Excitation-contraction coupling/mitochondrial energetics (ECME) model (Cortassa et al. 2006)

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"An intricate network of reactions is involved in matching energy supply with demand in the heart. This complexity arises because energy production both modulates and is modulated by the electrophysiological and contractile activity of the cardiac myocyte. Here, we present an integrated mathematical model of the cardiac cell that links excitation-contraction coupling with mitochondrial energy generation. The dynamics of the model are described by a system of 50 ordinary differential equations. The formulation explicitly incorporates cytoplasmic ATP-consuming processes associated with force generation and ion transport, as well as the creatine kinase reaction. Changes in the electrical and contractile activity of the myocyte are coupled to mitochondrial energetics through the ATP, Ca21, and Na1 concentrations in the myoplasmic and mitochondrial matrix compartments. ..."
1 . Cortassa S, Aon MA, Marbán E, Winslow RL, O'Rourke B (2003) An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys J 84:2734-55 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Electrogenic pump;
Brain Region(s)/Organism:
Cell Type(s): Heart cell;
Channel(s): I L high threshold; I Sodium; I Potassium; Na/Ca exchanger; I_SERCA;
Gap Junctions:
Simulation Environment: C or C++ program;
Model Concept(s): Activity Patterns; Temporal Pattern Generation; Signaling pathways; Calcium dynamics;
Search NeuronDB for information about:  I L high threshold; I Sodium; I Potassium; Na/Ca exchanger; I_SERCA;
 *                                                                 *
 * File          : fnvector_parallel.c                             *
 * Programmers   : Radu Serban @ LLNL                              *
 * Version of    : 26 June 2002                                    *
 *                                                                 *
 * Copyright (c) 2002, The Regents of the University of California *
 * Produced at the Lawrence Livermore National Laboratory          *
 * All rights reserved                                             *
 * For details, see sundials/shared/LICENSE                        *
 * This file, companion of nvector_parallel.c contains the         *
 * implementation of the Fortran interface to M_EnvInit_Parallel   *
 * and M_EnvFree_Parallel.                                         *
 *                                                                 *

#include <stdio.h>
#include <stdlib.h>
#include "sundialstypes.h"
#include "nvector_parallel.h"
#include "fnvector_parallel.h"
#include "mpi.h"

/* Define global variable F2C_machEnv */
M_Env F2C_machEnv;

/* Fortran callable interfaces to M_EnvInit_Parallel
   and M_EnvFree_Parallel */

void F_MENVINITP(integertype *nlocal, integertype *nglobal, int *ier)
  /* Call M_EnvInit_Parallel:
     the first slot is for the communicator. 
     (From Fortran, only MPI_COMM_WORLD is allowed)
     *nlocal  is the local vector length
     *nglobal is the global vector length */

 int dumargc; char **dumargv;

 F2C_machEnv = M_EnvInit_Parallel(MPI_COMM_WORLD, *nlocal, *nglobal,
                                  &dumargc, &dumargv);

 *ier = (F2C_machEnv == NULL) ? -1 : 0 ;


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