Respiratory central pattern generator network in mammalian brainstem (Rubin et al. 2009)

 Download zip file 
Help downloading and running models
This model is a reduced version of a spatially organized respiratory central pattern generation network consisting of four neuronal populations (pre-I, early-I, post-I, and aug-E). In this reduction, each population is represented by a single neuron, in an activity-based framework (which includes the persistent sodium current for the pre-I population). The model includes three sources of external drive and can produce several experimentally observed rhythms.
1 . Rubin JE, Shevtsova NA, Ermentrout GB, Smith JC, Rybak IA (2009) Multiple rhythmic states in a model of the respiratory central pattern generator. J Neurophysiol 101:2146-65 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Respiratory column neuron;
Channel(s): I Na,p;
Gap Junctions:
Receptor(s): AMPA; Gaba;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: XPP;
Model Concept(s): Temporal Pattern Generation;
Implementer(s): Rubin, Jonathan E [jonrubin at];
Search NeuronDB for information about:  AMPA; Gaba; I Na,p; Gaba; Glutamate;
Loading data, please wait...