Citation Relationships

Wang YJ, Chen BS, Lin MW, Lin AA, Peng H, Sung RJ, Wu SN (2008) Time-dependent block of ultrarapid-delayed rectifier K+ currents by aconitine, a potent cardiotoxin, in heart-derived H9c2 myoblasts and in neonatal rat ventricular myocytes. Toxicol Sci 106:454-63 [PubMed]

   Action potential of adult rat ventricle (Wang et al. 2008)

References and models cited by this paper

References and models that cite this paper

Aimond F, Kwak SP, Rhodes KJ, Nerbonne JM (2005) Accessory Kvbeta1 subunits differentially modulate the functional expression of voltage-gated K+ channels in mouse ventricular myocytes. Circ Res 96:451-8 [Journal] [PubMed]

Bondarenko VE, Szigeti GP, Bett GC, Kim SJ, Rasmusson RL (2004) Computer model of action potential of mouse ventricular myocytes. Am J Physiol Heart Circ Physiol 287:H1378-403 [Journal] [PubMed]

Chodoeva A, Bosc JJ, Guillon J, Decendit A, Petraud M, Absalon C, Vitry C, Jarry C, Robert J (2005) 8-O-Azeloyl-14-benzoylaconine: a new alkaloid from the roots of Aconitum karacolicum Rapcs and its antiproliferative activities. Bioorg Med Chem 13:6493-501 [Journal] [PubMed]

Dasyukevich OI, Solyanik GI (2007) Comparative study of anticancer efficacy of aonitine-containing agent BC1 against ascite and solid forms of Ehrlich's carcinoma. Exp Oncol 29:317-9 [PubMed]

Fraser SP, Salvador V, Manning EA, Mizal J, Altun S, Raza M, Berridge RJ, Djamgoz MB (2003) Contribution of functional voltage-gated Na+ channel expression to cell behaviors involved in the metastatic cascade in rat prostate cancer: I. Lateral motility. J Cell Physiol 195:479-87 [Journal] [PubMed]

Fu M, Wu M, Wang JF, Qiao YJ, Wang Z (2007) Disruption of the intracellular Ca2+ homeostasis in the cardiac excitation-contraction coupling is a crucial mechanism of arrhythmic toxicity in aconitine-induced cardiomyocytes. Biochem Biophys Res Commun 354:929-36 [Journal] [PubMed]

Huang CW, Huang CC, Cheng JT, Tsai JJ, Wu SN (2007) Glucose and hippocampal neuronal excitability: role of ATP-sensitive potassium channels. J Neurosci Res 85:1468-77 [Journal] [PubMed]

   The role of ATP-sensitive potassium channels in a hippocampal neuron (Huang et al. 2007) [Model]

Ju M, Stevens L, Leadbitter E, Wray D (2003) The Roles of N- and C-terminal determinants in the activation of the Kv2.1 potassium channel. J Biol Chem 278:12769-78 [Journal] [PubMed]

Kunze DL, Lacerda AE, Wilson DL, Brown AM (1985) Cardiac Na currents and the inactivating, reopening, and waiting properties of single cardiac Na channels. J Gen Physiol 86:691-719 [PubMed]

Lin MW, Wang YJ, Liu SI, Lin AA, Lo YC, Wu SN (2008) Characterization of aconitine-induced block of delayed rectifier K+ current in differentiated NG108-15 neuronal cells. Neuropharmacology 54:912-23 [Journal] [PubMed]

   Properties of aconitine-induced block of KDR current in NG108-15 neurons (Lin et al. 2008) [Model]

Lo YC, Yang SR, Huang MH, Liu YC, Wu SN (2005) Characterization of chromanol 293B-induced block of the delayed-rectifier K+ current in heart-derived H9c2 cells. Life Sci 76:2275-86 [Journal] [PubMed]

Lo YK, Wu SN, Lee CT, Li HF, Chiang HT (2001) Characterization of action potential waveform-evoked L-type calcium currents in pituitary GH3 cells. Pflugers Arch 442:547-57 [PubMed]

Ménard C, Pupier S, Mornet D, Kitzmann M, Nargeot J, Lory P (1999) Modulation of L-type calcium channel expression during retinoic acid-induced differentiation of H9C2 cardiac cells. J Biol Chem 274:29063-70 [PubMed]

Misonou H, Mohapatra DP, Park EW, Leung V, Zhen D, Misonou K, Anderson AE, Trimmer JS (2004) Regulation of ion channel localization and phosphorylation by neuronal activity. Nat Neurosci 7:711-8 [Journal] [PubMed]

Moudgil R, Michelakis ED, Archer SL (2006) The role of k+ channels in determining pulmonary vascular tone, oxygen sensing, cell proliferation, and apoptosis: implications in hypoxic pulmonary vasoconstriction and pulmonary arterial hypertension. Microcirculation 13:615-32 [Journal] [PubMed]

Murakoshi H, Trimmer JS (1999) Identification of the Kv2.1 K+ channel as a major component of the delayed rectifier K+ current in rat hippocampal neurons. J Neurosci 19:1728-35 [PubMed]

Ordög B, Brutyó E, Puskás LG, Papp JG, Varró A, Szabad J, Boldogkoi Z (2006) Gene expression profiling of human cardiac potassium and sodium channels. Int J Cardiol 111:386-93 [Journal] [PubMed]

Park KS, Mohapatra DP, Misonou H, Trimmer JS (2006) Graded regulation of the Kv2.1 potassium channel by variable phosphorylation. Science 313:976-9 [Journal] [PubMed]

Ranki HJ, Budas GR, Crawford RM, Davies AM, Jovanovic A (2002) 17Beta-estradiol regulates expression of K(ATP) channels in heart-derived H9c2 cells. J Am Coll Cardiol 40:367-74 [PubMed]

Sah R, Ramirez RJ, Oudit GY, Gidrewicz D, Trivieri MG, Zobel C, Backx PH (2003) Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to)). J Physiol 546:5-18 [PubMed]

Sawanobori T, Hirano Y, Hiraoka M (1987) Aconitine-induced delayed afterdepolarization in frog atrium and guinea pig papillary muscles in the presence of low concentrations of Ca2+. Jpn J Physiol 37:59-79 [PubMed]

Solyanik GI, Fedorchuk AG, Pyaskovskaya ON, Dasyukevitch OI, Khranovskaya NN, Aksenov GN, Sobetsky VV (2004) Anticancer activity of aconitine-containing herbal extract BC1. Exp Oncol 26:307-11 [PubMed]

Suzuki T, Takimoto K (2004) Selective expression of HERG and Kv2 channels influences proliferation of uterine cancer cells. Int J Oncol 25:153-9 [PubMed]

Wang SY, Wang GK (2003) Voltage-gated sodium channels as primary targets of diverse lipid-soluble neurotoxins. Cell Signal 15:151-9 [PubMed]

Wang W, Hino N, Yamasaki H, Aoki T, Ochi R (2002) KV2.1 K+ channels underlie major voltage-gated K+ outward current in H9c2 myoblasts. Jpn J Physiol 52:507-14 [PubMed]

Wang Y, Cheng J, Tandan S, Jiang M, McCloskey DT, Hill JA (2006) Transient-outward K+ channel inhibition facilitates L-type Ca2+ current in heart. J Cardiovasc Electrophysiol 17:298-304 [Journal] [PubMed]

Wang YJ, Liu YC, Chang HD, Wu SN (2006) Diosgenin, a plant-derived sapogenin, stimulates Ca2+-activated K+ current in human cortical HCN-1A neuronal cells. Planta Med 72:430-6 [Journal] [PubMed]

Wang YJ, Sung RJ, Lin MW, Wu SN (2006) Contribution of BK(Ca)-channel activity in human cardiac fibroblasts to electrical coupling of cardiomyocytes-fibroblasts. J Membr Biol 213:175-85 [Journal] [PubMed]

   Ventricular cell model (Luo Rudy dynamic model) (Luo Rudy 1994) used in (Wang et al 2006) (XPP) [Model]
   Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Wright SN (2002) Comparison of aconitine-modified human heart (hH1) and rat skeletal (mu1) muscle Na+ channels: an important role for external Na+ ions. J Physiol 538:759-71 [PubMed]

Wu SN, Chang HD (2006) Diethyl pyrocarbonate, a histidine-modifying agent, directly stimulates activity of ATP-sensitive potassium channels in pituitary GH(3) cells. Biochem Pharmacol 71:615-23 [Journal] [PubMed]

   A model for pituitary GH(3) lactotroph (Wu and Chang 2005) [Model]

Wu SN, Chang HD, Sung RJ (2006) Cocaine-induced inhibition of ATP-sensitive K+ channels in rat ventricular myocytes and in heart-derived H9c2 cells. Basic Clin Pharmacol Toxicol 98:510-7 [Journal] [PubMed]

Wu SN, Wang YJ, Lin MW (2007) Potent stimulation of large-conductance Ca2+-activated K+ channels by rottlerin, an inhibitor of protein kinase C-delta, in pituitary tumor (GH3) cells and in cortical neuronal (HCN-1A) cells. J Cell Physiol 210:655-66 [Journal] [PubMed]

Xiao K, Wang L, Liu Y, Peng C, Yan G, Zhang J, Zhuo Y, Li H (2007) Study of aconitine toxicity in rat embryos in vitro. Birth Defects Res B Dev Reprod Toxicol 80:208-12 [Journal] [PubMed]

Xu H, Barry DM, Li H, Brunet S, Guo W, Nerbonne JM (1999) Attenuation of the slow component of delayed rectification, action potential prolongation, and triggered activity in mice expressing a dominant-negative Kv2 alpha subunit. Circ Res 85:623-33 [PubMed]

Yan ZC, Chen D, Wu XZ, Xie GR, Ba Y, Yan Z (2007) Effects of aqueous extracts of Aconitum carmichaeli, Rhizoma bolbostemmatis, Phytolacca acinosa, Panax notoginseng and Gekko swinhonis Guenther on Bel-7402 cells. World J Gastroenterol 13:2743-6 [PubMed]

Zhou J, Jeron A, London B, Han X, Koren G (1998) Characterization of a slowly inactivating outward current in adult mouse ventricular myocytes. Circ Res 83:806-14 [PubMed]

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