Gap junction coupled network of striatal fast spiking interneurons (Hjorth et al. 2009)

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Accession:118389
Gap junctions between striatal FS neurons has very weak ability to synchronise spiking. Input uncorrelated between neighbouring neurons is shunted, while correlated input is not.
Reference:
1 . Hjorth J, Blackwell KT, Kotaleski JH (2009) Gap junctions between striatal fast-spiking interneurons regulate spiking activity and synchronization as a function of cortical activity. J Neurosci 29:5276-86 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Synapse; Channel/Receptor; Dendrite;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum fast spiking interneuron;
Channel(s): I A; I_K,Na;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS; MATLAB;
Model Concept(s): Activity Patterns; Ion Channel Kinetics; Synchronization; Detailed Neuronal Models;
Implementer(s): Hjorth, Johannes [hjorth at csc.kth.se];
Search NeuronDB for information about:  I A; I_K,Na; Gaba; Glutamate;
To generate figure 5A, which uses the same base-code as Figure 2, go
into the FIG2 directory and run the matlab scripts:

runTwoFSwithGJforIFplots.m
readIFSscanFSpair.m
makeIFplots.m

FS-IFplot-effect-of-neighbour-input.eps


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In the FIG5BC directory, run the following matlab scripts to generate
data for fig 5B and 5C.

If you just want to see it run, then make sure to lower nReps and
maxTime, or you will have to be *very* patient. You might also want to
modify the pMixRange by lowering 5 to 3.

runTenInhomoFSGJcorrVariationSaveGJcur
readTenInhomoFScorrVarWithGJcur

To make figure 5B:
makeTenInhomoFScorrVar

To make figure 5C:
makeSpikeCenteredGJcurPlot


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To generate figure 5D, go to FIG5D directory.


To run simulation:
runTenFScurInjectHomogeneNetworkGJonoff.m

Run
compareTraces.m

When asked for a file, input:

'UTDATA/SAVED/TenHomoFSGJonoffCurInject/TenHomoFS-prim-CurInject-GJonoff-id210991775-gapres-2000000compareTraces'

Obs, you might have to replace the randomId in idXXXXXXXXXX with your number.


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