Excitation-contraction coupling/mitochondrial energetics (ECME) model (Cortassa et al. 2006)

 Download zip file 
Help downloading and running models
Accession:105383
"An intricate network of reactions is involved in matching energy supply with demand in the heart. This complexity arises because energy production both modulates and is modulated by the electrophysiological and contractile activity of the cardiac myocyte. Here, we present an integrated mathematical model of the cardiac cell that links excitation-contraction coupling with mitochondrial energy generation. The dynamics of the model are described by a system of 50 ordinary differential equations. The formulation explicitly incorporates cytoplasmic ATP-consuming processes associated with force generation and ion transport, as well as the creatine kinase reaction. Changes in the electrical and contractile activity of the myocyte are coupled to mitochondrial energetics through the ATP, Ca21, and Na1 concentrations in the myoplasmic and mitochondrial matrix compartments. ..."
Reference:
1 . Cortassa S, Aon MA, Marbán E, Winslow RL, O'Rourke B (2003) An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys J 84:2734-55 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Electrogenic pump;
Brain Region(s)/Organism:
Cell Type(s): Heart cell;
Channel(s): I L high threshold; I Sodium; I Potassium; Na/Ca exchanger; I_SERCA;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: C or C++ program;
Model Concept(s): Activity Patterns; Temporal Pattern Generation; Signaling pathways; Calcium dynamics;
Implementer(s):
Search NeuronDB for information about:  I L high threshold; I Sodium; I Potassium; Na/Ca exchanger; I_SERCA; 
/*******************************************************************
 *                                                                 *
 * File          : fnvector_parallel.h                             *
 * Programmers   : Radu Serban @ LLNL                              *
 * Version of    : 29 March 2002                                   *
 *-----------------------------------------------------------------*
 * Copyright (c) 2002, The Regents of the University of California *
 * Produced at the Lawrence Livermore National Laboratory          *
 * All rights reserved                                             *
 * For details, see sundials/shared/LICENSE                        *
 *-----------------------------------------------------------------*
 * This file (companion of nvector_parallel.h) contains the        *
 * definitions needed for the Fortran callable wrappers to         *
 * M_EnvInit_Parallel and M_EnvFree_Parallel (these definitions    *
 * are based on the machine specific information for Fortran       *
 * externals given in the header file fcmixpar.h).                 *
 *******************************************************************/

#ifdef __cplusplus     /* wrapper to enable C++ usage */
extern "C" {
#endif

#ifndef included_fnvector_parallel_h
#define included_fnvector_parallel_h

#include "fcmixpar.h" /* Machine specific definitions for Fortran externals */

/* Fortran callable wrappers to M_EnvInit_Parallel and M_EnvFree_Parallel */ 

#if (CRAY)
  
#define F_MENVINITP  FMENVINITP
#define F_MENVFREEP  FMENVFREEP

#elif  (UNDERSCORE)

#define F_MENVINITP  fmenvinitp_
#define F_MENVFREEP  fmenvfreep_

#else

#define F_MENVINITP  fmenvinitp
#define F_MENVFREEP  fmenvfreep

#endif


#endif
#ifdef __cplusplus
}
#endif

Loading data, please wait...