Find models by
Find models for
Find models of
Electrical synapses (gap junctions)
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
A kinetic model of dopamine- and calcium-dependent striatal synaptic plasticity (Nakano et al. 2010)
Download zip file
Help downloading and running models
A signaling pathway model of spines that express D1-type dopamine receptors was constructed to analyze the dynamic mechanisms of dopamine- and calcium-dependent plasticity. The model incorporated all major signaling molecules, including dopamine- and cyclic AMP-regulated phosphoprotein with a molecular weight of 32 kDa (DARPP32), as well as AMPA receptor trafficking in the post-synaptic membrane. Simulations with dopamine and calcium inputs reproduced dopamine- and calcium-dependent plasticity. Further in silico experiments revealed that the positive feedback loop consisted of protein kinase A (PKA), protein phosphatase 2A (PP2A), and the phosphorylation site at threonine 75 of DARPP-32 (Thr75) served as the major switch for inducing LTD and LTP. The present model elucidated the mechanisms involved in bidirectional regulation of corticostriatal synapses and will allow for further exploration into causes and therapies for dysfunctions such as drug addiction."
Nakano T, Doi T, Yoshimoto J, Doya K (2010) A kinetic model of dopamine- and calcium-dependent striatal synaptic plasticity.
PLoS Comput Biol
(Click on a link to find other models with that property)
Neostriatum spiny direct pathway neuron;
Nakano, Takashi [nakano.takashi at gmail.com];
for information about:
Neostriatum spiny direct pathway neuron
File not selected
<- Select file from this column.
Loading data, please wait...
Questions, comments, problems? Email the
How to cite ModelDB
© This site is Copyright 2018 Shepherd Lab, Yale University