Calcium waves in neuroblastoma cells (Fink et al. 2000)

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Accession:125745
Uses a model of IP3-mediated release of Ca from endoplasmic reticulum (ER) to study how initiation and propagation of Ca waves are affected by cell geometry, spatial distributions of ER and IP3 generation, and diffusion of Ca and mobile buffer.
Reference:
1 . Fink CC, Slepchenko B, Moraru II, Watras J, Schaff JC, Loew LM (2000) An image-based model of calcium waves in differentiated neuroblastoma cells. Biophys J 79:163-83 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Unknown;
Cell Type(s): Neuroblastoma;
Channel(s): I_SERCA;
Gap Junctions:
Receptor(s): IP3;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Virtual Cell (web link to model);
Model Concept(s): Calcium dynamics; Calcium waves;
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu]; Fink, Charles C [cfink at uwm.edu];
Search NeuronDB for information about:  IP3; I_SERCA;
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