Here, theoretical analyses reveal that excitatory synaptic
strength controls the threshold of the neuronal
input-output function, while inhibitory plasticity
alters the threshold and gain.
Experimentally, changes in the balance of excitation and inhibition
in CA1 pyramidal neurons also altered their input-output
function as predicted by the model.
These results support the existence of two functional
modes of plasticity that can be used to optimize
information processing: threshold and gain plasticity."
Carvalho TP, Buonomano DV (2009) Differential effects of excitatory and inhibitory plasticity on synaptically driven neuronal input-output functions. Neuron 61:774-85 [PubMed]