TTX-R Na+ current effect on cell response (Herzog et al 2001) (MATLAB)

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Accession:120117
"Small dorsal root ganglion (DRG) neurons, which include nociceptors, express multiple voltage-gated sodium currents. In addition to a classical fast inactivating tetrodotoxin-sensitive (TTX-S) sodium current, many of these cells express a TTX-resistant (TTX-R) sodium current that activates near -70 mV and is persistent at negative potentials. To investigate the possible contributions of this TTX-R persistent (TTX-RP) current to neuronal excitability, we carried out computer simulations using the Neuron program with TTX-S and -RP currents, fit by the Hodgkin-Huxley model, that closely matched the currents recorded from small DRG neurons. ..." See paper for more and details.
Reference:
1 . Herzog RI, Cummins TR, Waxman SG (2001) Persistent TTX-resistant Na+ current affects resting potential and response to depolarization in simulated spinal sensory neurons. J Neurophysiol 86:1351-64 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Na,p; I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Ion Channel Kinetics; Nociception;
Implementer(s): Andersson, Thomas [toma at math.su.se];
Search NeuronDB for information about:  I Na,p; I Na,t; I K;
% FUNCTION "NATR" - CALCULATION OF STATIONARY DISTRIBUTION
% AND TIME CONSTANT FOR Na TTX-R

function [tmNatr,pmNatr,thNatr,phNatr,tsNatr,psNatr]=Natr(V)
am=1.032/(1+exp((V+6.99)/-14.8712));
bm=5.79/(1+exp((V+130.4)/22.9));
ah=0.06435/(1+exp((V+73.26)/3.719));
bh=0.135/(1+exp((V+10.28)/-9.093));
as=0.00000016*exp(-(V)/12);
bs=0.0005/(1+exp(-(V+32)/23));
tmNatr=1/(am+bm);
pmNatr=am/(am+bm);
thNatr=1/(ah+bh);
phNatr=ah/(ah+bh);
tsNatr=1/(as+bs);
psNatr=as/(as+bs);
return

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