Membrane potential changes in dendritic spines during APs and synaptic input (Palmer & Stuart 2009)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:120798
" ... Finally, we used simulations of our experimental observations in morphologically realistic models to estimate spine neck resistance. These simulations indicated that spine neck resistance ranges up to ~500 M Ohm. Spine neck resistances of this magnitude reduce somatic EPSPs by ~15%, indicating that the spine neck is unlikely to act as a physical device to significantly modify synaptic strength."
Reference:
1 . Palmer LM, Stuart GJ (2009) Membrane potential changes in dendritic spines during action potentials and synaptic input. J Neurosci 29:6897-903 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites; Influence of Dendritic Geometry; Synaptic Integration;
Implementer(s): Morse, Tom [Tom.Morse at Yale.edu]; Stuart, Greg J. [greg.stuart at anu.edu.au];
// program to get geometry and initialise properties of Ri18//

load_file("nrngui.hoc")

xopen("Ri18geometry.hoc")
xopen("Ri18init_passive.hoc")

access dend1[14]    /* middle of the soma */

t=0
tstop=30
steps_per_ms=20
dt=0.05


// xopen("Fig.5B.ses") replaced with code in fig5.hoc

print "Ri18 active model successfully built\n"

// additional scripts from ModelDB Admin.
xopen("insert_synapses.hoc")  // add g_syn EPSP point processes
dend1[13] distance() // set origin at middle of soma
print "distance from spine synapses to soma:"
forsec "neck" print secname(),", ",distance(0.5)

xopen("soma_spine_v_graph.ses")
xopen("iclamp_supfig2.ses")
xopen("run_cntrl.ses")

// turn the spine off for now
for i=0,2 {
  syn[i].gmax=0 // nominally 0.0005
}
load_file("suppl_fig2c.hoc")
load_file("fig5.hoc") // contains fig5b(), fig5c()

xpanel("Palmer and Stuart, 2009")
  xlabel("Click below to run the model to recreate:")
  xbutton("Fig. 5B","fig5b()")
  xbutton("Fig. 5C, D","fig5cd()")
  xbutton("Suppl. Fig. 2 c","suppl_fig2c()")
xpanel()


Loading data, please wait...