"A three-dimensional presynaptic calcium diffusion model developed to account for characteristics of transmitter release
was modified to provide for binding of calcium to a receptor and subsequent triggering of exocytosis.
When low affinity (20 FLM) and
rapid kinetics were assumed for the calcium receptor triggering exocytosis, and stimulus parameters were selected to match those
of experiments, the simulations predicted a virtual invariance of the time course of transmitter release to paired stimulation,
stimulation with pulses of different amplitude, and stimulation in different calcium solutions.
Matveev V, Sherman A, Zucker RS (2002) New and corrected simulations of synaptic facilitation. Biophys J 83:1368-73 [PubMed]