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A kinetic model unifying presynaptic short-term facilitation and depression (Lee et al. 2009)
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"... Here, we propose a unified theory of synaptic short-term plasticity based on realistic yet tractable and testable model descriptions of the underlying intracellular biochemical processes. Analysis of the model equations leads to a closed-form solution of the resonance frequency, a function of several critical biophysical parameters, as the single key indicator of the propensity for synaptic facilitation or depression under repetitive stimuli. This integrative model is supported by a broad range of transient and frequency response experimental data including those from facilitating, depressing or mixed-mode synapses. ... the model provides the reasons behind the switching behavior between facilitation and depression observed in experiments. ..."
Lee CC, Anton M, Poon CS, McRae GJ (2009) A kinetic model unifying presynaptic short-term facilitation and depression.
J Comput Neurosci
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Hippocampus CA1 pyramidal GLU cell;
Cerebellum Purkinje GABA cell;
Lee, Chuang-Chung [chchlee at alum.mit.edu];
Anton, Mihai [mianton at mit.edu];
Poon, Chi-Sang [cpoon at mit.edu];
McRae, Gregory [mcrae at mit.edu];
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Hippocampus CA1 pyramidal GLU cell
Cerebellum Purkinje GABA cell
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