Spontaneous calcium oscillations in astrocytes (Lavrentovich and Hemkin 2008)

 Download zip file 
Help downloading and running models
Accession:112547
" ... We propose here a mathematical model of how spontaneous Ca2+ oscillations arise in astrocytes. This model uses the calcium-induced calcium release and inositol cross-coupling mechanisms coupled with a receptor-independent method for producing inositol (1,4,5)-trisphosphate as the heart of the model. By computationally mimicking experimental constraints we have found that this model provides results that are qualitatively similar to experiment."
Reference:
1 . Lavrentovich M, Hemkin S (2008) A mathematical model of spontaneous calcium(II) oscillations in astrocytes. J Theor Biol 251:553-60 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Electrogenic pump; Glia;
Brain Region(s)/Organism:
Cell Type(s): Astrocyte;
Channel(s):
Gap Junctions:
Receptor(s): IP3;
Gene(s):
Transmitter(s): Ions;
Simulation Environment: XPP;
Model Concept(s): Oscillations; Simplified Models; Signaling pathways; Calcium dynamics; Calcium waves;
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw];
Search NeuronDB for information about:  IP3; Ions;
Loading data, please wait...