A dual-Ca2+-sensor model for neurotransmitter release in a central synapse (Sun et al. 2007)

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Accession:105506
"Ca2+-triggered synchronous neurotransmitter release is well described, but asynchronous release-in fact, its very existence-remains enigmatic. Here we report a quantitative description of asynchronous neurotransmitter release in calyx-of-Held synapses. ... Our results reveal that release triggered in wild-type synapses at low Ca2+ concentrations is physiologically asynchronous, and that asynchronous release completely empties the readily releasable pool of vesicles during sustained elevations of Ca2+. We propose a dual-Ca2+-sensor model of release that quantitatively describes the contributions of synchronous and asynchronous release under conditions of different presynaptic Ca2+ dynamics."
Reference:
1 . Sun J, Pang ZP, Qin D, Fahim AT, Adachi R, Sudhof TC (2007) A dual-Ca2+-sensor model for neurotransmitter release in a central synapse. Nature 450:676-82 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: IGOR Pro;
Model Concept(s): Calcium dynamics;
Implementer(s):
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Dual_sensor_model_code
readme.txt
Dual_sensor_model_code.txt
                            
This is the readme for the model associated with

Sun J, Pang ZP, Qin D, Fahim AT, Adachi R, Sudhof TC. 
A dual-Ca2+-sensor model for neurotransmitter release 
in a central synapse. Nature. 2007 Nov 29;450(7170):676-82.

The author's igor-pro function that defines the dual 
Ca2+ sensor is supplied.

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