A model of beta-adrenergic modulation of IKs in the guinea-pig ventricle (Severi et al. 2009)

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Detailed understanding of IKs gating complexity may provide clues on the mechanisms of cardiac repolarization instability and the resulting arrhythmias. We developed and tested a kinetic Markov model to interpret physiologically relevant IKs properties, including pause-dependency and modulation by beta-adrenergic receptors (beta-AR). The model was developed from the Silva & Rudy formulation. Parameters were optimized on control and ISO experimental data, respectively.
1 . Severi S, Corsi C, Rocchetti M, Zaza A (2009) Mechanisms of beta-adrenergic modulation of I(Ks) in the guinea-pig ventricle: insights from experimental and model-based analysis. Biophys J 96:3862-72 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Cardiac ventricular cell;
Channel(s): I_Ks;
Gap Junctions:
Simulation Environment: Simulink;
Model Concept(s): Ion Channel Kinetics; Markov-type model;
Implementer(s): Severi, Stefano [stefano.severi at unibo.it];
Search NeuronDB for information about:  I_Ks;
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