Experimental and modeling studies of desensitization of P2X3 receptors (Sokolova et al. 2006)

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Accession:117691
"The function of ATP-activated P2X3 receptors involved in pain sensation is modulated by desensitization, a phenomenon poorly understood. The present study used patch-clamp recording from cultured rat or mouse sensory neurons and kinetic modeling to clarify the properties of P2X3 receptor desensitization. ... Desensitization properties were well accounted for by a cyclic model in which receptors could be desensitized from either open or closed states. Recovery was assumed to be a multistate process with distinct kinetics dependent on the agonist-dependent dissociation rate from desensitized receptors. ... By using subthreshold concentrations of an HAD (high-affinity desensitization)-potent agonist, it might be possible to generate sustained inhibition of P2X3 receptors for controlling chronic pain."
Reference:
1 . Sokolova E, Skorinkin A, Moiseev I, Agrachev A, Nistri A, Giniatullin R (2006) Experimental and modeling studies of desensitization of P2X3 receptors. Mol Pharmacol 70:373-82 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): Sensory Receptors;
Gene(s):
Transmitter(s):
Simulation Environment: Pascal/Delphi;
Model Concept(s): Ion Channel Kinetics; Nociception;
Implementer(s): Skorinkin, Andrei [askorink at yandex.ru];
Search NeuronDB for information about:  Sensory Receptors; 
This is the readme for the model associated with the paper:

Sokolova E, Skorinkin A, Moiseev I, Agrachev A, Nistri A, Giniatullin R (2006)
Experimental and modeling studies of desensitization of P2X3 receptors.
Mol Pharmacol 70:373-82

These model files were supplied by Dr Andrei Skorinkin.

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DS_especial.dpr

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