Pyramidal neurons switch from integrators to resonators (Prescott et al. 2008)

 Download zip file 
Help downloading and running models
Accession:116386
During wakefulness, pyramidal neurons in the intact brain are bombarded by synaptic input that causes tonic depolarization, increased membrane conductance (i.e. shunting), and noisy fluctuations in membrane potential; by comparison, pyramidal neurons in acute slices typically experience little background input. Such differences in operating conditions can compromise extrapolation of in vitro data to explain neuronal operation in vivo. ... in slice experiments, we show that CA1 hippocampal pyramidal cells switch from integrators to resonators, i.e. from class 1 to class 2 excitability. The switch is explained by increased outward current contributed by the M-type potassium current IM ... Thus, even so-called “intrinsic” properties may differ qualitatively between in vitro and in vivo conditions.
Reference:
1 . Prescott SA, Ratte S, De Koninck Y, Sejnowski TJ (2008) Pyramidal neurons switch from integrators in vitro to resonators under in vivo-like conditions. J Neurophysiol [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Abstract Morris-Lecar neuron;
Channel(s): I Na,t; I K; I M;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: XPP;
Model Concept(s): Oscillations; Simplified Models; Synaptic Integration; Bifurcation;
Implementer(s): Prescott, Steven [steve.prescott at sickkids.ca]];
Search NeuronDB for information about:  I Na,t; I K; I M;
Loading data, please wait...