andrew D (2001) Quantitative response characteristics of thermoreceptive and nociceptive lamina I spinothalamic neurons in the cat. J Neurophysiol 86:1459-80 [Journal] [PubMed]

Cummins TR, Dib-Hajj SD, Black JA, Waxman SG (2000) Sodium channels and the molecular pathophysiology of pain. Prog Brain Res 129:3-19 [Journal] [PubMed]

Dahlhaus A, Ruscheweyh R, Sandkühler J (2005) Synaptic input of rat spinal lamina I projection and unidentified neurones in vitro. J Physiol 566:355-68 [Journal] [PubMed]

Destexhe A, Mainen ZF, Sejnowski TJ (1998) Kinetic models of synaptic transmission Methods In Neuronal Modeling, Koch C:Segev I, ed. pp.1

   Kinetic synaptic models applicable to building networks (Destexhe et al 1998) [Model]

Dickenson AH (1996) Balances between excitatory and inhibitory events in the spinal cord and chronic pain. Prog Brain Res 110:225-31 [PubMed]

Eaton MJ, Plunkett JA, Karmally S, Martinez MA, Montanez K (1998) Changes in GAD- and GABA- immunoreactivity in the spinal dorsal horn after peripheral nerve injury and promotion of recovery by lumbar transplant of immortalized serotonergic precursors. J Chem Neuroanat 16:57-72 [PubMed]

Eaton MJ, Plunkett JA, Martinez MA, Lopez T, Karmally S, Cejas P, Whittemore SR (2006) Transplants of neuronal cells bioengineered to synthesize GABA alleviate chronic neuropathic pain. Cell Transplant 8:87-101

Eccles JC (1964) Presynaptic inhibition The Physiology of synapses :220-238

Fukuoka T, Tokunaga A, Kondo E, Miki K, Tachibana T, Noguchi K (1998) Change in mRNAs for neuropeptides and the GABA(A) receptor in dorsal root ganglion neurons in a rat experimental neuropathic pain model. Pain 78:13-26 [PubMed]

Furue H, Katafuchi T, Yoshimura M (2004) Sensory processing and functional reorganization of sensory transmission under pathological conditions in the spinal dorsal horn. Neurosci Res 48:361-8 [Journal] [PubMed]

Furue H, Narikawa K, Kumamoto E, Yoshimura M (1999) Responsiveness of rat substantia gelatinosa neurones to mechanical but not thermal stimuli revealed by in vivo patch-clamp recording. J Physiol 521 Pt 2:529-35 [PubMed]

Game CJ, Lodge D (1975) The pharmacology of the inhibition of dorsal horn neurones by impulses in myelinated cutaneous afferents in the cat. Exp Brain Res 23:75-84 [PubMed]

Gulledge AT, Stuart GJ (2003) Excitatory actions of GABA in the cortex. Neuron 37:299-309 [PubMed]

Hao JX, Xu XJ, Aldskogius H, Seiger A, Wiesenfeld-Hallin Z (1991) Allodynia-like effects in rat after ischaemic spinal cord injury photochemically induced by laser irradiation. Pain 45:175-85 [PubMed]

Harden RN (2005) Chronic neuropathic pain. Mechanisms, diagnosis, and treatment. Neurologist 11:111-22 [Journal] [PubMed]

Harvey RJ, Depner UB, Wässle H, Ahmadi S, Heindl C, Reinold H, Smart TG, Harvey K, Schütz B, Abo-Salem OM, Zimmer A, Poisbeau P, Welzl H, Wolfer DP, Betz H, Zeilhofer HU, Müller U (2004) GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization. Science 304:884-7 [Journal] [PubMed]

Hines ML, Carnevale NT (1997) The NEURON simulation environment. Neural Comput 9:1179-209 [PubMed]

Hwang JH, Yaksh TL (1997) The effect of spinal GABA receptor agonists on tactile allodynia in a surgically-induced neuropathic pain model in the rat. Pain 70:15-22 [PubMed]

Ibuki T, Hama AT, Wang XT, Pappas GD, Sagen J (1997) Loss of GABA-immunoreactivity in the spinal dorsal horn of rats with peripheral nerve injury and promotion of recovery by adrenal medullary grafts. Neuroscience 76:845-58 [PubMed]

Isaev D, Gerber G, Park SK, Chung JM, Randik M (2000) Facilitation of NMDA-induced currents and Ca2+ transients in the rat substantia gelatinosa neurons after ligation of L5-L6 spinal nerves. Neuroreport 11:4055-61 [PubMed]

Jahr CE, Stevens CF (1990) A quantitative description of NMDA receptor-channel kinetic behavior. J Neurosci 10:1830-7 [PubMed]

Jahr CE, Stevens CF (1990) Voltage dependence of NMDA-activated macroscopic conductances predicted by single-channel kinetics. J Neurosci 10:3178-82 [PubMed]

Jarolimek W, Lewen A, Misgeld U (1999) A furosemide-sensitive K+-Cl- cotransporter counteracts intracellular Cl- accumulation and depletion in cultured rat midbrain neurons. J Neurosci 19:4695-704 [PubMed]

Jensen TS, Baron R (2003) Translation of symptoms and signs into mechanisms in neuropathic pain. Pain 102:1-8 [PubMed]

Julius D, Basbaum AI (2001) Molecular mechanisms of nociception. Nature 413:203-10 [Journal] [PubMed]

Kaila K, Lamsa K, Smirnov S, Taira T, Voipio J (1997) Long-lasting GABA-mediated depolarization evoked by high-frequency stimulation in pyramidal neurons of rat hippocampal slice is attributable to a network-driven, bicarbonate-dependent K+ transient. J Neurosci 17:7662-72 [PubMed]

Kalso E (2005) Sodium channel blockers in neuropathic pain. Curr Pharm Des 11:3005-11 [PubMed]

Keller AF, Coull JA, Chery N, Poisbeau P, De Koninck Y (2001) Region-specific developmental specialization of GABA-glycine cosynapses in laminas I-II of the rat spinal dorsal horn. J Neurosci 21:7871-80 [PubMed]

Koltzenburg M, Scadding J (2001) Neuropathic pain. Curr Opin Neurol 14:641-7

Kontinen VK, Stanfa LC, Basu A, Dickenson AH (2001) Electrophysiologic evidence for increased endogenous gabaergic but not glycinergic inhibitory tone in the rat spinal nerve ligation model of neuropathy. Anesthesiology 94:333-9 [PubMed]

Kuhn A, Aertsen A, Rotter S (2004) Neuronal integration of synaptic input in the fluctuation-driven regime. J Neurosci 24:2345-56 [Journal] [PubMed]

Lewin GR, Lu Y, Park TJ (2004) A plethora of painful molecules. Curr Opin Neurobiol 14:443-9 [Journal] [PubMed]

Lin Q, Peng YB, Willis WD (1996) Inhibition of primate spinothalamic tract neurons by spinal glycine and GABA is reduced during central sensitization. J Neurophysiol 76:1005-14 [Journal] [PubMed]

Loomis CW, Khandwala H, Osmond G, Hefferan MP (2001) Coadministration of intrathecal strychnine and bicuculline effects synergistic allodynia in the rat: an isobolographic analysis. J Pharmacol Exp Ther 296:756-61 [PubMed]

Mainen ZF, Joerges J, Huguenard JR, Sejnowski TJ (1995) A model of spike initiation in neocortical pyramidal neurons. Neuron 15:1427-39 [PubMed]

   Spike Initiation in Neocortical Pyramidal Neurons (Mainen et al 1995) [Model]

Mainen ZF, Sejnowski TJ (1996) Influence of dendritic structure on firing pattern in model neocortical neurons. Nature 382:363-6 [Journal] [PubMed]

   Influence of dendritic structure on neocortical neuron firing patterns (Mainen and Sejnowski 1996) [Model]

Malan TP, Mata HP, Porreca F (2002) Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain. Anesthesiology 96:1161-7 [PubMed]

McGowan MK, Hammond DL (1993) Intrathecal GABAB antagonists attenuate the antinociception produced by microinjection of L-glutamate into the ventromedial medulla of the rat. Brain Res 607:39-46 [PubMed]

Melzack R, Wall PD (1965) Pain mechanisms: a new theory. Science 150:971-9 [PubMed]

Miletic G, Draganic P, Pankratz MT, Miletic V (2003) Muscimol prevents long-lasting potentiation of dorsal horn field potentials in rats with chronic constriction injury exhibiting decreased levels of the GABA transporter GAT-1. Pain 105:347-53 [PubMed]

Moore KA, Kohno T, Karchewski LA, Scholz J, Baba H, Woolf CJ (2002) Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord. J Neurosci 22:6724-31 [Journal] [PubMed]

Morita K, Tsumoto K, Aihara K (2005) Possible effects of depolarizing GABAA conductance on the neuronal input-output relationship: a modeling study. J Neurophysiol 93:3504-23 [Journal] [PubMed]

Peng YB, Lin Q, Willis WD (1996) Effects of GABA and glycine receptor antagonists on the activity and PAG-induced inhibition of rat dorsal horn neurons. Brain Res 736:189-201 [PubMed]

Perl ER (1984) Pain and nociception Sensory processes, Darian-Smith I, ed. pp.915

Pezet S, McMahon SB (2006) Neurotrophins: mediators and modulators of pain. Annu Rev Neurosci 29:507-38 [Journal] [PubMed]

Poisbeau P, Patte-Mensah C, Keller AF, Barrot M, Breton JD, Luis-Delgado OE, Freund-Mercier MJ, Mensah-Nyagan AG, Schlichter R (2005) Inflammatory pain upregulates spinal inhibition via endogenous neurosteroid production. J Neurosci 25:11768-76 [Journal] [PubMed]

Polgár E, Gray S, Riddell JS, Todd AJ (2004) Lack of evidence for significant neuronal loss in laminae I-III of the spinal dorsal horn of the rat in the chronic constriction injury model. Pain 111:144-50 [Journal] [PubMed]

Polgár E, Hughes DI, Arham AZ, Todd AJ (2005) Loss of neurons from laminas I-III of the spinal dorsal horn is not required for development of tactile allodynia in the spared nerve injury model of neuropathic pain. J Neurosci 25:6658-66 [Journal] [PubMed]

Polgár E, Hughes DI, Riddell JS, Maxwell DJ, Puskár Z, Todd AJ (2003) Selective loss of spinal GABAergic or glycinergic neurons is not necessary for development of thermal hyperalgesia in the chronic constriction injury model of neuropathic pain. Pain 104:229-39 [PubMed]

Prescott SA, De Koninck Y (2002) Four cell types with distinctive membrane properties and morphologies in lamina I of the spinal dorsal horn of the adult rat. J Physiol 539:817-36 [PubMed]

Prescott SA, De Koninck Y (2003) Gain control of firing rate by shunting inhibition: roles of synaptic noise and dendritic saturation. Proc Natl Acad Sci U S A 100:2076-81 [Journal] [PubMed]

Prescott SA, De Koninck Y (2005) Integration time in a subset of spinal lamina I neurons is lengthened by sodium and calcium currents acting synergistically to prolong subthreshold depolarization. J Neurosci 25:4743-54 [Journal] [PubMed]

   Tonic neuron in spinal lamina I: prolongation of subthreshold depol. (Prescott and De Koninck 2005) [Model]

Price TJ, Cervero F, de Koninck Y (2005) Role of cation-chloride-cotransporters (CCC) in pain and hyperalgesia. Curr Top Med Chem 5:547-55 [PubMed]

Qian N, Sejnowski TJ (1990) When is an inhibitory synapse effective? Proc Natl Acad Sci U S A 87:8145-9 [PubMed]

Ralston DD, Behbehani M, Sehlhorst SC, Meng XW, Ralston HJ (1997) Decreased GABA immunoreactivity in rat dorsal horn is correlated with pain behavior: a light and electron microscope study, Jensen TS:Turner JA:Wiesenfeld-Hallin Z, ed. pp.547

Rode F, Jensen DG, Blackburn-Munro G, Bjerrum OJ (2005) Centrally-mediated antinociceptive actions of GABA(A) receptor agonists in the rat spared nerve injury model of neuropathic pain. Eur J Pharmacol 516:131-8 [Journal] [PubMed]

Sandkühler J (1996) Neurobiology of spinal nociception: new concepts. Prog Brain Res 110:207-24 [PubMed]

Seagrove LC, Suzuki R, Dickenson AH (2004) Electrophysiological characterisations of rat lamina I dorsal horn neurones and the involvement of excitatory amino acid receptors. Pain 108:76-87 [Journal] [PubMed]

Sherman SE, Loomis CW (1994) Morphine insensitive allodynia is produced by intrathecal strychnine in the lightly anesthetized rat. Pain 56:17-29 [PubMed]

Sherman SE, Loomis CW (1995) Strychnine-dependent allodynia in the urethane-anesthetized rat is segmentally distributed and prevented by intrathecal glycine and betaine. Can J Physiol Pharmacol 73:1698-705 [PubMed]

Sherman SE, Loomis CW (1996) Strychnine-sensitive modulation is selective for non-noxious somatosensory input in the spinal cord of the rat. Pain 66:321-30 [PubMed]

Sivilotti L, Woolf CJ (1994) The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord. J Neurophysiol 72:169-79 [Journal] [PubMed]

Slugg RM, Campbell JN, Meyer RA (2004) The population response of A- and C-fiber nociceptors in monkey encodes high-intensity mechanical stimuli. J Neurosci 24:4649-56 [Journal] [PubMed]

Smith PA (2004) Neuropathic pain: drug targets for current and future interventions. Drug News Perspect 17:5-17 [PubMed]

Somers DL, Clemente FR (2002) Dorsal horn synaptosomal content of aspartate, glutamate, glycine and GABA are differentially altered following chronic constriction injury to the rat sciatic nerve. Neurosci Lett 323:171-4 [PubMed]

Sorkin LS, Puig S (1996) Neuronal model of tactile allodynia produced by spinal strychnine: effects of excitatory amino acid receptor antagonists and a mu-opiate receptor agonist. Pain 68:283-92 [PubMed]

Sorkin LS, Puig S, Jones DL (1998) Spinal bicuculline produces hypersensitivity of dorsal horn neurons: effects of excitatory amino acid antagonists. Pain 77:181-90 [PubMed]

Staley KJ, Mody I (1992) Shunting of excitatory input to dentate gyrus granule cells by a depolarizing GABAA receptor-mediated postsynaptic conductance. J Neurophysiol 68:197-212 [Journal] [PubMed]

Staley KJ, Proctor WR (1999) Modulation of mammalian dendritic GABA(A) receptor function by the kinetics of Cl- and HCO3- transport. J Physiol 519 Pt 3:693-712 [PubMed]

Staley KJ, Soldo BL, Proctor WR (1995) Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors. Science 269:977-81 [PubMed]

Stiller CO, Cui JG, O'Connor WT, Brodin E, Meyerson BA, Linderoth B (1996) Release of gamma-aminobutyric acid in the dorsal horn and suppression of tactile allodynia by spinal cord stimulation in mononeuropathic rats. Neurosurgery 39:367-74; discussion 374-5 [PubMed]

Stubley LA, Martinez MA, Karmally S, Lopez T, Cejas P, Eaton MJ (2001) Only early intervention with gamma-aminobutyric acid cell therapy is able to reverse neuropathic pain after partial nerve injury. J Neurotrauma 18:471-7 [Journal] [PubMed]

Todd AJ (1996) GABA and glycine in synaptic glomeruli of the rat spinal dorsal horn. Eur J Neurosci 8:2492-8 [PubMed]

Torsney C, MacDermott AB (2006) Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord. J Neurosci 26:1833-43 [Journal] [PubMed]

Traub RD, Miles R (1991) Neuronal Networks Of The Hippocampus

Trevino DL (1976) The origin and projections of a spinal nociceptive and thermoreceptive pathway Sensory Functions of the Skin, Zotterman Y, ed. pp.367

Ugarte SD, Homanics GE, Firestone LL, Hammond DL (2000) Sensory thresholds and the antinociceptive effects of GABA receptor agonists in mice lacking the beta3 subunit of the GABA(A) receptor. Neuroscience 95:795-806 [PubMed]

Wiesenfeld-Hallin Z, Aldskogius H, Grant G, Hao JX, Hökfelt T, Xu XJ (1997) Central inhibitory dysfunctions: mechanisms and clinical implications. Behav Brain Sci 20:420-5; discussion 435-513 [PubMed]

Woolf CJ (2004) Dissecting out mechanisms responsible for peripheral neuropathic pain: implications for diagnosis and therapy. Life Sci 74:2605-10 [Journal] [PubMed]

Woolf CJ, American College of Physicians , American Physiological Society (2004) Pain: moving from symptom control toward mechanism-specific pharmacologic management. Ann Intern Med 140:441-51 [PubMed]

Woolf CJ, Bennett GJ, Doherty M, Dubner R, Kidd B, Koltzenburg M, Lipton R, Loeser JD, Payne R, Torebjork E (1998) Towards a mechanism-based classification of pain? Pain 77:227-9 [PubMed]

Woolf CJ, Mannion RJ (1999) Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet 353:1959-64 [Journal] [PubMed]

Woolf CJ, Salter MW (2000) Neuronal plasticity: increasing the gain in pain. Science 288:1765-9 [PubMed]

Woolf CJ, Wall PD (1982) Chronic peripheral nerve section diminishes the primary afferent A-fibre mediated inhibition of rat dorsal horn neurones. Brain Res 242:77-85 [PubMed]

Xu XJ, Hao JX, Aldskogius H, Seiger A, Wiesenfeld-Hallin Z (1992) Chronic pain-related syndrome in rats after ischemic spinal cord lesion: a possible animal model for pain in patients with spinal cord injury. Pain 48:279-90 [PubMed]

Yaksh TL (1989) Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists. Pain 37:111-23 [PubMed]

Yoshimura M, North RA (1983) Substantia gelatinosa neurones hyperpolarized in vitro by enkephalin. Nature 305:529-30 [PubMed]

Zeilhofer HU (2005) The glycinergic control of spinal pain processing. Cell Mol Life Sci 62:2027-35 [Journal] [PubMed]

Doyon N, Prescott SA, Castonguay A, Godin AG, Kröger H, De Koninck Y (2011) Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis. PLoS Comput Biol 7:e1002149 [Journal] [PubMed]

Gunn BG, Cox CD, Chen Y, Frotscher M, Gall CM, Baram TZ, Lynch G (2017) The Endogenous Stress Hormone CRH Modulates Excitatory Transmission and Network Physiology in Hippocampus. Cereb Cortex 27:4182-4198 [Journal] [PubMed]

   CRH modulates excitatory transmission and network physiology in hippocampus (Gunn et al. 2017) [Model]

Jedlicka P, Deller T, Gutkin BS, Backus KH (2011) Activity-dependent intracellular chloride accumulation and diffusion controls GABA(A) receptor-mediated synaptic transmission. Hippocampus 21:885-98 [Journal] [PubMed]

   Effects of Chloride accumulation and diffusion on GABAergic transmission (Jedlicka et al 2011) [Model]

Joos B, Barlow BM, Morris CE (2018) Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells. Handb Exp Pharmacol 246:401-422 [Journal] [PubMed]

   Calculating the consequences of left-shifted Nav channel activity in sick cells (Joos et al 2018) [Model]

Lewin N, Aksay E, Clancy CE (2012) Computational modeling reveals dendritic origins of GABA(A)-mediated excitation in CA1 pyramidal neurons. PLoS One 7:e47250 [Journal] [PubMed]

   Paradoxical GABA-mediated excitation (Lewin et al. 2012) [Model]

(111 refs)