CaMKII system exhibiting bistability with respect to calcium (Graupner and Brunel 2007)

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Accession:114452
"... We present a detailed biochemical model of the CaMKII autophosphorylation and the protein signaling cascade governing the CaMKII dephosphorylation. ... it is shown that the CaMKII system can qualitatively reproduce results of plasticity outcomes in response to spike-timing dependent plasticity (STDP) and presynaptic stimulation protocols. This shows that the CaMKII protein network can account for both induction, through LTP/LTD-like transitions, and storage, due to its bistability, of synaptic changes."
Reference:
1 . Graupner M, Brunel N (2007) STDP in a bistable synapse model based on CaMKII and associated signaling pathways. PLoS Comput Biol 3:e221 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: XPP;
Model Concept(s): Detailed Neuronal Models; Synaptic Plasticity; Long-term Synaptic Plasticity; Signaling pathways;
Implementer(s): Graupner, Michael [michael.graupner at ens.fr];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell;
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