"We investigate the effects of the stochastic nature
of ion channels on the faithfulness, precision and reproducibility
of electrical signal transmission in weakly active,
dendritic membrane under in vitro conditions.
We numerically simulate the effects of stochastic ion
channels on the forward and backward propagation of dendritic
spikes in Monte-Carlo simulations on a reconstructed
layer 5 pyramidal neuron.
We report that in most instances
there is little variation in timing or amplitude for a single
BPAP, while variable backpropagation can occur for trains
of action potentials.
Additionally, we find that the generation
and forward propagation of dendritic Ca2+ spikes are
susceptible to channel variability. This indicates limitations
on computations that depend on the precise timing of Ca2+
Diba K, Koch C, Segev I (2006) Spike propagation in dendrites with stochastic ion channels. J Comput Neurosci 20:77-84 [PubMed]