Thalamocortical model of spike and wave seizures (Suffczynski et al. 2004)

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SIMULINK macroscopic model of transitions between normal (spindle) activity and spike and wave (SW) discharges in the thalamocortical network. The model exhibits bistability properties and stochastic fluctuations present in the network may flip the system between the two operational states. The predictions of the model were compared with real EEG data in rats and humans. A possibility to abort an ictal state by a single counter stimulus is suggested by the model.
1 . Suffczynski P, Kalitzin S, Lopes Da Silva FH (2004) Dynamics of non-convulsive epileptic phenomena modeled by a bistable neuronal network. Neuroscience 126:467-84 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neural mass;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I T low threshold; I Sodium; I Potassium;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA;
Transmitter(s): Acetylcholine; Gaba;
Simulation Environment: Simulink;
Model Concept(s): Oscillations; Epilepsy; Spindles;
Search NeuronDB for information about:  GabaA; GabaB; AMPA; I T low threshold; I Sodium; I Potassium; Acetylcholine; Gaba;
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