Action potential of adult rat ventricle (Wang et al. 2008)

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Accession:120246
"Aconitine (ACO), a highly toxic diterpenoid alkaloid, is recognized to have effects on cardiac voltage-gated Na(+) channels. However, it remains unknown whether it has any effects on K(+) currents. The effects of ACO on ion currents in differentiated clonal cardiac (H9c2) cells and in cultured neonatal rat ventricular myocytes were investigated in this study. ..." The rat action potential in this simulation was played back into the cell for experiments reported in this paper.
Reference:
1 . Wang YJ, Chen BS, Lin MW, Lin AA, Peng H, Sung RJ, Wu SN (2008) Time-Dependent Block of Ultra-Rapid Delayed Rectifier K+ Currents by Aconitine, a Potent Cardiotoxin, in Heart-Derived H9c2 Myoblasts and in Neonatal Rat Ventricular Myocytes. Toxicol Sci 106(2):454-463 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cardiac ventricular cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: XPP;
Model Concept(s): Action Potentials;
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw];
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RatAP
readme.html
RatAP.JPG
RatAPtest01.ode
                            
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