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Busjahn A, Seebohm G, Maier G, Toliat MR, Nürnberg P, Aydin A, Luft FC, Lang F (2004) Association of the serum and glucocorticoid regulated kinase (sgk1) gene with QT interval. Cell Physiol Biochem 14:135-42 [PubMed]

   A cardiac cell simulator (Puglisi and Bers 2001), applied to the QT interval (Busjahn et al 2004)

References and models cited by this paper

References and models that cite this paper

Alvarez de la Rosa D, Zhang P, Náray-Fejes-Tóth A, Fejes-Tóth G, Canessa CM (1999) The serum and glucocorticoid kinase sgk increases the abundance of epithelial sodium channels in the plasma membrane of Xenopus oocytes. J Biol Chem 274:37834-9 [PubMed]

Baillard C, Mansier P, Ennezat PV, Mangin L, Medigue C, Swynghedauw B, Chevalier B (2000) Converting enzyme inhibition normalizes QT interval in spontaneously hypertensive rats. Hypertension 36:350-4 [PubMed]

Bazett HC (1920) An Analysis Of The Time Relations of Electrocardiograms 7:353-370

Bell LM, Leong ML, Kim B, Wang E, Park J, Hemmings BA, Firestone GL (2000) Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK-dependent pathway. J Biol Chem 275:25262-72

Berger S, Bleich M, Schmid W, Cole TJ, Peters J, Watanabe H, Kriz W, Warth R, Greger R, Schütz G (1998) Mineralocorticoid receptor knockout mice: pathophysiology of Na+ metabolism. Proc Natl Acad Sci U S A 95:9424-9 [PubMed]

Bhargava A, Fullerton MJ, Myles K, Purdy TM, Funder JW, Pearce D, Cole TJ (2001) The serum- and glucocorticoid-induced kinase is a physiological mediator of aldosterone action. Endocrinology 142:1587-94 [Journal] [PubMed]

Biondi RM, Kieloch A, Currie RA, Deak M, Alessi DR (2001) The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. EMBO J 20:4380-90 [Journal] [PubMed]

Blazer-Yost BL, Liu X, Helman SI (1998) Hormonal regulation of ENaCs: insulin and aldosterone. Am J Physiol 274:C1373-9 [Journal] [PubMed]

Blazer-Yost BL, Paunescu TG, Helman SI, Lee KD, Vlahos CJ (1999) Phosphoinositide 3-kinase is required for aldosterone-regulated sodium reabsorption. Am J Physiol 277:C531-6 [Journal] [PubMed]

Boehmer C, Wilhelm V, Palmada M, Wallisch S, Henke G, Brinkmeier H, Cohen P, Pieske B, Lang F (2003) Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A. Cardiovasc Res 57:1079-84 [PubMed]

Böhmer C, Wagner CA, Beck S, Moschen I, Melzig J, Werner A, Lin JT, Lang F, Wehner F (2000) The shrinkage-activated Na(+) conductance of rat hepatocytes and its possible correlation to rENaC. Cell Physiol Biochem 10:187-94 [Journal] [PubMed]

Boulkroun S, Fay M, Zennaro MC, Escoubet B, Jaisser F, Blot-Chabaud M, Farman N, Courtois-Coutry N (2002) Characterization of rat NDRG2 (N-Myc downstream regulated gene 2), a novel early mineralocorticoid-specific induced gene. J Biol Chem 277:31506-15 [Journal] [PubMed]

Brennan FE, Fuller PJ (2000) Rapid upregulation of serum and glucocorticoid-regulated kinase (sgk) gene expression by corticosteroids in vivo. Mol Cell Endocrinol 166:129-36 [PubMed]

Busjahn A, Aydin A, Uhlmann R, Krasko C, Bähring S, Szelestei T, Feng Y, Dahm S, Sharma AM, Luft FC, Lang F (2002) Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure. Hypertension 40:256-60 [PubMed]

Busjahn A, Knoblauch H, Faulhaber HD, Boeckel T, Rosenthal M, Uhlmann R, Hoehe M, Schuster H, Luft FC (1999) QT interval is linked to 2 long-QT syndrome loci in normal subjects. Circulation 99:3161-4 [PubMed]

Busjahn A, Luft FC (2003) Twin studies in the analysis of minor physiological differences between individuals. Cell Physiol Biochem 13:51-8 [Journal] [PubMed]

Chen SY, Bhargava A, Mastroberardino L, Meijer OC, Wang J, Buse P, Firestone GL, Verrey F, Pearce D (1999) Epithelial sodium channel regulated by aldosterone-induced protein sgk. Proc Natl Acad Sci U S A 96:2514-9 [PubMed]

Cooper MS, Bujalska I, Rabbitt E, Walker EA, Bland R, Sheppard MC, Hewison M, Stewart PM (2001) Modulation of 11beta-hydroxysteroid dehydrogenase isozymes by proinflammatory cytokines in osteoblasts: an autocrine switch from glucocorticoid inactivation to activation. J Bone Miner Res 16:1037-44 [Journal] [PubMed]

Cowling RT, Birnboim HC (2000) Expression of serum- and glucocorticoid-regulated kinase (sgk) mRNA is up-regulated by GM-CSF and other proinflammatory mediators in human granulocytes. J Leukoc Biol 67:240-8 [PubMed]

Debonneville C, Flores SY, Kamynina E, Plant PJ, Tauxe C, Thomas MA, Münster C, Chraïbi A, Pratt JH, Horisberger JD, Pearce D, Loffing J, Staub O (2001) Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression. EMBO J 20:7052-9 [Journal] [PubMed]

Embark HM, Böhmer C, Vallon V, Luft F, Lang F (2003) Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms. Pflugers Arch 445:601-6 [Journal] [PubMed]

Fillon S, Klingel K, Wärntges S, Sauter M, Gabrysch S, Pestel S, Tanneur V, Waldegger S, Zipfel A, Viebahn R, Häussinger D, Bröer S, Kandolf R, Lang F (2002) Expression of the serine/threonine kinase hSGK1 in chronic viral hepatitis. Cell Physiol Biochem 12:47-54 [Journal] [PubMed]

Firestone GL, Giampaolo JR, O'Keeffe BA (2003) Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity. Cell Physiol Biochem 13:1-12 [Journal] [PubMed]

Friedrich B, Feng Y, Cohen P, Risler T, Vandewalle A, Bröer S, Wang J, Pearce D, Lang F (2003) The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC. Pflugers Arch 445:693-6 [Journal] [PubMed]

Hansson JH, Nelson-Williams C, Suzuki H, Schild L, Shimkets R, Lu Y, Canessa C, Iwasaki T, Rossier B, Lifton RP (1995) Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nat Genet 11:76-82 [Journal] [PubMed]

Hayashi M, Tapping RI, Chao TH, Lo JF, King CC, Yang Y, Lee JD (2001) BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase. J Biol Chem 276:8631-4 [Journal] [PubMed]

Henke G, Setiawan I, Böhmer C, Lang F (2002) Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms. Kidney Blood Press Res 25:370-4 [Journal] [PubMed]

Hummler E, Barker P, Gatzy J, Beermann F, Verdumo C, Schmidt A, Boucher R, Rossier BC (1996) Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice. Nat Genet 12:325-8 [Journal] [PubMed]

Klingel K, Wärntges S, Bock J, Wagner CA, Sauter M, Waldegger S, Kandolf R, Lang F (2000) Expression of cell volume-regulated kinase h-sgk in pancreatic tissue. Am J Physiol Gastrointest Liver Physiol 279:G998-G1002 [Journal] [PubMed]

Kobayashi T, Cohen P (1999) Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. Biochem J 339 ( Pt 2):319-28

Kumari S, Liu X, Nguyen T, Zhang X, D'Mello SR (2001) Distinct phosphorylation patterns underlie Akt activation by different survival factors in neurons. Brain Res Mol Brain Res 96:157-62 [PubMed]

Lang F, Cohen P (2001) Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms. Sci STKE 2001:RE17-8

Lang F, Henke G, Embark HM, Waldegger S, Palmada M, Böhmer C, Vallon V (2003) Regulation of channels by the serum and glucocorticoid-inducible kinase - implications for transport, excitability and cell proliferation. Cell Physiol Biochem 13:41-50 [Journal] [PubMed]

Lang F, Klingel K, Wagner CA, Stegen C, Warntges S, Friedrich B, Lanzendorfer M, Melzig J, Moschen I, Steuer S, Waldegger S, Sauter M, Paulmichl M, Gerke V, Risler T, Gamba G, Capasso G, Kandolf R, Hebert SC, Massry SG, Broër S (2000) Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy. Proc Natl Acad Sci U S A 97:8157-62 [PubMed]

Lifton RP (1996) Molecular genetics of human blood pressure variation. Science 272:676-80 [PubMed]

Loffing J, Zecevic M, Féraille E, Kaissling B, Asher C, Rossier BC, Firestone GL, Pearce D, Verrey F (2001) Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK. Am J Physiol Renal Physiol 280:F675-82 [Journal] [PubMed]

Mikosz CA, Brickley DR, Sharkey MS, Moran TW, Conzen SD (2001) Glucocorticoid receptor-mediated protection from apoptosis is associated with induction of the serine/threonine survival kinase gene, sgk-1. J Biol Chem 276:16649-54 [Journal] [PubMed]

Nagy Z, Busjahn A, Bähring S, Faulhaber HD, Gohlke HR, Knoblauch H, Rosenthal M, Müller-Myhsok B, Schuster H, Luft FC (1999) Quantitative trait loci for blood pressure exist near the IGF-1, the Liddle syndrome, the angiotensin II-receptor gene and the renin loci in man. J Am Soc Nephrol 10:1709-16 [PubMed]

Náray-Fejes-Tóth A, Canessa C, Cleaveland ES, Aldrich G, Fejes-Tóth G (1999) sgk is an aldosterone-induced kinase in the renal collecting duct. Effects on epithelial na+ channels. J Biol Chem 274:16973-8 [PubMed]

Náray-Fejes-Tóth A, Fejes-Tóth G, Volk KA, Stokes JB (2000) SGK is a primary glucocorticoid-induced gene in the human. J Steroid Biochem Mol Biol 75:51-6 [PubMed]

Park J, Leong ML, Buse P, Maiyar AC, Firestone GL, Hemmings BA (1999) Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J 18:3024-33 [Journal] [PubMed]

Perrotti N, He RA, Phillips SA, Haft CR, Taylor SI (2001) Activation of serum- and glucocorticoid-induced protein kinase (Sgk) by cyclic AMP and insulin. J Biol Chem 276:9406-12 [Journal] [PubMed]

Piccirillo G, Germanò G, Quaglione R, Nocco M, Lintas F, Lionetti M, Moisè A, Ragazzo M, Marigliano V, Cacciafesta M (2002) QT-interval variability and autonomic control in hypertensive subjects with left ventricular hypertrophy. Clin Sci (Lond) 102:363-71 [PubMed]

Prasad N, Topping RS, Zhou D, Decker SJ (2000) Oxidative stress and vanadate induce tyrosine phosphorylation of phosphoinositide-dependent kinase 1 (PDK1). Biochemistry 39:6929-35 [PubMed]

Puglisi JL, Bers DM (2001) LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport. Am J Physiol Cell Physiol 281:C2049-60 [Journal] [PubMed]

   A cardiac cell simulator (Puglisi and Bers 2001), applied to the QT interval (Busjahn et al 2004) [Model]

Schild L, Lu Y, Gautschi I, Schneeberger E, Lifton RP, Rossier BC (1996) Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome. EMBO J 15:2381-7 [PubMed]

Seebohm G, Scherer CR, Busch AE, Lerche C (2001) Identification of specific pore residues mediating KCNQ1 inactivation. A novel mechanism for long QT syndrome. J Biol Chem 276:13600-5 [Journal] [PubMed]

Setiawan I, Henke G, Feng Y, Böhmer C, Vasilets LA, Schwarz W, Lang F (2002) Stimulation of Xenopus oocyte Na(+),K(+)ATPase by the serum and glucocorticoid-dependent kinase sgk1. Pflugers Arch 444:426-31 [Journal] [PubMed]

Shigaev A, Asher C, Latter H, Garty H, Reuveny E (2000) Regulation of sgk by aldosterone and its effects on the epithelial Na(+) channel. Am J Physiol Renal Physiol 278:F613-9 [Journal] [PubMed]

Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, Gill JR, Ulick S, Milora RV, Findling JW (1994) Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell 79:407-14 [PubMed]

Snyder PM, Olson DR, Thomas BC (2002) Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel. J Biol Chem 277:5-8 [Journal] [PubMed]

Snyder PM, Price MP, McDonald FJ, Adams CM, Volk KA, Zeiher BG, Stokes JB, Welsh MJ (1995) Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel. Cell 83:969-78 [PubMed]

Staub O, Gautschi I, Ishikawa T, Breitschopf K, Ciechanover A, Schild L, Rotin D (1997) Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination. EMBO J 16:6325-36 [Journal] [PubMed]

Vereninov AA, Vassilieva IO, Yurinskaya VE, Matveev VV, Glushankova LN, Lang F, Matskevitch JA (2001) Differential transcription of ion transporters, NHE1, ATP1B1, NKCC1 in human peripheral blood lymphocytes activated to proliferation. Cell Physiol Biochem 11:19-26 [Journal] [PubMed]

Vincent GM (1998) The molecular genetics of the long QT syndrome: genes causing fainting and sudden death. Annu Rev Med 49:263-74 [Journal] [PubMed]

Waerntges S, Klingel K, Weigert C, Fillon S, Buck M, Schleicher E, Rodemann HP, Knabbe C, Kandolf R, Lang F (2002) Excessive transcription of the human serum and glucocorticoid dependent kinase hSGK1 in lung fibrosis. Cell Physiol Biochem 12:135-42 [Journal] [PubMed]

Wagner CA, Ott M, Klingel K, Beck S, Melzig J, Friedrich B, Wild KN, Bröer S, Moschen I, Albers A, Waldegger S, Tümmler B, Egan ME, Geibel JP, Kandolf R, Lang F (2001) Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis. Cell Physiol Biochem 11:209-18 [Journal] [PubMed]

Waldegger S, Barth P, Raber G, Lang F (1997) Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume. Proc Natl Acad Sci U S A 94:4440-5 [PubMed]

Waldegger S, Gabrysch S, Barth P, Fillon S, Lang F (2000) h-sgk serine-threonine protein kinase as transcriptional target of p38/MAP kinase pathway in HepG2 human hepatoma cells. Cell Physiol Biochem 10:203-8 [Journal] [PubMed]

Waldegger S, Klingel K, Barth P, Sauter M, Rfer ML, Kandolf R, Lang F (1999) h-sgk serine-threonine protein kinase gene as transcriptional target of transforming growth factor beta in human intestine. Gastroenterology 116:1081-8 [PubMed]

Wang J, Barbry P, Maiyar AC, Rozansky DJ, Bhargava A, Leong M, Firestone GL, Pearce D (2001) SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport. Am J Physiol Renal Physiol 280:F303-13 [Journal] [PubMed]

Webster MK, Goya L, Firestone GL (1993) Immediate-early transcriptional regulation and rapid mRNA turnover of a putative serine/threonine protein kinase. J Biol Chem 268:11482-5 [PubMed]

Webster MK, Goya L, Ge Y, Maiyar AC, Firestone GL (1993) Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol Cell Biol 13:2031-40 [PubMed]

Wulff P, Vallon V, Huang DY, Völkl H, Yu F, Richter K, Jansen M, Schlünz M, Klingel K, Loffing J, Kauselmann G, Bösl MR, Lang F, Kuhl D (2002) Impaired renal Na(+) retention in the sgk1-knockout mouse. J Clin Invest 110:1263-8 [Journal] [PubMed]

Yee KM, Lim PO, Ogston SA, Struthers AD (2000) Effect of phenylephrine with and without atropine on QT dispersion in healthy normotensive men. Am J Cardiol 85:69-74 [PubMed]

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