Hippocampal basket cell gap junction network dynamics (Saraga et al. 2006)

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Accession:114047
2 cell network of hippocampal basket cells connected by gap junctions. Paper explores how distal gap junctions and active dendrites can tune network dynamics.
Reference:
1 . Saraga F, Ng L, Skinner FK (2006) Distal gap junctions and active dendrites can tune network dynamics. J Neurophysiol 95:1669-82 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 basket cell; Abstract Wang-Buzsaki neuron;
Channel(s): I Na,t; I K;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Oscillations; Active Dendrites; Action Potentials; Electrotonus; Delay;
Implementer(s): Saraga, Fernanda [Fernanda.Saraga at utoronto.ca];
Search NeuronDB for information about:  I Na,t; I K; Gaba;
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Basketcell
README.HTML
gap.mod
hh.mod
cella.hoc
cellb.hoc
default_init.hoc
extras.hoc
fig6.hoc
freq.hoc
gapdist.hoc
gapdist.ses
gapmid.hoc
gapmid.ses
gapprox.hoc
gapprox.ses
init.hoc
initdist.hoc
initmid.hoc
initprox.hoc
maxvalue.hoc
minvalue.hoc
mosinit.hoc *
phaselag.hoc
prog.hoc
screenshot.jpg
state.hoc
state_init0.hoc
state_init1.hoc
xyvalues.hoc
                            
proc celldef() {
  topol()
  subsets()
  geom()
  biophys()
  geom_nseg()
}

create somaa, dend1a, dend2a, dend3a[9], dend4a[10]

proc topol() { local i
  connect dend1a(0), somaa(0)
  connect dend2a(0), somaa(1)
  connect dend3a(0), somaa(0)
  for i = 1, 2 connect dend3a[i](0), dend3a[i-1](1)
  connect dend3a[3](0), dend3a[1](1)
  connect dend3a[4](0), dend3a(1)
  for i = 5, 6 connect dend3a[i](0), dend3a[i-1](1)
  connect dend3a[7](0), dend3a[5](1)
  connect dend3a[8](0), dend3a[4](1)
  connect dend4a(0), somaa(1)
  for i = 1, 3 connect dend4a[i](0), dend4a[i-1](1)
  connect dend4a[4](0), dend4a[2](1)
  connect dend4a[5](0), dend4a[1](1)
  for i = 6, 7 connect dend4a[i](0), dend4a[5](1)
  for i = 8, 9 connect dend4a[i](0), dend4a[7](1)
  basic_shape()
}
proc basic_shape() {
  somaa {pt3dclear() pt3dadd(0, 0, 0, 1) pt3dadd(15, 0, 0, 1)}
  dend1a {pt3dclear() pt3dadd(0, 0, 0, 1) pt3dadd(-44, -149, 0, 1)}
  dend2a {pt3dclear() pt3dadd(15, 0, 0, 1) pt3dadd(75, -149, 0, 1)}
  dend3a {pt3dclear() pt3dadd(0, 0, 0, 1) pt3dadd(-14, 15, 0, 1)}
  dend3a[1] {pt3dclear() pt3dadd(-14, 15, 0, 1) pt3dadd(-89, 120, 0, 1)}
  dend3a[2] {pt3dclear() pt3dadd(-89, 120, 0, 1) pt3dadd(-119, 135, 0, 1)}
  dend3a[3] {pt3dclear() pt3dadd(-89, 120, 0, 1) pt3dadd(-104, 165, 0, 1)}
  dend3a[4] {pt3dclear() pt3dadd(-14, 15, 0, 1) pt3dadd(-14, 45, 0, 1)}
  dend3a[5] {pt3dclear() pt3dadd(-14, 45, 0, 1) pt3dadd(-44, 120, 0, 1)}
  dend3a[6] {pt3dclear() pt3dadd(-44, 120, 0, 1) pt3dadd(-74, 150, 0, 1)}
  dend3a[7] {pt3dclear() pt3dadd(-44, 120, 0, 1) pt3dadd(-59, 165, 0, 1)}
  dend3a[8] {pt3dclear() pt3dadd(-14, 45, 0, 1) pt3dadd(0, 165, 0, 1)}
  dend4a {pt3dclear() pt3dadd(15, 0, 0, 1) pt3dadd(30, 30, 0, 1)}
  dend4a[1] {pt3dclear() pt3dadd(30, 30, 0, 1) pt3dadd(45, 60, 0, 1)}
  dend4a[2] {pt3dclear() pt3dadd(45, 60, 0, 1) pt3dadd(45, 135, 0, 1)}
  dend4a[3] {pt3dclear() pt3dadd(45, 135, 0, 1) pt3dadd(30, 165, 0, 1)}
  dend4a[4] {pt3dclear() pt3dadd(45, 135, 0, 1) pt3dadd(75, 150, 0, 1)}
  dend4a[5] {pt3dclear() pt3dadd(45, 60, 0, 1) pt3dadd(60, 75, 0, 1)}
  dend4a[6] {pt3dclear() pt3dadd(60, 75, 0, 1) pt3dadd(60, 165, 0, 1)}
  dend4a[7] {pt3dclear() pt3dadd(60, 75, 0, 1) pt3dadd(105, 150, 0, 1)}
  dend4a[8] {pt3dclear() pt3dadd(105, 150, 0, 1) pt3dadd(60, 195, 0, 1)}
  dend4a[9] {pt3dclear() pt3dadd(105, 150, 0, 1) pt3dadd(135, 195, 0, 1)}
}
proc position() { local i, x, y, z
  x = x3d(0)  y = y3d(0)  z = z3d(0)
  for i = 0, n3d()-1 {
    pt3dchange(i, $1-x+x3d(i), $2-y+y3d(i), $3-z+z3d(i), diam3d(i))
  }
}  


objref all
proc subsets() { local i
  objref all
  all = new SectionList()

}
proc geom() {
  somaa {  /*area = 1000 */ L = diam = 17.8412  }
  dend1a {  L = 301.79  diam = 1.1839  }
  dend2a {  L = 336.59  diam = 1.2684  }
  dend3a {  L = 26.962  diam = 1.7231  }
  dend3a[1] {  L = 341.15  diam = 2  }
  dend3a[2] {  L = 72.155  diam = 1.0547  }
  dend3a[3] {  L = 99.341  diam = 1.004  }
  dend3a[4] {  L = 23.133  diam = 2  }
  dend3a[5] {  L = 214.38  diam = 2  }
  dend3a[6] {  L = 187.79  diam = 0.90954  }
  dend3a[7] {  L = 131.39  diam = 0.92304  }
  dend3a[8] {  L = 366.07  diam = 1.7639  }
  dend4a {  L = 19.975  diam = 1.6653  }
  dend4a[1] {  L = 25.821  diam = 5  }
  dend4a[2] {  L = 278.6  diam = 2.1053  }
  dend4a[3] {  L = 151.32  diam = 0.98245  }
  dend4a[4] {  L = 70.834  diam = 1.0067  }
  dend4a[5] {  L = 32.708  diam = 3.0486  }
  dend4a[6] {  L = 333.13  diam = 0.97876  }
  dend4a[7] {  L = 201.11  diam = 2  }
  dend4a[8] {  L = 222.95  diam = 1.3644  }
  dend4a[9] {  L = 169.17  diam = 1.4889  }
}
proc geom_nseg() {
   dend1a { nseg = 31  }
   dend2a { nseg = 34  }
   dend3a { nseg = 3  }
   dend3a[1] { nseg = 34  }
   dend3a[2] { nseg = 8  }
   dend3a[3] { nseg = 10  }
   dend3a[4] { nseg = 3  }
   dend3a[5] { nseg = 22  }
   dend3a[6] { nseg = 19  }
   dend3a[7] { nseg = 14  }
   dend3a[8] { nseg = 37  }
   dend4a { nseg = 2  }
   dend4a[1] { nseg = 3  }
   dend4a[2] { nseg = 28  }
   dend4a[3] { nseg = 16  }
   dend4a[4] { nseg = 8  }
   dend4a[5] { nseg = 4  }
   dend4a[6] { nseg = 34  }
   dend4a[7] { nseg = 21  }
   dend4a[8] { nseg = 23  }
   dend4a[9] { nseg = 17  }
}
proc biophys() {
}

access somaa

celldef()

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