Citation Relationships

Severi S, Corsi C, Rocchetti M, Zaza A (2009) Mechanisms of beta-adrenergic modulation of I(Ks) in the guinea-pig ventricle: insights from experimental and model-based analysis. Biophys J 96:3862-72 [PubMed]

   A model of beta-adrenergic modulation of IKs in the guinea-pig ventricle (Severi et al. 2009)

References and models cited by this paper

References and models that cite this paper

Aizawa Y, Ueda K, Scornik F, Cordeiro JM, Wu Y, Desai M, Guerchicoff A, Nagata Y, Iesaka Y, Kimura A, Hiraoka M, Antzelevitch C (2007) A novel mutation in KCNQ1 associated with a potent dominant negative effect as the basis for the LQT1 form of the long QT syndrome. J Cardiovasc Electrophysiol 18:972-7 [Journal] [PubMed]

Bosch RF, Gaspo R, Busch AE, Lang HJ, Li GR, Nattel S (1998) Effects of the chromanol 293B, a selective blocker of the slow, component of the delayed rectifier K+ current, on repolarization in human and guinea pig ventricular myocytes. Cardiovasc Res 38:441-50 [PubMed]

Brette F, Leroy J, Le Guennec JY, Salle L (2007) Ca2+ currents in cardiac myocytes: Old story, new insights. Prog Biophys Mol Biol 91:1-82

Carter S, Colyer J, Sitsapesan R (2006) Maximum phosphorylation of the cardiac ryanodine receptor at serine-2809 by protein kinase a produces unique modifications to channel gating and conductance not observed at lower levels of phosphorylation. Circ Res 98:1506-13 [Journal] [PubMed]

Chen H, Kim LA, Rajan S, Xu S, Goldstein SA (2003) Charybdotoxin binding in the I(Ks) pore demonstrates two MinK subunits in each channel complex. Neuron 40:15-23 [PubMed]

Chouabe C, Drici MD, Romey G, Barhanin J, Lazdunski M (1998) HERG and KvLQT1/IsK, the cardiac K+ channels involved in long QT syndromes, are targets for calcium channel blockers. Mol Pharmacol 54:695-703 [PubMed]

Derkach V, Barria A, Soderling TR (1999) Ca2+/calmodulin-kinase II enhances channel conductance of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors. Proc Natl Acad Sci U S A 96:3269-74 [PubMed]

Dilly KW, Kurokawa J, Terrenoire C, Reiken S, Lederer WJ, Marks AR, Kass RS (2004) Overexpression of beta2-adrenergic receptors cAMP-dependent protein kinase phosphorylates and modulates slow delayed rectifier potassium channels expressed in murine heart: evidence for receptor/channel co-localization. J Biol Chem 279:40778-87 [Journal] [PubMed]

Faber GM, Rudy Y (2000) Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophys J 78:2392-404 [Journal] [PubMed]

   Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Imredy JP, Penniman JR, Dech SJ, Irving WD, Salata JJ (2008) Modeling of the adrenergic response of the human IKs current (hKCNQ1/hKCNE1) stably expressed in HEK-293 cells. Am J Physiol Heart Circ Physiol 295:H1867-81 [Journal] [PubMed]

Iost N, Virág L, Opincariu M, Szécsi J, Varró A, Papp JG (1998) Delayed rectifier potassium current in undiseased human ventricular myocytes. Cardiovasc Res 40:508-15 [PubMed]

Lu Z, Kamiya K, Opthof T, Yasui K, Kodama I (2001) Density and kinetics of I(Kr) and I(Ks) in guinea pig and rabbit ventricular myocytes explain different efficacy of I(Ks) blockade at high heart rate in guinea pig and rabbit: implications for arrhythmogenesis in humans. Circulation 104:951-6 [PubMed]

Marx SO, Kurokawa J, Reiken S, Motoike H, D'Armiento J, Marks AR, Kass RS (2002) Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science 295:496-9 [Journal] [PubMed]

Moreno AP, Sáez JC, Fishman GI, Spray DC (1994) Human connexin43 gap junction channels. Regulation of unitary conductances by phosphorylation. Circ Res 74:1050-7 [PubMed]

Morin TJ, Kobertz WR (2008) Counting membrane-embedded KCNE beta-subunits in functioning K+ channel complexes. Proc Natl Acad Sci U S A 105:1478-82 [Journal] [PubMed]

Rocchetti M, Besana A, Gurrola GB, Possani LD, Zaza A (2001) Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential. J Physiol 534:721-32 [PubMed]

Rocchetti M, Freli V, Perego V, Altomare C, Mostacciuolo G, Zaza A (2006) Rate dependency of beta-adrenergic modulation of repolarizing currents in the guinea-pig ventricle. J Physiol 574:183-93 [Journal] [PubMed]

Sanguinetti MC, Jurkiewicz NK, Scott A, Siegl PK (1991) Isoproterenol antagonizes prolongation of refractory period by the class III antiarrhythmic agent E-4031 in guinea pig myocytes. Mechanism of action. Circ Res 68:77-84 [PubMed]

Saucerman JJ, Healy SN, Belik ME, Puglisi JL, McCulloch AD (2004) Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissue. Circ Res 95:1216-24 [Journal] [PubMed]

Schwartz PJ, Priori SG, Spazzolini C, Moss AJ, Vincent GM, Napolitano C, Denjoy I, Guicheney P, Breithardt G, Keating MT, Towbin JA, Beggs AH, Brink P, Wilde AA, Toivonen L, Zareba W, Robinson JL, Timothy KW, Corfield V, Wattanasirichaigoon D, Corbett C, Haverkamp W, Schulze-Bahr E, Lehmann MH, Schwartz K, Coumel P, Bloise R (2001) Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation 103:89-95 [PubMed]

Seebohm G, Strutz-Seebohm N, Birkin R, Dell G, Bucci C, Spinosa MR, Baltaev R, Mack AF, Korniychuk G, Choudhury A, Marks D, Pagano RE, Attali B, Pfeufer A, Kass RS, Sanguinetti MC, Tavare JM, Lang F (2007) Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels. Circ Res 100:686-92 [Journal] [PubMed]

Silva J, Rudy Y (2005) Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve. Circulation 112:1384-91 [Journal] [PubMed]

   Role of KCNQ1 and IKs in cardiac repolarization (Silva, Rudy 2005) [Model]
   Role of KCNQ1 and IKs in cardiac repolarization (Silva, Rudy 2005) (XPP) [Model]

Silverman WR, Roux B, Papazian DM (2003) Structural basis of two-stage voltage-dependent activation in K+ channels. Proc Natl Acad Sci U S A 100:2935-40 [Journal] [PubMed]

Terrenoire C, Clancy CE, Cormier JW, Sampson KJ, Kass RS (2005) Autonomic control of cardiac action potentials: role of potassium channel kinetics in response to sympathetic stimulation. Circ Res 96:e25-34 [Journal] [PubMed]

Tzounopoulos T, Maylie J, Adelman JP (1998) Gating of I(sK) channels expressed in Xenopus oocytes. Biophys J 74:2299-305 [Journal] [PubMed]

Varro A, Baláti B, Iost N, Takács J, Virág L, Lathrop DA, Csaba L, Tálosi L, Papp JG (2000) The role of the delayed rectifier component IKs in dog ventricular muscle and Purkinje fibre repolarization. J Physiol 523 Pt 1:67-81 [PubMed]

Volders PG, Stengl M, van Opstal JM, Gerlach U, Spätjens RL, Beekman JD, Sipido KR, Vos MA (2003) Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation. Circulation 107:2753-60 [Journal] [PubMed]

Walsh KB, Kass RS (1991) Distinct voltage-dependent regulation of a heart-delayed IK by protein kinases A and C. Am J Physiol 261:C1081-90 [Journal] [PubMed]

Wang Q, Curran ME, Splawski I, Burn TC, Millholland JM, VanRaay TJ, Shen J, Timothy KW, Vincent GM, de Jager T, Schwartz PJ, Toubin JA, Moss AJ, Atkinson DL, Landes GM, Connors TD, Keating MT (1996) Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet 12:17-23 [Journal] [PubMed]

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