Excitation-contraction coupling/mitochondrial energetics (ECME) model (Cortassa et al. 2006)

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Accession:105383
"An intricate network of reactions is involved in matching energy supply with demand in the heart. This complexity arises because energy production both modulates and is modulated by the electrophysiological and contractile activity of the cardiac myocyte. Here, we present an integrated mathematical model of the cardiac cell that links excitation-contraction coupling with mitochondrial energy generation. The dynamics of the model are described by a system of 50 ordinary differential equations. The formulation explicitly incorporates cytoplasmic ATP-consuming processes associated with force generation and ion transport, as well as the creatine kinase reaction. Changes in the electrical and contractile activity of the myocyte are coupled to mitochondrial energetics through the ATP, Ca21, and Na1 concentrations in the myoplasmic and mitochondrial matrix compartments. ..."
Reference:
1 . Cortassa S, Aon MA, Marbán E, Winslow RL, O'Rourke B (2003) An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys J 84:2734-55 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Electrogenic pump;
Brain Region(s)/Organism:
Cell Type(s): Heart cell;
Channel(s): I L high threshold; I Sodium; I Potassium; Na/Ca exchanger; I_SERCA;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: C or C++ program;
Model Concept(s): Activity Patterns; Temporal Pattern Generation; Signaling pathways; Calcium dynamics;
Implementer(s):
Search NeuronDB for information about:  I L high threshold; I Sodium; I Potassium; Na/Ca exchanger; I_SERCA;
!
! Initial conditions file for GPC 1.0
! Date: 2004.9.3 at 15:51 (ISO format: Year.Month.Date)
! Simulation time: 500000ms
! Number of states: 50
! 
! General
!
!  Format of the parameter file:
!    Comment lines start with !
!    Each input line starts with a number, then a space or a tab, after that can be anything until newline
!    Input lines have to be in certain order
!    Number of comment lines or empty lines is not limited
!	 Order of numbers is important, since they are read in the order shown here, regardless of comment
!
!        value     variable
V	= -85.6392
mNa	= 0.0328095
hNa	= 0.986907
jNa=      0.991685           
xKs=   0.000142496           
Nai=        6.8521           
 Ki=      143.009            
 Cai= 5.18688e-005           
 CaNSR=     0.182623         
  CaSS=5.44977e-005          
  CaJSR=    0.182665         
   C1_RyR=   0.940086        
 O2_RyR= 2.41394e-011        
  C2_RyR=0.0598432        
  C0=    0.999162            
 C1= 7.02417e-005            
C2=  1.85176e-009            
 C3= 2.16967e-014            
  C4=9.53308e-020            
Open=  1.42997e-020          
 CCa0=  0.000769686          
  CCa1=2.16439e-007          
 CCa2=2.28237e-011          
 CCa3= 1.06968e-015          
 CCa4=1.87999e-020          
      OCa=       0           
  yCa=    0.981582           
   LTRPNCa= 0.00803804       
    HTRPNCa=  0.131649       
     N0= 0.999889            
 N1= 1.65206e-005            
 P0= 1.91752e-005            
 P1= 1.65672e-005            
 P2= 3.09336e-005            
 P3= 2.69442e-005            
  ATPi_cyto=     7.77459     
   ATPi=     7.9903          
    CrPi_cyto=   12.2225     
    CrPi_mito=   12.8447     
  Cam=8.15443e-005           
   ADPm=  0.0709461          
     Dpsi=  154.226          
     NADH=  1.79227          
     ISOC=0.0522674          
 AKG= 4.54092e-005           
    SCoA=  0.903884          
  Succ= 0.000249084          
  FUM=   0.0148267           
   MAL= 0.00448343           
  Oaa=2.21673e-006  

//Mito Matlab version, get a good value from Sonia later
ASP = 1         

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