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Prediction for the presence of voltage-gated Ca2+ channels in myelinated central axons (Brown 2003)
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"The objective of this current study was to investigate whether voltage gated Ca(2+) channels are present on axons of the adult rat optic nerve (RON). Simulations of axonal excitability using a Hodgkin-Huxley based one-compartment model incorporating I(Na), I(K) and leak currents were used to predict conditions under which the potential contribution of a Ca(2+) current to an evoked action potential could be measured. ... , as predicted by the simulation, reducing the repolarizing effect of I(K) by adding the K(+) channel blocker 4-AP revealed a Ca(2+) component on the repolarizing phase of the action potential that was blocked by the Ca(2+) channel inhibitor nifedipine."
Brown AM (2003) A modeling study predicts the presence of voltage gated Ca2+ channels on myelinated central axons.
Comput Methods Programs Biomed
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Axonal Action Potentials;
Wu, Sheng-Nan [snwu at mail.ncku.edu.tw];
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