Membrane potential changes in dendritic spines during APs and synaptic input (Palmer & Stuart 2009)

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Accession:120798
" ... Finally, we used simulations of our experimental observations in morphologically realistic models to estimate spine neck resistance. These simulations indicated that spine neck resistance ranges up to ~500 M Ohm. Spine neck resistances of this magnitude reduce somatic EPSPs by ~15%, indicating that the spine neck is unlikely to act as a physical device to significantly modify synaptic strength."
Reference:
1 . Palmer LM, Stuart GJ (2009) Membrane potential changes in dendritic spines during action potentials and synaptic input. J Neurosci 29:6897-903 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites; Influence of Dendritic Geometry; Synaptic Integration;
Implementer(s): Morse, Tom [Tom.Morse at Yale.edu]; Stuart, Greg J. [greg.stuart at anu.edu.au];
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