STDP promotes synchrony of inhibitory networks in the presence of heterogeneity (Talathi et al 2008)

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Accession:119159
"Recently Haas et al. (J Neurophysiol 96: 3305–3313, 2006), observed a novel form of spike timing dependent plasticity (iSTDP) in GABAergic synaptic couplings in layer II of the entorhinal cortex. Depending on the relative timings of the presynaptic input at time tpre and the postsynaptic excitation at time tpost, the synapse is strengthened (delta_t = t(post) - t(pre) > 0) or weakened (delta_t < 0). The temporal dynamic range of the observed STDP rule was found to lie in the higher gamma frequency band (> or = 40 Hz), a frequency range important for several vital neuronal tasks. In this paper we study the function of this novel form of iSTDP in the synchronization of the inhibitory neuronal network. In particular we consider a network of two unidirectionally coupled interneurons (UCI) and two mutually coupled interneurons (MCI), in the presence of heterogeneity in the intrinsic firing rates of each coupled neuron. ..."
Reference:
1 . Talathi SS, Hwang DU, Ditto WL (2008) Spike timing dependent plasticity promotes synchrony of inhibitory networks in the presence of heterogeneity. J Comput Neurosci 25:262-81 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Entorhinal cortex;
Cell Type(s):
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): GabaA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: C or C++ program;
Model Concept(s): STDP;
Implementer(s): Talathi Sachin [talathi at ufl.edu];
Search NeuronDB for information about:  GabaA; Gaba; I Na,t; I K;
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TalathiEtAl2008
C++HH
simul_lrn
README.txt
                            
This is the readme for the models associated with the paper

Talathi SS, Hwang DU, Ditto WL (2008) Spike timing dependent
plasticity promotes synchrony of inhibitory networks in the presence
of heterogeneity. J Comput Neurosci 25:262-81

Usage:

The Main Code is ./C++HH/Codes/InhibLearning/Test_Slow_Syn.cc

The accompanying make file Make_Inhib_Slow.f will allow to compile the code
to generate the executable run_slow_compute.

Example runs are provided in the perlscript TestRun.pl which generates the
data files, used to produce the two sample figures Learning.pdf and
NoLearning.pdf

Compile the make file on terminal through commannd

$ make -f Make_Inhib_Slow.f

It will generate the executable run_slow_compute

Run the perl script TestRun.pl.

It will generate two data files BiDirecLearn.dat and BiDirecNoLearn.dat

The voltage trace of the two neurons is the 2nd and 3rd column of
these dat files.

The Figures Learning.pdf and NoLearning.pdf represent the plotted
Figures from the data files above.

-Sachin S Talathi

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