Spike frequency adaptation in the LGMD (Peron and Gabbiani 2009)

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Accession:116945
This model is used in the referenced paper to demonstrate that a model of an SK-like calcium-sensitive potassium (KCa) conductance can replicate the spike frequency adaptation (SFA) of the locust lobula giant movement detector (LGMD) neuron. The model simulates current injection experiments with and without KCa block in the LGMD, as well as visual stimulation experiments with and without KCa block.
Reference:
1 . Peron S, Gabbiani F (2009) Spike frequency adaptation mediates looming stimulus selectivity in a collision-detecting neuron. Nat Neurosci 12:318-26 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Locust Lobula Giant Movement Detector (LGMD) neuron;
Channel(s): I Na,t; I K,Ca; I Calcium; I Krp;
Gap Junctions:
Receptor(s): GabaA; Cholinergic Receptors;
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Spike Frequency Adaptation; Vision;
Implementer(s): Gabbiani, F; Peron, Simon [perons at janelia.hhmi.org];
Search NeuronDB for information about:  GabaA; Cholinergic Receptors; I Na,t; I K,Ca; I Calcium; I Krp;
%
% returns the curinj vector for a particular l/v
%
function [I_of_t max_time]= get_curinj_vec(l_over_v, I_max, I_base)
	theta_0 = 2;
	theta_f = 62;
	t_f = -1*l_over_v/tand(theta_f);
	t_0 = -1*l_over_v/tand(theta_0);

	t_vec = t_0:0.1:t_f;
	inj_vec = -1*atand(l_over_v./t_vec);
	inj_vec = I_max * inj_vec/max(inj_vec); % scale to max
	I_of_t = I_base*ones(1,20001);
	I_of_t(5000:5000+length(inj_vec)-1) = inj_vec';

	[irr max_idx] = max(I_of_t);
	max_time = max_idx/10;


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