References and models cited by this paper

References and models that cite this paper

Anderson JC, Binzegger T, Douglas RJ, Martin KA (2002) Chance or design? Some specific considerations concerning synaptic boutons in cat visual cortex. J Neurocytol 31:211-29 [PubMed]

Arellano JI, Benavides-Piccione R, Defelipe J, Yuste R (2007) Ultrastructure of dendritic spines: correlation between synaptic and spine morphologies. Front Neurosci 1:131-43 [Journal] [PubMed]

Beierlein M, Connors BW (2002) Short-term dynamics of thalamocortical and intracortical synapses onto layer 6 neurons in neocortex. J Neurophysiol 88:1924-32 [Journal] [PubMed]

Bienenstock EL, Cooper LN, Munro PW (1982) Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex. J Neurosci 2:32-48 [PubMed]

Bonhoeffer T, Staiger V, Aertsen A (1989) Synaptic plasticity in rat hippocampal slice cultures: local "Hebbian" conjunction of pre- and postsynaptic stimulation leads to distributed synaptic enhancement. Proc Natl Acad Sci U S A 86:8113-7 [PubMed]

Bopp R, Maçarico da Costa N, Kampa BM, Martin KA, Roth MM (2014) Pyramidal cells make specific connections onto smooth (GABAergic) neurons in mouse visual cortex. PLoS Biol 12:e1001932 [Journal] [PubMed]

Braitenberg V (2001) Brain size and number of neurons: an exercise in synthetic neuroanatomy. J Comput Neurosci 10:71-7 [PubMed]

Braitenberg V, Schuz A (1998) Cortex Statistics and Geometry of Neuronal Connectivity 2nd ed

Chklovskii DB, Mel BW, Svoboda K (2004) Cortical rewiring and information storage. Nature 431:782-8 [Journal] [PubMed]

Chklovskii DB, Vitaladevuni S, Scheffer LK (2010) Semi-automated reconstruction of neural circuits using electron microscopy. Curr Opin Neurobiol 20:667-75 [Journal] [PubMed]

DeFelipe J (1999) Chandelier cells and epilepsy. Brain 122 ( Pt 10):1807-22 [PubMed]

Denk W, Horstmann H (2004) Serial block-face scanning electron microscopy to reconstruct three-dimensional tissue nanostructure. PLoS Biol 2:e329 [Journal] [PubMed]

Deuchars J, West DC, Thomson AM (1994) Relationships between morphology and physiology of pyramid-pyramid single axon connections in rat neocortex in vitro. J Physiol 478 Pt 3:423-35 [PubMed]

Egger R, Dercksen VJ, Udvary D, Hege HC, Oberlaender M (2014) Generation of dense statistical connectomes from sparse morphological data. Front Neuroanat 8:129 [Journal] [PubMed]

Fares T, Stepanyants A (2009) Cooperative synapse formation in the neocortex. Proc Natl Acad Sci U S A 106:16463-8 [Journal] [PubMed]

Feldmeyer D, Egger V, Lubke J, Sakmann B (1999) Reliable synaptic connections between pairs of excitatory layer 4 neurones within a single 'barrel' of developing rat somatosensory cortex. J Physiol 521 Pt 1:169-90 [PubMed]

Feldmeyer D, Lübke J, Sakmann B (2006) Efficacy and connectivity of intracolumnar pairs of layer 2/3 pyramidal cells in the barrel cortex of juvenile rats. J Physiol 575:583-602 [Journal] [PubMed]

Feldmeyer D, Lübke J, Silver RA, Sakmann B (2002) Synaptic connections between layer 4 spiny neurone-layer 2/3 pyramidal cell pairs in juvenile rat barrel cortex: physiology and anatomy of interlaminar signalling within a cortical column. J Physiol 538:803-22 [PubMed]

Fino E, Yuste R (2011) Dense inhibitory connectivity in neocortex. Neuron 69:1188-203 [Journal] [PubMed]

Frick A, Feldmeyer D, Helmstaedter M, Sakmann B (2008) Monosynaptic connections between pairs of L5A pyramidal neurons in columns of juvenile rat somatosensory cortex. Cereb Cortex 18:397-406 [Journal] [PubMed]

Gupta A, Wang Y, Markram H (2000) Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex. Science 287:273-8 [PubMed]

Hellwig B (2000) A quantitative analysis of the local connectivity between pyramidal neurons in layers 2/3 of the rat visual cortex. Biol Cybern 82:111-21 [Journal] [PubMed]

Hill SL, Wang Y, Riachi I, Schürmann F, Markram H (2012) Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits. Proc Natl Acad Sci U S A 109:E2885-94 [Journal] [PubMed]

Hofer SB, Mrsic-Flogel TD, Bonhoeffer T, Hübener M (2009) Experience leaves a lasting structural trace in cortical circuits. Nature 457:313-7 [Journal] [PubMed]

Holmgren C, Harkany T, Svennenfors B, Zilberter Y (2003) Pyramidal cell communication within local networks in layer 2/3 of rat neocortex. J Physiol 551:139-53 [Journal] [PubMed]

Holtmaat A, Svoboda K (2009) Experience-dependent structural synaptic plasticity in the mammalian brain. Nat Rev Neurosci 10:647-58 [Journal] [PubMed]

Howard A, Tamas G, Soltesz I (2005) Lighting the chandelier: new vistas for axo-axonic cells. Trends Neurosci 28:310-6 [Journal] [PubMed]

Kalisman N, Silberberg G, Markram H (2005) The neocortical microcircuit as a tabula rasa. Proc Natl Acad Sci U S A 102:880-5 [Journal] [PubMed]

Karube F, Kubota Y, Kawaguchi Y (2004) Axon branching and synaptic bouton phenotypes in GABAergic nonpyramidal cell subtypes. J Neurosci 24:2853-65 [Journal] [PubMed]

Kawaguchi Y, Karube F, Kubota Y (2006) Dendritic branch typing and spine expression patterns in cortical nonpyramidal cells. Cereb Cortex 16:696-711 [Journal] [PubMed]

Kleinfeld D, Bharioke A, Blinder P, Bock DD, Briggman KL, Chklovskii DB, Denk W, Helmstaedter M, Kaufhold JP, Lee WC, Meyer HS, Micheva KD, Oberlaender M, Prohaska S, Reid RC, Smith SJ, Takemura S, Tsai PS, Sakmann B (2011) Large-scale automated histology in the pursuit of connectomes. J Neurosci 31:16125-38 [Journal] [PubMed]

Kozloski J, Hamzei-Sichani F, Yuste R (2001) Stereotyped position of local synaptic targets in neocortex. Science 293:868-72 [Journal] [PubMed]

Kozloski J, Sfyrakis K, Hill S, Schurmann F, Peck C, Markram H (2008) Identifying, tabulating, and analyzing contacts between branched neuron morphologies Ibm J Res Dev 52:43-55

Kubota Y, Hatada S, Kondo S, Karube F, Kawaguchi Y (2007) Neocortical inhibitory terminals innervate dendritic spines targeted by thalamocortical afferents. J Neurosci 27:1139-50 [Journal] [PubMed]

Lamprecht R, LeDoux J (2004) Structural plasticity and memory. Nat Rev Neurosci 5:45-54 [Journal] [PubMed]

Le Bé JV, Markram H (2006) Spontaneous and evoked synaptic rewiring in the neonatal neocortex. Proc Natl Acad Sci U S A 103:13214-9 [Journal] [PubMed]

Le Bé JV, Silberberg G, Wang Y, Markram H (2007) Morphological, electrophysiological, and synaptic properties of corticocallosal pyramidal cells in the neonatal rat neocortex. Cereb Cortex 17:2204-13 [Journal] [PubMed]

Lübke J, Roth A, Feldmeyer D, Sakmann B (2003) Morphometric analysis of the columnar innervation domain of neurons connecting layer 4 and layer 2/3 of juvenile rat barrel cortex. Cereb Cortex 13:1051-63 [PubMed]

Markram H, Lübke J, Frotscher M, Roth A, Sakmann B (1997) Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex. J Physiol 500 ( Pt 2):409-40 [PubMed]

Markram H, Muller E, Ramaswamy S, Reimann MW, Abdellah M, Sanchez CA, Ailamaki A, Alonso-Nanclares L, Antille N, Arsever S, Kahou GA, Berger TK, Bilgili A, Buncic N, Chalimourda A, Chindemi G, Courcol JD, Delalondre F, Delattre V, Druckmann S, Dumusc R, Dynes J, Eilemann S, Gal E, Gevaert ME, Ghobril JP, Gidon A, Graham JW, Gupta A, Haenel V, Hay E, Heinis T, Hernando JB, Hines M, Kanari L, Keller D, Kenyon J, Khazen G, Kim Y, King JG, Kisvarday Z, Kumbhar P, Lasserre S, Le Bé JV, Magalhães BR, Merchán-Pérez A, Meystre J, Morrice BR, Muller J, Muñoz-Céspedes A, Muralidhar S, Muthurasa K, Nachbaur D, Newton TH, Nolte M, Ovcharenko A, Palacios J, Pastor L, Perin R, Ranjan R, Riachi I, Rodríguez JR, Riquelme JL, Rössert C, Sfyrakis K, Shi Y, Shillcock JC, Silberberg G, Silva R, Tauheed F, Telefont M, Toledo-Rodriguez M, Tränkler T, Van Geit W, Díaz JV, Walker R, Wang Y, Zaninetta SM (2015) Reconstruction and Simulation of Neocortical Microcircuitry. Cell 163:456-92 [Journal] [PubMed]

Markram H, Toledo-Rodriguez M, Wang Y, Gupta A, Silberberg G, Wu C (2004) Interneurons of the neocortical inhibitory system. Nat Rev Neurosci 5:793-807 [Journal] [PubMed]

Mishchenko Y, Hu T, Spacek J, Mendenhall J, Harris KM, Chklovskii DB (2010) Ultrastructural analysis of hippocampal neuropil from the connectomics perspective. Neuron 67:1009-20 [Journal] [PubMed]

Neves G, Cooke SF, Bliss TV (2008) Synaptic plasticity, memory and the hippocampus: a neural network approach to causality. Nat Rev Neurosci 9:65-75 [Journal] [PubMed]

Nimchinsky EA, Sabatini BL, Svoboda K (2002) Structure and function of dendritic spines. Annu Rev Physiol 64:313-53 [Journal] [PubMed]

Perin R, Berger TK, Markram H (2011) A synaptic organizing principle for cortical neuronal groups. Proc Natl Acad Sci U S A 108:5419-24 [Journal] [PubMed]

Peters A, Feldman ML (1976) The projection of the lateral geniculate nucleus to area 17 of the rat cerebral cortex. I. General description. J Neurocytol 5:63-84 [PubMed]

Peters A, Proskauer CC, Feldman ML, Kimerer L (1979) The projection of the lateral geniculate nucleus to area 17 of the rat cerebral cortex. V. Degenerating axon terminals synapsing with Golgi impregnated neurons. J Neurocytol 8:331-57 [PubMed]

Petersen CC, Sakmann B (2000) The excitatory neuronal network of rat layer 4 barrel cortex. J Neurosci 20:7579-86 [PubMed]

Reyes A, Sakmann B (1999) Developmental switch in the short-term modification of unitary EPSPs evoked in layer 2/3 and layer 5 pyramidal neurons of rat neocortex. J Neurosci 19:3827-35 [PubMed]

Romand S, Wang Y, Toledo-Rodriguez M, Markram H (2011) Morphological development of thick-tufted layer v pyramidal cells in the rat somatosensory cortex. Front Neuroanat 5:5 [Journal] [PubMed]

Royer S, Paré D (2003) Conservation of total synaptic weight through balanced synaptic depression and potentiation. Nature 422:518-22 [Journal] [PubMed]

Sala C, Segal M (2014) Dendritic spines: the locus of structural and functional plasticity. Physiol Rev 94:141-88 [Journal] [PubMed]

Schuman EM, Madison DV (1994) Locally distributed synaptic potentiation in the hippocampus. Science 263:532-6 [PubMed]

Seung S () Connectome: How the Brain’s Wiring Makes Us Who We are

Shepherd GM, Stepanyants A, Bureau I, Chklovskii D, Svoboda K (2005) Geometric and functional organization of cortical circuits. Nat Neurosci 8:782-90 [Journal] [PubMed]

Silberberg G, Markram H (2007) Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells. Neuron 53:735-46 [Journal] [PubMed]

Silver RA, Lubke J, Sakmann B, Feldmeyer D (2003) High-probability uniquantal transmission at excitatory synapses in barrel cortex. Science 302:1981-4 [Journal] [PubMed]

Somogyi P (1977) A specific 'axo-axonal' interneuron in the visual cortex of the rat. Brain Res 136:345-50 [PubMed]

Somogyi P, Freund TF, Cowey A (1982) The axo-axonic interneuron in the cerebral cortex of the rat, cat and monkey. Neuroscience 7:2577-607 [PubMed]

Somogyi P, Tamás G, Lujan R, Buhl EH (1998) Salient features of synaptic organisation in the cerebral cortex. Brain Res Brain Res Rev 26:113-35 [PubMed]

Stepanyants A, Chklovskii DB (2005) Neurogeometry and potential synaptic connectivity. Trends Neurosci 28:387-94 [Journal] [PubMed]

Stepanyants A, Hof PR, Chklovskii DB (2002) Geometry and structural plasticity of synaptic connectivity. Neuron 34:275-88 [PubMed]

Szabadics J, Varga C, Molnár G, Oláh S, Barzó P, Tamás G (2006) Excitatory effect of GABAergic axo-axonic cells in cortical microcircuits. Science 311:233-5 [Journal] [PubMed]

Tauheed F,Biveinis L,Heinis T,Schu¨rmann F,Markram H, Ailamaki A (2012) Accelerating range queries for brain simulations Proceedings of the 28th International Conference on Data Engineering Washington DC :941-952

van Ooyen A, Carnell A, de Ridder S, Tarigan B, Mansvelder HD, Bijma F, de Gunst M, van Pelt J (2014) Independently outgrowing neurons and geometry-based synapse formation produce networks with realistic synaptic connectivity. PLoS One 9:e85858 [Journal] [PubMed]

Wang Y, Gupta A, Toledo-Rodriguez M, Wu CZ, Markram H (2002) Anatomical, physiological, molecular and circuit properties of nest basket cells in the developing somatosensory cortex. Cereb Cortex 12:395-410 [PubMed]

White G, Levy WB, Steward O (1990) Spatial overlap between populations of synapses determines the extent of their associative interaction during the induction of long-term potentiation and depression. J Neurophysiol 64:1186-98 [Journal] [PubMed]

Wilbrecht L, Holtmaat A, Wright N, Fox K, Svoboda K (2010) Structural plasticity underlies experience-dependent functional plasticity of cortical circuits. J Neurosci 30:4927-32 [Journal] [PubMed]

Barros-Zulaica N, Rahmon J, Chindemi G, Perin R, Markram H, Muller E, Ramaswamy S (2019) Estimating the Readily-Releasable Vesicle Pool Size at Synaptic Connections in the Neocortex Frontiers in Synaptic Neuroscience 11:29 [Journal]

Jacob T, Lillis KP, Wang Z, Swiercz W, Rahmati N, Staley KJ (2019) A Proposed Mechanism for Spontaneous Transitions between Interictal and Ictal Activity. J Neurosci 39:557-575 [Journal] [PubMed]

Markram H, Muller E, Ramaswamy S, Reimann MW, Abdellah M, Sanchez CA, Ailamaki A, Alonso-Nanclares L, Antille N, Arsever S, Kahou GA, Berger TK, Bilgili A, Buncic N, Chalimourda A, Chindemi G, Courcol JD, Delalondre F, Delattre V, Druckmann S, Dumusc R, Dynes J, Eilemann S, Gal E, Gevaert ME, Ghobril JP, Gidon A, Graham JW, Gupta A, Haenel V, Hay E, Heinis T, Hernando JB, Hines M, Kanari L, Keller D, Kenyon J, Khazen G, Kim Y, King JG, Kisvarday Z, Kumbhar P, Lasserre S, Le Bé JV, Magalhães BR, Merchán-Pérez A, Meystre J, Morrice BR, Muller J, Muñoz-Céspedes A, Muralidhar S, Muthurasa K, Nachbaur D, Newton TH, Nolte M, Ovcharenko A, Palacios J, Pastor L, Perin R, Ranjan R, Riachi I, Rodríguez JR, Riquelme JL, Rössert C, Sfyrakis K, Shi Y, Shillcock JC, Silberberg G, Silva R, Tauheed F, Telefont M, Toledo-Rodriguez M, Tränkler T, Van Geit W, Díaz JV, Walker R, Wang Y, Zaninetta SM (2015) Reconstruction and Simulation of Neocortical Microcircuitry. Cell 163:456-92 [Journal] [PubMed]

Reimann MW, Horlemann AL, Ramaswamy S, Muller EB, Markram H (2017) Morphological Diversity Strongly Constrains Synaptic Connectivity and Plasticity. Cereb Cortex 27:4570-4585 [Journal] [PubMed]

Reimann MW, Nolte M, Scolamiero M, Turner K, Perin R, Chindemi G, Dlotko P, Levi R, Hess K, Markram H (2017) Cliques of Neurons Bound into Cavities Provide a Missing Link between Structure and Function. Front Comput Neurosci 11:48 [Journal] [PubMed]