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Patel SP, Campbell DL (2005) Transient outward potassium current, 'Ito', phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms. J Physiol 569:7-39 [PubMed]

References and models cited by this paper

References and models that cite this paper

Aldrich RW (1981) Inactivation of voltage-gated delayed potassium current in molluscan neurons. A kinetic model. Biophys J 36:519-32 [Journal] [PubMed]

An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (2000) Modulation of A-type potassium channels by a family of calcium sensors. Nature 403:553-6 [Journal] [PubMed]

Anderson AE, Adams JP, Qian Y, Cook RG, Pfaffinger PJ, Sweatt JD (2000) Kv4.2 phosphorylation by cyclic AMP-dependent protein kinase. J Biol Chem 275:5337-46 [PubMed]

Antzelevitch C, Zygmunt AC, Dumaine R (2003) Electrophysiology and pharmacology of ventricular repolarization Cardiac Repolarization, Gussak I:Antzelevitch C, ed. pp.63

Archer SL, Rusch NJ (2001) Potassium Channels in Cardiovascular Biology

Bähring R, Boland LM, Varghese A, Gebauer M, Pongs O (2001) Kinetic analysis of open- and closed-state inactivation transitions in human Kv4.2 A-type potassium channels. J Physiol 535:65-81 [PubMed]

Bähring R, Dannenberg J, Peters HC, Leicher T, Pongs O, Isbrandt D (2001) Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating. J Biol Chem 276:23888-94 [Journal] [PubMed]

Baker OS, Larsson HP, Mannuzzu LM, Isacoff EY (1998) Three transmembrane conformations and sequence-dependent displacement of the S4 domain in shaker K+ channel gating. Neuron 20:1283-94 [PubMed]

Barry DM, Xu H, Schuessler RB, Nerbonne JM (1998) Functional knockout of the transient outward current, long-QT syndrome, and cardiac remodeling in mice expressing a dominant-negative Kv4 alpha subunit. Circ Res 83:560-7 [PubMed]

Bassani RA, Altamirano J, Puglisi JL, Bers DM (2004) Action potential duration determines sarcoplasmic reticulum Ca2+ reloading in mammalian ventricular myocytes. J Physiol 559:593-609 [Journal] [PubMed]

Beck EJ, Bowlby M, An WF, Rhodes KJ, Covarrubias M (2002) Remodelling inactivation gating of Kv4 channels by KChIP1, a small-molecular-weight calcium-binding protein. J Physiol 538:691-706 [PubMed]

Beck EJ, Covarrubias M (2001) Kv4 channels exhibit modulation of closed-state inactivation in inside-out patches. Biophys J 81:867-83 [Journal] [PubMed]

Bernard C, Legros C, Ferrat G, Bischoff U, Marquardt A, Pongs O, Darbon H (2000) Solution structure of hpTX2, a toxin from Heteropoda venatoria spider that blocks Kv4.2 potassium channel. Protein Sci 9:2059-67 [PubMed]

Bers DM (2001) Excitation-Contraction Coupling and Cardiac Contractile Force (2nd edn)

Bett GC, Rasmusson RL (2004) Inactivation and recovery in Kv1.4 K+ channels: lipophilic interactions at the intracellular mouth of the pore. J Physiol 556:109-20 [Journal] [PubMed]

Bezanilla F (2000) The voltage sensor in voltage-dependent ion channels. Physiol Rev 80:555-92 [Journal] [PubMed]

Bezanilla F (2002) Voltage sensor movements. J Gen Physiol 120:465-73 [PubMed]

Bezanilla F, Perozo E (2003) The voltage sensor and the gate in ion channels. Adv Protein Chem 63:211-41 [PubMed]

Birnbaum SG, Varga AW, Yuan LL, Anderson AE, Sweatt JD, Schrader LA (2004) Structure and function of Kv4-family transient potassium channels. Physiol Rev 84:803-33 [Journal] [PubMed]

Blaustein RO, Miller C (2004) Ion channels: shake, rattle or roll? Nature 427:499-500 [Journal] [PubMed]

Bondarenko VE, Szigeti GP, Bett GC, Kim SJ, Rasmusson RL (2004) Computer model of action potential of mouse ventricular myocytes. Am J Physiol Heart Circ Physiol 287:H1378-403 [Journal] [PubMed]

Bourne Y, Dannenberg J, Pollmann V, Marchot P, Pongs O (2001) Immunocytochemical localization and crystal structure of human frequenin (neuronal calcium sensor 1). J Biol Chem 276:11949-55 [Journal] [PubMed]

Boyett MR, Honjo H, Lei M, Kodama I (2001) Transient outward K+ current, ito, in the sinoatrial node Cardiovascular Res 52:519-520

Brahmajothi MV, Campbell DL (1999) Heterogeneous basal expression of nitric oxide synthase and superoxide dismutase isoforms in mammalian heart : implications for mechanisms governing indirect and direct nitric oxide-related effects. Circ Res 85:575-87 [PubMed]

Brahmajothi MV, Campbell DL, Rasmusson RL, Morales MJ, Trimmer JS, Nerbonne JM, Strauss HC (1999) Distinct transient outward potassium current (Ito) phenotypes and distribution of fast-inactivating potassium channel alpha subunits in ferret left ventricular myocytes. J Gen Physiol 113:581-600 [PubMed]

Brahmajothi MV, Morales MJ, Liu S, Rasmusson RL, Campbell DL, Strauss HC (1996) In situ hybridization reveals extensive diversity of K+ channel mRNA in isolated ferret cardiac myocytes. Circ Res 78:1083-9 [PubMed]

Brunet S, Aimond F, Li H, Guo W, Eldstrom J, Fedida D, Yamada KA, Nerbonne JM (2004) Heterogeneous expression of repolarizing, voltage-gated K+ currents in adult mouse ventricles. J Physiol 559:103-20 [Journal] [PubMed]

Brunner M, Guo W, Mitchell GF, Buckett PD, Nerbonne JM, Koren G (2001) Characterization of mice with a combined suppression of I(to) and I(K,slow). Am J Physiol Heart Circ Physiol 281:H1201-9 [Journal] [PubMed]

Campbell DL, Patel SP, Strauss HC (2002) Anomalous effects of varying K+ on inactivation and recovery kinetics of ferret left ventricular Ito. Biophys J 82:1186

Campbell DL, Qu Y, Rasmusson RL, Strauss HC (1993) The calcium-independent transient outward potassium current in isolated ferret right ventricular myocytes. II. Closed state reverse use-dependent block by 4-aminopyridine. J Gen Physiol 101:603-26 [PubMed]

Campbell DL, Rasmusson RL, Comer MB, Strauss HC (1995) The cardiaccalcium-independent transient outward potassium current: kinetics, molecular properties, androle in ventricular repolarization. Cardiac Electrophysiology. From Cell to Bedside (2nd edition), Zipes D:Jalife J, ed. pp.83

Campbell DL, Rasmusson RL, Qu Y, Strauss HC (1993) The calcium-independent transient outward potassium current in isolated ferret right ventricular myocytes. I. Basic characterization and kinetic analysis. J Gen Physiol 101:571-601 [PubMed]

Campbell DL, Rasmusson RL, Strauss HC (1992) Ionic current mechanisms generating vertebrate primary cardiac pacemaker activity at the single cell level: an integrative view. Annu Rev Physiol 54:279-302

Campbell DL, Stamler JS, Strauss HC (1996) Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols. J Gen Physiol 108:277-93 [PubMed]

Campomanes CR, Carroll KI, Manganas LN, Hershberger ME, Gong B, Antonucci DE, Rhodes KJ, Trimmer JS (2002) Kv beta subunit oxidoreductase activity and Kv1 potassium channel trafficking. J Biol Chem 277:8298-305 [Journal] [PubMed]

Carmeliet E, Vereecke J (2002) Ionic currents and action potentials in cardiac cells Cellular Cardiac Electrophysiology :95-117

Casis O, Iriarte M, Gallego M, Sánchez-Chapula JA (1998) Differences in regional distribution of K+ current densities in rat ventricle. Life Sci 63:391-400 [PubMed]

Castellino RC, Morales MJ, Strauss HC, Rasmusson RL (1995) Time- and voltage-dependent modulation of a Kv1.4 channel by a beta-subunit (Kv beta 3) cloned from ferret ventricle. Am J Physiol 269:H385-91 [Journal] [PubMed]

Cha A, Snyder GE, Selvin PR, Bezanilla F (1999) Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy. Nature 402:809-13

Chagot B, Escoubas P, Villegas E, Bernard C, Ferrat G, Corzo G, Lazdunski M, Darbon H (2004) Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus. Protein Sci 13:1197-208 [Journal] [PubMed]

Chang LS, Chen CY, Wu TT (2003) Functional implication with the metal-binding properties of KChIP1. Biochem Biophys Res Commun 311:258-63 [PubMed]

Chien KR (1999) Molecular Basis of Cardiovascular Disease

Choi KL, Aldrich RW, Yellen G (1991) Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channels. Proc Natl Acad Sci U S A 88:5092-5 [PubMed]

Clark RB, Bouchard RA, Salinas-Stefanon E, Sanchez-Chapula J, Giles WR (1993) Heterogeneity of action potential waveforms and potassium currents in rat ventricle. Cardiovasc Res 27:1795-9 [PubMed]

Clark RB, Giles WR, Imaizumi Y (1988) Properties of the transient outward current in rabbit atrial cells. J Physiol 405:147-68 [PubMed]

Comer MB, Campbell DL, Rasmusson RL, Lamson DR, Morales MJ, Zhang Y, Strauss HC (1994) Cloning and characterization of an Ito-like potassium channel from ferret ventricle. Am J Physiol 267:H1383-95 [Journal] [PubMed]

Craig TA, Benson LM, Venyaminov SY, Klimtchuk ES, Bajzer Z, Prendergast FG, Naylor S, Kumar R (2002) The metal-binding properties of DREAM: evidence for calcium-mediated changes in DREAM structure. J Biol Chem 277:10955-66 [Journal] [PubMed]

de Bakker JM, OptHof T (2002) Is the apico-basal gradient larger than the transmural gradient? J Cardiovasc Pharmacol 39:328-31 [PubMed]

Deal KK, England SK, Tamkun MM (1996) Molecular physiology of cardiac potassium channels. Physiol Rev 76:49-67 [Journal] [PubMed]

Decher N, Barth AS, Gonzalez T, Steinmeyer K, Sanguinetti MC (2004) Novel KChIP2 isoforms increase functional diversity of transient outward potassium currents. J Physiol 557:761-72 [Journal] [PubMed]

Decher N, Uyguner O, Scherer CR, Karaman B, Yuksel-Apak M, Busch AE, Steinmeyer K, Wollnik B (2001) hKChIP2 is a functional modifier of hKv4.3 potassium channels: cloning and expression of a short hKChIP2 splice variant. Cardiovasc Res 52:255-64

DECK KA, TRAUTWEIN W (1964) IONIC CURRENTS IN CARDIAC EXCITATION. Pflugers Arch Gesamte Physiol Menschen Tiere 280:63-80 [PubMed]

Demo SD, Yellen G (1991) The inactivation gate of the Shaker K+ channel behaves like an open-channel blocker. Neuron 7:743-53 [PubMed]

Deschênes I, DiSilvestre D, Juang GJ, Wu RC, An WF, Tomaselli GF (2002) Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)? Circulation 106:423-9 [PubMed]

Deschênes I, Tomaselli GF (2002) Modulation of Kv4.3 current by accessory subunits. FEBS Lett 528:183-8 [PubMed]

Diochot S, Drici MD, Moinier D, Fink M, Lazdunski M (1999) Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis. Br J Pharmacol 126:251-63 [Journal] [PubMed]

Dixon JE, McKinnon D (1994) Quantitative analysis of potassium channel mRNA expression in atrial and ventricular muscle of rats. Circ Res 75:252-60 [PubMed]

Dixon JE, Shi W, Wang HS, McDonald C, Yu H, Wymore RS, Cohen IS, McKinnon D (1996) Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current. Circ Res 79:659-68 [PubMed]

Doyle DA, Morais Cabral J, Pfuetzner RA, Kuo A, Gulbis JM, Cohen SL, Chait BT, MacKinnon R (1998) The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science 280:69-77 [PubMed]

Eghbali M, Olcese R, Zarei MM, Toro L, Stefani E (2002) External pore collapse as an inactivation mechanism for Kv4.3 K+ channels. J Membr Biol 188:73-86 [Journal] [PubMed]

Favre JF, Calmels TPG, Rouanet S, Javre JL, Cheval B, Bril A (1999) haracterization of Kv4.3 in HEK 293 cells: comparison with the rate ventricular transient outward potassium current Cardiovasc Res 41:188-199

Fedida D, Braun AP, Giles WR (1993) Alpha 1-adrenoceptors in myocardium: functional aspects and transmembrane signaling mechanisms. Physiol Rev 73:469-87 [Journal] [PubMed]

Fedida D, Giles WR (1991) Regional variations in action potentials and transient outward current in myocytes isolated from rabbit left ventricle. J Physiol 442:191-209 [PubMed]

Franqueza L, Valenzuela C, Eck J, Tamkun MM, Tamargo J, Snyders DJ (1999) Functional expression of an inactivating potassium channel (Kv4.3) in a mammalian cell line. Cardiovasc Res 41:212-9 [PubMed]

Gandhi CS, Isacoff EY (2002) Molecular models of voltage sensing. J Gen Physiol 120:455-63 [PubMed]

Gebauer M, Isbrandt D, Sauter K, Callsen B, Nolting A, Pongs O, Bähring R (2004) N-type inactivation features of Kv4.2 channel gating. Biophys J 86:210-23 [Journal] [PubMed]

Giles WR, Imaizumi Y (1988) Comparison of potassium currents in rabbit atrial and ventricular cells. J Physiol 405:123-45 [PubMed]

Glauner KS, Mannuzzu LM, Gandhi CS, Isacoff EY (1999) Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel. Nature 402:813-7 [Journal] [PubMed]

Greenstein JL, Wu R, Po S, Tomaselli GF, Winslow RL (2000) Role of the calcium-independent transient outward current I(to1) in shaping action potential morphology and duration. Circ Res 87:1026-33 [PubMed]

   Kv4.3, Kv1.4 encoded K(+) channel in heart cells (Greenstein et al 2000) (XPP) [Model]
   Kv4.3, Kv1.4 encoded K channel in heart cells & tachy. (Winslow et al 1999, Greenstein et al 2000) [Model]

Gulbis JM, Mann S, MacKinnon R (1999) Structure of a voltage-dependent K+ channel beta subunit. Cell 97:943-52 [PubMed]

Guo W, Li H, Aimond F, Johns DC, Rhodes KJ, Trimmer JS, Nerbonne JM (2002) Role of heteromultimers in the generation of myocardial transient outward K+ currents. Circ Res 90:586-93 [PubMed]

Guo W, Li H, London B, Nerbonne JM (2000) Functional consequences of elimination of i(to,f) and i(to,s): early afterdepolarizations, atrioventricular block, and ventricular arrhythmias in mice lacking Kv1.4 and expressing a dominant-negative Kv4 alpha subunit. Circ Res 87:73-9 [PubMed]

Guo W, Malin SA, Johns DC, Jeromin A, Nerbonne JM (2002) Modulation of Kv4-encoded K(+) currents in the mammalian myocardium by neuronal calcium sensor-1. J Biol Chem 277:26436-43 [Journal] [PubMed]

Guo W, Xu H, London B, Nerbonne JM (1999) Molecular basis of transient outward K+ current diversity in mouse ventricular myocytes. J Physiol 521 Pt 3:587-99 [PubMed]

Gussack I, Antzelevitch C (2003) Cardiac Repolarization

Han W, Bao W, Wang Z, Nattel S (2002) Comparison of ion-channel subunit expression in canine cardiac Purkinje fibers and ventricular muscle. Circ Res 91:790-7 [PubMed]

Han W, Wang Z, Nattel S (2000) A comparison of transient outward currents in canine cardiac Purkinje cells and ventricular myocytes. Am J Physiol Heart Circ Physiol 279:H466-74 [Journal] [PubMed]

Han W, Zhang L, Schram G, Nattel S (2002) Properties of potassium currents in Purkinje cells of failing human hearts. Am J Physiol Heart Circ Physiol 283:H2495-503 [Journal] [PubMed]

Hatano N, Ohya S, Muraki K, Clark RB, Giles WR, Imaizumi Y (2004) Two arginines in the cytoplasmic C-terminal domain are essential for voltage-dependent regulation of A-type K+ current in the Kv4 channel subfamily. J Biol Chem 279:5450-9 [Journal] [PubMed]

Heginbotham L, Lu Z, Abramson T, MacKinnon R (1994) Mutations in the K+ channel signature sequence. Biophys J 66:1061-7 [Journal] [PubMed]

Hille B (2001) Classic mechanisms of block Ion Channels of Excitable Membranes (3rd edn) :503-537

HODGKIN AL, HUXLEY AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117:500-44 [Journal] [PubMed]

   Squid axon (Hodgkin, Huxley 1952) (LabAXON) [Model]
   Squid axon (Hodgkin, Huxley 1952) (NEURON) [Model]
   Squid axon (Hodgkin, Huxley 1952) (SNNAP) [Model]
   Squid axon (Hodgkin, Huxley 1952) used in (Chen et al 2010) (R language) [Model]
   Squid axon (Hodgkin, Huxley 1952) (SBML, XPP, other) [Model]

Holmqvist MH, Cao J, Hernandez-Pineda R, Jacobson MD, Carroll KI, Sung MA, Betty M, Ge P, Gilbride KJ, Brown ME, Jurman ME, Lawson D, Silos-Santiago I, Xie Y, Covarrubias M, Rhodes KJ, Distefano PS, An WF (2002) Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain. Proc Natl Acad Sci U S A 99:1035-40 [Journal] [PubMed]

Holmqvist MH, Cao J, Knoppers MH, Jurman ME, Distefano PS, Rhodes KJ, Xie Y, An WF (2001) Kinetic modulation of Kv4-mediated A-current by arachidonic acid is dependent on potassium channel interacting proteins. J Neurosci 21:4154-61 [PubMed]

Hoshi T, Zagotta WN, Aldrich RW (1990) Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 250:533-8 [PubMed]

Hoshi T, Zagotta WN, Aldrich RW (1991) Two types of inactivation in Shaker K+ channels: effects of alterations in the carboxy-terminal region. Neuron 7:547-56 [PubMed]

Huelsing DJ, Spitzer KW, Pollard AE (2003) Spontaneous activity induced in rabbit Purkinje myocytes during coupling to a depolarized model cell. Cardiovasc Res 59:620-7 [PubMed]

Iyer V, Mazhari R, Winslow RL (2004) A computational model of the human left-ventricular epicardial myocyte. Biophys J 87:1507-25 [Journal] [PubMed]

Jerng HH, Covarrubias M (1997) K+ channel inactivation mediated by the concerted action of the cytoplasmic N- and C-terminal domains. Biophys J 72:163-74 [Journal] [PubMed]

Jerng HH, Qian Y, Pfaffinger PJ (2004) Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). Biophys J 87:2380-96 [Journal] [PubMed]

Jerng HH, Shahidullah M, Covarrubias M (1999) Inactivation gating of Kv4 potassium channels: molecular interactions involving the inner vestibule of the pore. J Gen Physiol 113:641-60 [PubMed]

Jiang X, Bett GC, Li X, Bondarenko VE, Rasmusson RL (2003) C-type inactivation involves a significant decrease in the intracellular aqueous pore volume of Kv1.4 K+ channels expressed in Xenopus oocytes. J Physiol 549:683-95 [Journal] [PubMed]

Jiang Y, Lee A, Chen J, Ruta V, Cadene M, Chait BT, MacKinnon R (2003) X-ray structure of a voltage-dependent K+ channel. Nature 423:33-41 [Journal] [PubMed]

Kääb S, Dixon J, Duc J, Ashen D, Näbauer M, Beuckelmann DJ, Steinbeck G, McKinnon D, Tomaselli GF (1998) Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density. Circulation 98:1383-93 [PubMed]

Kim LA, Furst J, Butler MH, Xu S, Grigorieff N, Goldstein SA (2003) Composition of Ito channels: Kv4.2-KChIP2 complexes carry four subunits of each type J Biol Chem 279:5549-5554

Kim LA, Furst J, Gutierrez D, Butler MH, Xu S, Goldstein SA, Grigorieff N (2004) Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution. Neuron 41:513-9

Kuo HC, Cheng CF, Clark RB, Lin JJ, Lin JL, Hoshijima M, Nguyen-Tran VT, Gu Y, Ikeda Y, Chu P (2001) A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia. Cell 107:801-13

Kuryshev YA, Gudz TI, Brown AM, Wible BA (2000) KChAP as a chaperone for specific K(+) channels. Am J Physiol Cell Physiol 278:C931-41 [Journal] [PubMed]

Lainé M, Lin MC, Bannister JP, Silverman WR, Mock AF, Roux B, Papazian DM (2003) Atomic proximity between S4 segment and pore domain in Shaker potassium channels. Neuron 39:467-81 [PubMed]

Lainé M, Papazian DM, Roux B (2004) Critical assessment of a proposed model of Shaker. FEBS Lett 564:257-63 [Journal] [PubMed]

Larsson HP, Baker OS, Dhillon DS, Isacoff EY (1996) Transmembrane movement of the shaker K+ channel S4. Neuron 16:387-97 [PubMed]

Lee SY, MacKinnon R (2004) A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. Nature 430:232-5 [Journal] [PubMed]

Li X, Bett GC, Jiang X, Bondarenko VE, Morales MJ, Rasmusson RL (2003) Regulation of N- and C-type inactivation of Kv1.4 by pHo and K+: evidence for transmembrane communication. Am J Physiol Heart Circ Physiol 284:H71-80 [Journal] [PubMed]

Libbus I, Wan X, Rosenbaum DS (2004) Electrotonic load triggers remodeling of repolarizing current Ito in ventricle. Am J Physiol Heart Circ Physiol 286:H1901-9 [Journal] [PubMed]

Linse S, Forsn S (1995) Determinants that govern high-affinity calcium binding Calcium Regulation of Cellular Function, Means AR, ed. pp.89

Liu DW, Gintant GA, Antzelevitch C (1993) Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle. Circ Res 72:671-87 [PubMed]

London B (2001) Cardiac arrhythmias: from (transgenic) mice to men. J Cardiovasc Electrophysiol 12:1089-91 [PubMed]

London B, Wang DW, Hill JA, Bennett PB (1998) The transient outward current in mice lacking the potassium channel gene Kv1.4. J Physiol 509 ( Pt 1):171-82 [PubMed]

MacKinnon R (2003) Potassium channels. FEBS Lett 555:62-5 [PubMed]

Mannuzzu LM, Moronne MM, Isacoff EY (1996) Direct physical measure of conformational rearrangement underlying potassium channel gating. Science 271:213-6 [PubMed]

McCormack T, McCormack K (1994) Shaker K+ channel beta subunits belong to an NAD(P)H-dependent oxidoreductase superfamily. Cell 79:1133-5 [PubMed]

McKinnon D (1999) Molecular identity of Ito: Kv1.4 redux. Circ Res 84:620-2 [PubMed]

Morales MJ, Castellino RC, Crews AL, Rasmusson RL, Strauss HC (1995) A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits. J Biol Chem 270:6272-7 [PubMed]

Näbauer M, Beuckelmann DJ, Uberfuhr P, Steinbeck G (1996) Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation 93:168-77 [PubMed]

Nadal MS, Amarillo Y, Vega-Saenz de Miera E, Rudy B (2001) Evidence for the presence of a novel Kv4-mediated A-type K(+) channel-modifying factor. J Physiol 537:801-9 [PubMed]

Nakamura TY, Pountney DJ, Ozaita A, Nandi S, Ueda S, Rudy B, Coetzee WA (2001) A role for frequenin, a Ca2+-binding protein, as a regulator of Kv4 K+-currents. Proc Natl Acad Sci U S A 98:12808-13 [Journal] [PubMed]

Nef P (1996) Neuron specific calcium sensors (the NCS subfamily) Guidebook to the Calcium-Binding Proteins, Celio MR:Pauls T:Schwaller B, ed. pp.94

Nerbonne JM (2000) Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium. J Physiol 525 Pt 2:285-98 [PubMed]

Nerbonne JM (2002) Molecular analysis of voltage-gated K+ channel diversity and functioning in the mammalian heart Handbook of Physiology, Page E:Fozzard HA:Solaro RJ, ed. pp.568

Nerbonne JM (2004) Studying cardiac arrhythmias in the mouse--a reasonable model for probing mechanisms? Trends Cardiovasc Med 14:83-93 [Journal] [PubMed]

Nerbonne JM, Kass RS (2003) Physiology and molecular biology of ion channels contributing to ventricular repolarization Cardiac Repolarization, Gussack I:Antzelevitch C, ed. pp.25

Ohya S, Morohashi Y, Muraki K, Tomita T, Watanabe M, Iwatsubo T, Imaizumi Y (2001) Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2. Biochem Biophys Res Commun 282:96-102 [Journal] [PubMed]

Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH (2001) The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium. J Mol Cell Cardiol 33:851-72 [Journal] [PubMed]

Patel SP, Campbell DL, Morales MJ, Strauss HC (2002) Heterogeneous expression of KChIP2 isoforms in the ferret heart. J Physiol 539:649-56 [PubMed]

Patel SP, Campbell DL, Strauss HC (2002) Elucidating KChIP effects on Kv4.3 inactivation and recovery kinetics with a minimal KChIP2 isoform. J Physiol 545:5-11 [PubMed]

Patel SP, Parai R, Parai R, Campbell DL (2004) Regulation of Kv4.3 voltage-dependent gating kinetics by KChIP2 isoforms. J Physiol 557:19-41 [Journal] [PubMed]

Patlak J (1991) Molecular kinetics of voltage-dependent Na+ channels. Physiol Rev 71:1047-80 [Journal] [PubMed]

Pérez-García MT, López-López JR, González C (1999) Kvbeta1.2 subunit coexpression in HEK293 cells confers O2 sensitivity to kv4.2 but not to Shaker channels. J Gen Physiol 113:897-907 [PubMed]

Petersen KR, Nerbonne JM (1999) Expression environment determines K+ current properties: Kv1 and Kv4 alpha-subunit-induced K+ currents in mammalian cell lines and cardiac myocytes. Pflugers Arch 437:381-92 [PubMed]

Po S, Snyders DJ, Baker R, Tamkun MM, Bennett PB (1992) Functional expression of an inactivating potassium channel cloned from human heart. Circ Res 71:732-6 [PubMed]

Pourrier M, Herrera D, Caballero R, Schram G, Wang Z, Nattel S (2004) The Kv4.2 N-terminal restores fast inactivation and confers KChlP2 modulatory effects on N-terminal-deleted Kv1.4 channels. Pflugers Arch 449:235-47 [Journal] [PubMed]

Puglisi JL, Bers DM (2001) LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport. Am J Physiol Cell Physiol 281:C2049-60 [Journal] [PubMed]

   A cardiac cell simulator (Puglisi and Bers 2001), applied to the QT interval (Busjahn et al 2004) [Model]

Puglisi JL, Wang F, Bers DM (2005) Modeling the isolated cardiac myocyte. Prog Biophys Mol Biol 85:163-78

Rasmusson RL, Morales MJ, Castellino RC, Zhang Y, Campbell DL, Strauss HC (1995) C-type inactivation controls recovery in a fast inactivating cardiac K+ channel (Kv1.4) expressed in Xenopus oocytes. J Physiol 489 ( Pt 3):709-21 [PubMed]

Rasmusson RL, Morales MJ, Wang S, Liu S, Campbell DL, Brahmajothi MV, Strauss HC (1998) Inactivation of voltage-gated cardiac K+ channels. Circ Res 82:739-50 [PubMed]

Rasmusson RL, Zhang Y, Campbell DL, Comer MB, Castellino RC, Liu S, Strauss HC (1995) Bi-stable block by 4-aminopyridine of a transient K+ channel (Kv1.4) cloned from ferret ventricle and expressed in Xenopus oocytes. J Physiol 485 ( Pt 1):59-71 [PubMed]

Ren X, Shand SH, Takimoto K (2003) Effective association of Kv channel-interacting proteins with Kv4 channel is mediated with their unique core peptide. J Biol Chem 278:43564-70 [Journal] [PubMed]

Robertson B (2001) Pharmacology of voltage-gated K+ channels Potassium Channels in Cardiovascular Biology, Archer SL:Rusch SJ, ed. pp.195

Roeper J, Lorra C, Pongs O (1997) Frequency-dependent inactivation of mammalian A-type K+ channel KV1.4 regulated by Ca2+/calmodulin-dependent protein kinase. J Neurosci 17:3379-91 [PubMed]

Rosati B, Grau F, Rodriguez S, Li H, Nerbonne JM, McKinnon D (2003) Concordant expression of KChIP2 mRNA, protein and transient outward current throughout the canine ventricle. J Physiol 548:815-22 [Journal] [PubMed]

Rosati B, Pan Z, Lypen S, Wang HS, Cohen I, Dixon JE, McKinnon D (2001) Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. J Physiol 533:119-25 [PubMed]

Rudy Y (2002) The cardiac ventricular action potential Handbook of Physiology, Page E:Fozzard HA:Solaro RJ, ed. pp.531

Ruppersberg JP, Frank R, Pongs O, Stocker M (1991) Cloned neuronal IK(A) channels reopen during recovery from inactivation. Nature 353:657-60 [Journal] [PubMed]

Ruppersberg JP, Stocker M, Pongs O, Heinemann SH, Frank R, Koenen M (1991) Regulation of fast inactivation of cloned mammalian IK(A) channels by cysteine oxidation. Nature 352:711-4 [Journal] [PubMed]

Sah R, Ramirez RJ, Oudit GY, Gidrewicz D, Trivieri MG, Zobel C, Backx PH (2003) Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to)). J Physiol 546:5-18 [PubMed]

Sanguinetti MC, Bennett PB (2003) Antiarrhythmic drug target choices and screening. Circ Res 93:491-9 [Journal] [PubMed]

Sanguinetti MC, Johnson JH, Hammerland LG, Kelbaugh PR, Volkmann RA, Saccomano NA, Mueller AL (1997) Heteropodatoxins: peptides isolated from spider venom that block Kv4.2 potassium channels. Mol Pharmacol 51:491-8 [PubMed]

Scannevin RH, Wang K, Jow F, Megules J, Kopsco DC, Edris W, Carroll KC, Lü Q, Xu W, Xu Z, Katz AH, Olland S, Lin L, Taylor M, Stahl M, Malakian K, Somers W, Mosyak L, Bowlby MR, Chanda P, Rhodes KJ (2004) Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1. Neuron 41:587-98 [PubMed]

Schönherr R, Mannuzzu LM, Isacoff EY, Heinemann SH (2002) Conformational switch between slow and fast gating modes: allosteric regulation of voltage sensor mobility in the EAG K+ channel. Neuron 35:935-49 [PubMed]

Schrader LA, Anderson AE, Mayne A, Pfaffinger PJ, Sweatt JD (2002) PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex. J Neurosci 22:10123-33 [PubMed]

Serôdio P, Vega-Saenz de Miera E, Rudy B (1996) Cloning of a novel component of A-type K+ channels operating at subthreshold potentials with unique expression in heart and brain. J Neurophysiol 75:2174-9 [Journal] [PubMed]

Shahidullah M, Covarrubias M (2003) The link between ion permeation and inactivation gating of Kv4 potassium channels. Biophys J 84:928-41 [Journal] [PubMed]

Shiau YS, Huang PT, Liou HH, Liaw YC, Shiau YY, Lou KL (2003) Structural basis of binding and inhibition of novel tarantula toxins in mammalian voltage-dependent potassium channels. Chem Res Toxicol 16:1217-25 [Journal] [PubMed]

Shimoni Y, Severson D, Giles W (1995) Thyroid status and diabetes modulate regional differences in potassium currents in rat ventricle. J Physiol 488 ( Pt 3):673-88

Sokolova O (2004) Structure of cation channels, revealed by single particle electron microscopy. FEBS Lett 564:251-6 [Journal] [PubMed]

Sokolova O, Kolmakova-Partensky L, Grigorieff N (2001) Three-dimensional structure of a voltage-gated potassium channel at 2.5 nm resolution. Structure 9:215-20 [PubMed]

Starace DM, Bezanilla F (2001) Histidine scanning mutagenesis of basic residues of the S4 segment of the shaker k+ channel. J Gen Physiol 117:469-90 [PubMed]

Starace DM, Bezanilla F (2004) A proton pore in a potassium channel voltage sensor reveals a focused electric field. Nature 427:548-53 [Journal] [PubMed]

Starace DM, Stefani E, Bezanilla F (1997) Voltage-dependent proton transport by the voltage sensor of the Shaker K+ channel. Neuron 19:1319-27 [PubMed]

Strauss HC, Morales MJ, Wang S, Brahmajothi MV, Campbell DL (2001) Voltage dependent K+ channels Heart Physiology and Pathophysiology (4th edition), Sperelakis N:Kurachi Y:Terzic A:Cohen MV, ed. pp.259

Strauss HC, Rasmusson RL (2002) Restitution, ventricular fibrillation, and drugs: where are we now? J Cardiovasc Electrophysiol 13:915-7 [PubMed]

Swartz KJ, MacKinnon R (1997) Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels. Neuron 18:675-82 [PubMed]

Taggart P, Sutton P, Opthof T, Coronel R, Kallis P (2005) Electrotonic cancellation of transmural electrical gradients in the left ventricle in man. Prog Biophys Mol Biol 82:243-54

Tamkun MM, Knoth KM, Walbridge JA, Kroemer H, Roden DM, Glover DM (1991) Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle. FASEB J 5:331-7 [PubMed]

Tombola F, Pathak MM, Isacoff EY (2005) Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective pores. Neuron 45:379-88

Tseng GN, Jiang M, Yao JA (1996) Reverse use dependence of Kv4.2 blockade by 4-aminopyridine. J Pharmacol Exp Ther 279:865-76 [PubMed]

Tseng-Crank JC, Tseng GN, Schwartz A, Tanouye MA (1990) Molecular cloning and functional expression of a potassium channel cDNA isolated from a rat cardiac library. FEBS Lett 268:63-8 [PubMed]

Van_Wagoner DR, Nerbonne JM (2001) Molecular mechanisms of atrial fibrillation Heart Physiology and Pathophysiology (4th edn), SPerelakis N:Kurachi Y:Terzic A:Cohen MV, ed. pp.1107

Varro A, Lathrop DA, Hester SB, Nanasi PP, Papp JG (2006) Ionic currents and action potentials in rabbit, rat, and guinea pig ventricular myocytes. Basic Res Cardiol 88:93-102

Verkerk AO, van Ginneken AC (2001) Considerations in studying the transient outward K(+) current in cells exhibiting the hyperpolarization-activated current. Cardiovasc Res 52:517-20 [PubMed]

Wada K, Yokotani N, Hunter C, Doi K, Wenthold RJ, Shimasaki S (1992) Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family. Proc Natl Acad Sci U S A 89:197-201 [PubMed]

Wang S, Bondarenko VE, Qu Y, Morales MJ, Rasmusson RL, Strauss HC (2004) Activation properties of Kv4.3 channels: time, voltage and [K+]o dependence. J Physiol 557:705-17 [Journal] [PubMed]

Wang S, Patel SP, Qu Y, Hua P, Strauss HC, Morales MJ (2002) Kinetic properties of Kv4.3 and their modulation by KChIP2b. Biochem Biophys Res Commun 295:223-9 [PubMed]

Wible BA, Yang Q, Kuryshev YA, Accili EA, Brown AM (1998) Cloning and expression of a novel K+ channel regulatory protein, KChAP. J Biol Chem 273:11745-51 [PubMed]

Wickenden AD, Lee P, Sah R, Huang Q, Fishman GI, Backx PH (1999) Targeted expression of a dominant-negative K(v)4.2 K(+) channel subunit in the mouse heart. Circ Res 85:1067-76 [PubMed]

Winslow RL, Cortassa S, Greenstein JL (2005) Using models of the myocyte for functional interpretation of cardiac proteomic data. J Physiol 563:73-81 [Journal] [PubMed]

Winslow RL, Scollan DF, Holmes A, Yung CK, Zhang J, Jafri MS (2000) Electrophysiological modeling of cardiac ventricular function: from cell to organ. Annu Rev Biomed Eng 2:119-55

Wissmann R, Bildl W, Oliver D, Beyermann M, Kalbitzer HR, Bentrop D, Fakler B (2003) Solution structure and function of the "tandem inactivation domain" of the neuronal A-type potassium channel Kv1.4. J Biol Chem 278:16142-50 [Journal] [PubMed]

Xu H, Guo W, Nerbonne JM (1999) Four kinetically distinct depolarization-activated K+ currents in adult mouse ventricular myocytes. J Gen Physiol 113:661-78 [PubMed]

Yang EK, Alvira MR, Levitan ES, Takimoto K (2001) Kvbeta subunits increase expression of Kv4.3 channels by interacting with their C termini. J Biol Chem 276:4839-44 [Journal] [PubMed]

Yellen G (1998) The moving parts of voltage-gated ion channels. Q Rev Biophys 31:239-95 [PubMed]

Yellen G (2002) The voltage-gated potassium channels and their relatives. Nature 419:35-42 [Journal] [PubMed]

Yeola SW, Snyders DJ (1997) Electrophysiological and pharmacological correspondence between Kv4.2 current and rat cardiac transient outward current. Cardiovasc Res 33:540-7 [PubMed]

Zagotta WN, Hoshi T, Aldrich RW (1990) Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB. Science 250:568-71 [PubMed]

Zhang M, Jiang M, Tseng GN (2001) minK-related peptide 1 associates with Kv4.2 and modulates its gating function: potential role as beta subunit of cardiac transient outward channel? Circ Res 88:1012-9 [PubMed]

Zhou W, Qian Y, Kunjilwar K, Pfaffinger PJ, Choe S (2004) Structural insights into the functional interaction of KChIP1 with Shal-type K(+) channels. Neuron 41:573-86 [PubMed]

Zicha S, Moss I, Allen B, Varro A, Papp J, Dumaine R, Antzelevich C, Nattel S (2003) Molecular basis of species-specific expression of repolarizing K+ currents in the heart. Am J Physiol Heart Circ Physiol 285:H1641-9 [Journal] [PubMed]

Flaim SN, Giles WR, McCulloch AD (2006) Contributions of sustained INa and IKv43 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytes. Am J Physiol Heart Circ Physiol 291:H2617-29 [Journal] [PubMed]

   INa and IKv4.3 heterogeneity in canine LV myocytes (Flaim et al 2006) [Model]

Wang S, Bondarenko VE, Qu YJ, Bett GC, Morales MJ, Rasmusson RL, Strauss HC (2005) Time- and voltage-dependent components of Kv4.3 inactivation. Biophys J 89:3026-41 [Journal] [PubMed]

(189 refs)