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Efffect of propofol on potassium current in cardiac H9c2 cells (Liu et al. 2008)
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"... The effects of propofol, an intravenous anesthetic agent with a distinct chemical structure, on ion currents of differentiated clonal cardiac (H9c2) cells were investigated in this study. Propofol ... suppressed the amplitude of delayed rectifier K(+) current (I(K(DR))) in a concentration-dependent manner with an IC(50) value of 36 muM. ... Propofol (30 muM) had no effect on erg-mediated K(+) current in these cells; however, it suppressed L-type Ca(2+) current (I(Ca,L)) of cardiac and skeletal types to a similar extent. ... Numerical simulations of I(K(DR)) based on a Markovian model reproduce the experimental results and show that propofol-induced blockade of I(K(DR)) is associated with an decrease in forward rate of the activation process and an increase in transitional rate into the inactivated state. ..."
Liu YC, Wang YJ, Wu SN (2008) The mechanisms of propofol-induced block on ion currents in differentiated H9c2 cardiac cells.
Eur J Pharmacol
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Ion Channel Kinetics;
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