Temporal integration by stochastic recurrent network (Okamoto et al. 2007)

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Accession:105501
"Temporal integration of externally or internally driven information is required for a variety of cognitive processes. This computation is generally linked with graded rate changes in cortical neurons, which typically appear during a delay period of cognitive task in the prefrontal and other cortical areas. Here, we present a neural network model to produce graded (climbing or descending) neuronal activity. Model neurons are interconnected randomly by AMPA-receptor–mediated fast excitatory synapses and are subject to noisy background excitatory and inhibitory synaptic inputs. In each neuron, a prolonged afterdepolarizing potential follows every spike generation. Then, driven by an external input, the individual neurons display bimodal rate changes between a baseline state and an elevated firing state, with the latter being sustained by regenerated afterdepolarizing potentials. ..."
Reference:
1 . Okamoto H, Isomura Y, Takada M, Fukai T (2007) Temporal integration by stochastic recurrent network dynamics with bimodal neurons. J Neurophysiol 97:3859-67 [PubMed]
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Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s):
Channel(s): I Calcium;
Gap Junctions:
Receptor(s): GabaA; AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: C or C++ program;
Model Concept(s): Activity Patterns;
Implementer(s):
Search NeuronDB for information about:  GabaA; AMPA; I Calcium;
  
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Okamoto H, Isomura Y, Takada M, Fukai T (2007) Temporal integration by stochastic recurrent network dynamics with bimodal neurons. J Neurophysiol 97:3859-67[PubMed]

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