Find models by
Find models for
Find models of
Electrical synapses (gap junctions)
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
Tight junction model of CNS myelinated axons (Devaux and Gow 2008)
Download zip file
Help downloading and running models
Two models are included: 1) a myelinated axon is represented by an equivalent circuit with a double cable design but includes a tight junction in parallel with the myelin membrane RC circuit (called double cable model, DCM). 2) a myelinated axon is represented by an equivalent circuit with a double cable design but includes a tight junction in series with the myelin RC circuit (called tight junction model, TJM). These models have been used to simulate data from compound action potentials measured in mouse optic nerve from Claudin 11-null mice in Fig. 6 of: Devaux, J.J. & Gow, A. (2008) Tight Junctions Potentiate The Insulative Properties Of Small CNS Myelinated Axons. J Cell Biol 183, 909-921.
Devaux J, Gow A (2008) Tight junctions potentiate the insulative properties of small CNS myelinated axons.
J Cell Biol
Gow A, Devaux J (2008) A model of tight junction function in central nervous system myelinated axons.
Neuron Glia Biol
(Click on a link to find other models with that property)
Axonal Action Potentials;
for information about:
File not selected
<- Select file from this column.
Load Model Views
Double Cable Model (DCM)
Tight Junction Model (TJM)
Loading data, please wait...