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Submyelin Potassium accumulation in Subthalamic neuron (STN) axons (Bellinger et al. 2008)
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"To better understand the direct effects of DBS (Deep brain stimulation) on central neurons, a computational model of a myelinated axon has been constructed which includes the effects of K+ accumulation within the peri-axonal space. Using best estimates of anatomic and electrogenic model parameters for in vivo STN axons, the model predicts a functional block along the axon due to K+ accumulation in the submyelin space. ... These results suggest that therapeutic DBS of the STN likely results in a functional block for many STN axons, although a subset of STN axons may also be activated at the stimulating frequency. "
Bellinger SC, Miyazawa G, Steinmetz PN (2008) Submyelin potassium accumulation may functionally block subsets of local axons during deep brain stimulation: a modeling study.
J Neural Eng
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Subthalamus nucleus projection neuron;
Axonal Action Potentials;
Deep brain stimulation;
Bellinger, Steven [Steve.Bellinger at asu.edu];
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