From Zhu and Clancy: "... Here we
employ theoretical simulations to examine the effects of a Timothy Syndrome (TS) mutation
in the L-type Ca2+ channel on cardiac dynamics over multiple
scales, from a gene mutation to protein, cell, tissue, and finally the
ECG, to connect a defective Ca2+ channel to arrhythmia susceptibility. ..."
Fox JJ, McHarg JL, Gilmour RF (2002) Ionic mechanism of electrical alternans. Am J Physiol Heart Circ Physiol 282:H516-30 [PubMed]
Zhu ZI, Clancy CE (2007) L-type Ca2+ channel mutations and T-wave alternans: a model study. Am J Physiol Heart Circ Physiol 293:H3480-9 [PubMed]