Citation Relationships



Zhu ZI, Clancy CE (2007) L-type Ca2+ channel mutations and T-wave alternans: a model study. Am J Physiol Heart Circ Physiol 293:H3480-9 [PubMed]

   Ionic basis of alternans and Timothy Syndrome (Fox et al. 2002), (Zhu and Clancy 2007)

References and models cited by this paper

References and models that cite this paper

Alseikhan BA, DeMaria CD, Colecraft HM, Yue DT (2002) Engineered calmodulins reveal the unexpected eminence of Ca2+ channel inactivation in controlling heart excitation. Proc Natl Acad Sci U S A 99:17185-90 [Journal] [PubMed]

Berrou L, Bernatchez G, Parent L (2001) Molecular determinants of inactivation within the I-II linker of alpha1E (CaV2.3) calcium channels. Biophys J 80:215-28 [Journal] [PubMed]

Bondarenko VE, Szigeti GP, Bett GC, Kim SJ, Rasmusson RL (2004) Computer model of action potential of mouse ventricular myocytes. Am J Physiol Heart Circ Physiol 287:H1378-403 [Journal] [PubMed]

Branchaw JL, Banks MI, Jackson MB (1997) Ca2+- and voltage-dependent inactivation of Ca2+ channels in nerve terminals of the neurohypophysis. J Neurosci 17:5772-81 [PubMed]

Chinushi M, Restivo M, Caref EB, El-Sherif N (1998) Electrophysiological basis of arrhythmogenicity of QT/T alternans in the long-QT syndrome: tridimensional analysis of the kinetics of cardiac repolarization. Circ Res 83:614-28 [PubMed]

DeMaria CD, Soong TW, Alseikhan BA, Alvania RS, Yue DT (2001) Calmodulin bifurcates the local Ca2+ signal that modulates P/Q-type Ca2+ channels. Nature 411:484-9 [Journal] [PubMed]

Echebarria B, Karma A (2002) Instability and spatiotemporal dynamics of alternans in paced cardiac tissue. Phys Rev Lett 88:208101 [Journal] [PubMed]

El Habbal MH, Mahoney CO (2002) QT interval in children with sensory neural hearing loss. Pacing Clin Electrophysiol 25:435-9 [PubMed]

Faber GM, Silva J, Livshitz L, Rudy Y (2007) Kinetic properties of the cardiac L-type Ca2+ channel and its role in myocyte electrophysiology: a theoretical investigation. Biophys J 92:1522-43 [Journal] [PubMed]

Fabritz L, Kirchhof P, Franz MR, Nuyens D, Rossenbacker T, Ottenhof A, Haverkamp W, Breithardt G, Carmeliet E, Carmeliet P (2003) Effect of pacing and mexiletine on dispersion of repolarisation and arrhythmias in DeltaKPQ SCN5A (long QT3) mice. Cardiovasc Res 57:1085-93 [PubMed]

Findlay I (2004) Physiological modulation of inactivation in L-type Ca2+ channels: one switch. J Physiol 554:275-83 [Journal] [PubMed]

Fox JJ, McHarg JL, Gilmour RF (2002) Ionic mechanism of electrical alternans. Am J Physiol Heart Circ Physiol 282:H516-30 [Journal] [PubMed]

   Ionic basis of alternans and Timothy Syndrome (Fox et al. 2002), (Zhu and Clancy 2007) [Model]

Fox JJ, Riccio ML, Hua F, Bodenschatz E, Gilmour RF (2002) Spatiotemporal transition to conduction block in canine ventricle. Circ Res 90:289-96 [PubMed]

Hofmann F, Lacinová L, Klugbauer N (1999) Voltage-dependent calcium channels: from structure to function. Rev Physiol Biochem Pharmacol 139:33-87 [PubMed]

Hudmon A, Schulman H, Kim J, Maltez JM, Tsien RW, Pitt GS (2005) CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation. J Cell Biol 171:537-47 [Journal] [PubMed]

Imredy JP, Yue DT (1994) Mechanism of Ca(2+)-sensitive inactivation of L-type Ca2+ channels. Neuron 12:1301-18 [PubMed]

Karma A (1993) Spiral breakup in model equations of action potential propagation in cardiac tissue. Phys Rev Lett 71:1103-1106 [Journal] [PubMed]

Karma A (1994) Electrical alternans and spiral wave breakup in cardiac tissue. Chaos 4:461-472 [Journal] [PubMed]

Kim J, Ghosh S, Nunziato DA, Pitt GS (2004) Identification of the components controlling inactivation of voltage-gated Ca2+ channels. Neuron 41:745-54 [PubMed]

Koller ML, Riccio ML, Gilmour RF (1998) Dynamic restitution of action potential duration during electrical alternans and ventricular fibrillation. Am J Physiol 275:H1635-42 [Journal] [PubMed]

Liang H, DeMaria CD, Erickson MG, Mori MX, Alseikhan BA, Yue DT (2003) Unified mechanisms of Ca2+ regulation across the Ca2+ channel family. Neuron 39:951-60 [PubMed]

Lo-A-Njoe SM, Wilde AA, van Erven L, Blom NA (2005) Syndactyly and long QT syndrome (CaV1.2 missense mutation G406R) is associated with hypertrophic cardiomyopathy. Heart Rhythm 2:1365-8 [Journal] [PubMed]

Luo CH, Rudy Y (1991) A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction. Circ Res 68:1501-26 [PubMed]

   Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]
   Cardiac action potential based on Luo-Rudy phase 1 model (Luo and Rudy 1991), (Wu 2004) [Model]

Luo CH, Rudy Y (1994) A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circ Res 74:1071-96 [PubMed]

   Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Morad M, Soldatov N (2005) Calcium channel inactivation: possible role in signal transduction and Ca2+ signaling. Cell Calcium 38:223-31 [Journal] [PubMed]

Mori MX, Erickson MG, Yue DT (2004) Functional stoichiometry and local enrichment of calmodulin interacting with Ca2+ channels. Science 304:432-5 [Journal] [PubMed]

Nemec J, Ackerman MJ, Tester DJ, Hejlik J, Shen WK (2003) Catecholamine-provoked microvoltage T wave alternans in genotyped long QT syndrome. Pacing Clin Electrophysiol 26:1660-7 [PubMed]

Nolasco JB, Dahlen RW (1968) A graphic method for the study of alternation in cardiac action potentials. J Appl Physiol 25:191-6 [Journal] [PubMed]

Otani NF, Gilmour RF (1997) Memory models for the electrical properties of local cardiac systems. J Theor Biol 187:409-36 [PubMed]

Pastore JM, Girouard SD, Laurita KR, Akar FG, Rosenbaum DS (1999) Mechanism linking T-wave alternans to the genesis of cardiac fibrillation. Circulation 99:1385-94 [PubMed]

Pastore JM, Rosenbaum DS (2000) Role of structural barriers in the mechanism of alternans-induced reentry. Circ Res 87:1157-63 [PubMed]

Pitt GS, Zühlke RD, Hudmon A, Schulman H, Reuter H, Tsien RW (2001) Molecular basis of calmodulin tethering and Ca2+-dependent inactivation of L-type Ca2+ channels. J Biol Chem 276:30794-802 [Journal] [PubMed]

Plonsey RC (1988) Bioelectricity A Quantitative Approach

Priebe L, Beuckelmann DJ (1998) Simulation study of cellular electric properties in heart failure. Circ Res 82:1206-23 [PubMed]

Qu Z, Garfinkel A, Chen PS, Weiss JN (2000) Mechanisms of discordant alternans and induction of reentry in simulated cardiac tissue. Circulation 102:1664-70 [PubMed]

Satler CA, Vesely MR, Duggal P, Ginsburg GS, Beggs AH (1998) Multiple different missense mutations in the pore region of HERG in patients with long QT syndrome. Hum Genet 102:265-72 [PubMed]

Sato D, Shiferaw Y, Garfinkel A, Weiss JN, Qu Z, Karma A (2006) Spatially discordant alternans in cardiac tissue: role of calcium cycling. Circ Res 99:520-7 [Journal] [PubMed]

Sato D, Shiferaw Y, Qu Z, Garfinkel A, Weiss JN, Karma A (2007) Inferring the cellular origin of voltage and calcium alternans from the spatial scales of phase reversal during discordant alternans. Biophys J 92:L33-5 [Journal] [PubMed]

Shi C, Soldatov NM (2002) Molecular determinants of voltage-dependent slow inactivation of the Ca2+ channel. J Biol Chem 277:6813-21 [Journal] [PubMed]

Soldatov NM, Oz M, O'Brien KA, Abernethy DR, Morad M (1998) Molecular determinants of L-type Ca2+ channel inactivation. Segment exchange analysis of the carboxyl-terminal cytoplasmic motif encoded by exons 40-42 of the human alpha1C subunit gene. J Biol Chem 273:957-63 [PubMed]

Splawski I, Timothy KW, Decher N, Kumar P, Sachse FB, Beggs AH, Sanguinetti MC, Keating MT (2005) Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations. Proc Natl Acad Sci U S A 102:8089-96; discussion 8086-8 [Journal] [PubMed]

Splawski I, Timothy KW, Sharpe LM, Decher N, Kumar P, Bloise R, Napolitano C, Schwartz PJ, Joseph RM, Condouris K, Tager-Flusberg H, Priori SG, Sanguinetti MC, Keating MT (2004) Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell 119:19-31 [Journal] [PubMed]

Stotz SC, Zamponi GW (2001) Identification of inactivation determinants in the domain IIS6 region of high voltage-activated calcium channels. J Biol Chem 276:33001-10 [Journal] [PubMed]

ten Tusscher KH, Noble D, Noble PJ, Panfilov AV (2004) A model for human ventricular tissue. Am J Physiol Heart Circ Physiol 286:H1573-89 [Journal] [PubMed]

Watanabe MA, Fenton FH, Evans SJ, Hastings HM, Karma A (2001) Mechanisms for discordant alternans. J Cardiovasc Electrophysiol 12:196-206 [PubMed]

Zühlke RD, Pitt GS, Deisseroth K, Tsien RW, Reuter H (1999) Calmodulin supports both inactivation and facilitation of L-type calcium channels. Nature 399:159-62 [Journal] [PubMed]

Zuhlke RD, Pitt GS, Tsien RW, Reuter H (2000) Ca2+-sensitive inactivation and facilitation of L-type Ca2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the(alpha)1C subunit. J Biol Chem 275:21121-9

(47 refs)