"To better understand the direct effects of DBS (Deep brain stimulation) on central neurons, a computational model of a myelinated axon has been constructed which includes the effects of K+ accumulation within the peri-axonal space.
Using best estimates of anatomic and electrogenic model parameters for in vivo STN axons, the model predicts a functional block along the axon due to K+ accumulation in the submyelin space.
These results suggest that therapeutic DBS of the STN likely results in a functional block for many STN axons, although a subset of STN axons may also be activated at the stimulating frequency.
Bellinger SC, Miyazawa G, Steinmetz PN (2008) Submyelin potassium accumulation may functionally block subsets of local axons during deep brain stimulation: a modeling study. J Neural Eng 5:263-74 [PubMed]