Multiple mechanisms of short term plasticity at the calyx of Held (Hennig et al. 2008)

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Accession:113649
This is a new model of the short-term dynamics of glutamatergic synaptic transmission, which incorporates multiple mechanisms acting at differing sites and across a range of different time scales (ms to tens of seconds). In the paper, we show that this model can accurately reproduce the experimentally measured time-course of short term depression across different stimulus frequencies at the calyx of Held. The model demonstrates how multiple forms of activity-dependent modulation of release probability and vesicle pool depletion interact, and shows how stimulus-history-dependent recovery from synaptic depression can arise from dynamics on multiple time scales.
Reference:
1 . Hennig MH, Postlethwaite M, Forsythe ID, Graham BP (2008) Interactions between multiple sources of short term plasticity during evoked and spontaneous activity at the rat calyx of Held J Physiol 586(13):3129-3146 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Medial Nucleus of the Trapezoid Body (MNTB) neuron;
Channel(s): I Calcium;
Gap Junctions:
Receptor(s): AMPA; mGluR;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: MATLAB;
Model Concept(s): Short-term Synaptic Plasticity;
Implementer(s): Hennig, Matthias H [mhhennig at gmail.com];
Search NeuronDB for information about:  AMPA; mGluR; I Calcium; Glutamate;
  
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CalyxSTPModel
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fig2.m
mean_epscs.mat
releasef.m
screenshot.jpg
synOde.m
                            

Hennig MH, Postlethwaite M, Forsythe ID, Graham BP (2008) Interactions between multiple sources of short term plasticity during evoked and spontaneous activity at the rat calyx of Held J Physiol 586(13):3129-3146[PubMed]

References and models cited by this paper

References and models that cite this paper

Yang Z, Hennig MH, Postlethwaite M, Forsythe ID, Graham BP (2009) Wide-band information transmission at the calyx of held. Neural Comput 21:991-1017 [Journal] [PubMed]

  • Calyx of Held, short term plasticity (Yang Z et al. 2009) [Model]

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