Global structure, robustness, and modulation of neuronal models (Goldman et al. 2001)

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Accession:127878
"The electrical characteristics of many neurons are remarkably robust in the face of changing internal and external conditions. At the same time, neurons can be highly sensitive to neuromodulators. We find correlates of this dual robustness and sensitivity in a global analysis of the structure of a conductance-based model neuron. ..."
Reference:
1 . Goldman MS, Golowasch J, Marder E, Abbott LF (2001) Global structure, robustness, and modulation of neuronal models. J Neurosci 21:5229-38 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Stomatogastric ganglion;
Cell Type(s):
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; I K,Ca; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: C or C++ program;
Model Concept(s): Bursting; Temporal Pattern Generation; Phase Response Curves;
Implementer(s): Goldman, Mark [msgoldman at ucdavis.edu];
Search NeuronDB for information about:  I Na,t; I L high threshold; I T low threshold; I A; I K; I K,Ca; I Potassium;
; CLW file contains information for the MFC ClassWizard

[General Info]
Version=1
LastClass=CNeuronPage
LastTemplate=CDialog
NewFileInclude1=#include "stdafx.h"
NewFileInclude2=#include "ZhengModel.h"
LastPage=0

ClassCount=11
Class1=CZhengModelApp
Class2=CZhengModelDoc
Class3=CZhengModelView
Class4=CMainFrame

ResourceCount=7
Resource1=IDD_DISPLAYPAGE
Resource2=IDD_NEURONPAGE
Resource3=IDR_ZHENGMTYPE
Class5=CAboutDlg
Class6=CChildFrame
Class7=CTabCtrls
Resource4=IDD_RUNPAGE
Resource5=IDR_MAINFRAME
Class8=CDisplayPage
Class9=CNeuronPage
Class10=CRunPage
Resource6=IDD_ABOUTBOX
Class11=CPlotsDialog
Resource7=IDD_PLOTSDIALOG

[CLS:CZhengModelApp]
Type=0
HeaderFile=ZhengModel.h
ImplementationFile=ZhengModel.cpp
Filter=N

[CLS:CZhengModelDoc]
Type=0
HeaderFile=ZhengModelDoc.h
ImplementationFile=ZhengModelDoc.cpp
Filter=N
BaseClass=CDocument
VirtualFilter=DC

[CLS:CZhengModelView]
Type=0
HeaderFile=ZhengModelView.h
ImplementationFile=ZhengModelView.cpp
Filter=W
BaseClass=CView
VirtualFilter=VWC
LastObject=CZhengModelView

[CLS:CMainFrame]
Type=0
HeaderFile=MainFrm.h
ImplementationFile=MainFrm.cpp
Filter=T
BaseClass=CMDIFrameWnd
VirtualFilter=fWC
LastObject=CMainFrame


[CLS:CChildFrame]
Type=0
HeaderFile=ChildFrm.h
ImplementationFile=ChildFrm.cpp
Filter=M

[CLS:CAboutDlg]
Type=0
HeaderFile=ZhengModel.cpp
ImplementationFile=ZhengModel.cpp
Filter=D
LastObject=CAboutDlg

[DLG:IDD_ABOUTBOX]
Type=1
Class=CAboutDlg
ControlCount=4
Control1=IDC_STATIC,static,1342177283
Control2=IDC_STATIC,static,1342308480
Control3=IDC_STATIC,static,1342308352
Control4=IDOK,button,1342373889

[MNU:IDR_MAINFRAME]
Type=1
Class=CMainFrame
Command1=ID_FILE_NEW
Command2=ID_FILE_OPEN
Command3=ID_FILE_PRINT_SETUP
Command4=ID_FILE_MRU_FILE1
Command5=ID_APP_EXIT
Command6=ID_VIEW_TOOLBAR
Command7=ID_VIEW_STATUS_BAR
Command8=ID_APP_ABOUT
CommandCount=8

[TB:IDR_MAINFRAME]
Type=1
Class=CMainFrame
Command1=ID_FILE_NEW
Command2=ID_FILE_OPEN
Command3=ID_FILE_SAVE
Command4=ID_EDIT_CUT
Command5=ID_EDIT_COPY
Command6=ID_EDIT_PASTE
Command7=ID_FILE_PRINT
Command8=ID_APP_ABOUT
CommandCount=8

[MNU:IDR_ZHENGMTYPE]
Type=1
Class=CZhengModelView
Command1=ID_FILE_NEW
Command2=ID_FILE_OPEN
Command3=ID_FILE_CLOSE
Command4=ID_FILE_SAVE
Command5=ID_FILE_SAVE_AS
Command6=ID_FILE_PRINT
Command7=ID_FILE_PRINT_PREVIEW
Command8=ID_FILE_PRINT_SETUP
Command9=ID_FILE_MRU_FILE1
Command10=ID_APP_EXIT
Command11=ID_EDIT_UNDO
Command12=ID_EDIT_CUT
Command13=ID_EDIT_COPY
Command14=ID_EDIT_PASTE
Command15=ID_VIEW_TOOLBAR
Command16=ID_VIEW_STATUS_BAR
Command17=ID_WINDOW_NEW
Command18=ID_WINDOW_CASCADE
Command19=ID_WINDOW_TILE_HORZ
Command20=ID_WINDOW_ARRANGE
Command21=ID_APP_ABOUT
CommandCount=21

[ACL:IDR_MAINFRAME]
Type=1
Class=CMainFrame
Command1=ID_FILE_NEW
Command2=ID_FILE_OPEN
Command3=ID_FILE_SAVE
Command4=ID_FILE_PRINT
Command5=ID_EDIT_UNDO
Command6=ID_EDIT_CUT
Command7=ID_EDIT_COPY
Command8=ID_EDIT_PASTE
Command9=ID_EDIT_UNDO
Command10=ID_EDIT_CUT
Command11=ID_EDIT_COPY
Command12=ID_EDIT_PASTE
Command13=ID_NEXT_PANE
Command14=ID_PREV_PANE
CommandCount=14

[CLS:CTabCtrls]
Type=0
HeaderFile=TabCtrls.h
ImplementationFile=TabCtrls.cpp
BaseClass=CPropertySheet
Filter=W
LastObject=CTabCtrls

[DLG:IDD_RUNPAGE]
Type=1
Class=CRunPage
ControlCount=38
Control1=IDC_STATIC,static,1342308352
Control2=IDC_DTMIN_EDIT,edit,1350631552
Control3=IDC_STATIC,static,1342308352
Control4=IDC_TMAX_EDIT,edit,1350631552
Control5=IDC_STATIC,static,1342308352
Control6=IDC_SAVE_RADIO,button,1342308361
Control7=IDC_SAVE_RADIOdummy,button,1342177289
Control8=IDC_STATIC,static,1342308352
Control9=IDC_DISPLAY_RADIO,button,1342308361
Control10=IDC_DISPLAY_RADIOdummy,button,1342177289
Control11=IDC_STATIC,static,1342308352
Control12=IDC_MAX_INJECT_SOMA_EDIT,edit,1350631552
Control13=IDC_STATIC,static,1342177280
Control14=IDC_INJECT_ON_EDIT,edit,1350631552
Control15=IDC_STATIC,static,1342177280
Control16=IDC_INJECT_OFF_EDIT,edit,1350631552
Control17=IDC_RUN_BUTTON,button,1342177280
Control18=IDC_STATIC,static,1342308352
Control19=IDC_STATIC,static,1342308352
Control20=IDC_STATIC,static,1342308352
Control21=IDC_STATIC,static,1342308352
Control22=IDC_STATIC,static,1342308352
Control23=IDC_END_RUN_BUTTON,button,1342242816
Control24=IDC_PAUSE_BUTTON,button,1342242816
Control25=IDC_MAX_INJECT_HILLOCK_EDIT,edit,1350631552
Control26=IDC_STATIC,static,1342308352
Control27=IDC_STATIC,static,1342308352
Control28=IDC_STATIC,static,1342308352
Control29=IDC_DTMAX_EDIT,edit,1350631552
Control30=IDC_STATIC,static,1342308352
Control31=IDC_APPLY_BUTT,button,1342242817
Control32=IDC_STATIC,static,1342177280
Control33=IDC_INJECT_ON_EDIT2,edit,1350631552
Control34=IDC_STATIC,static,1342308352
Control35=IDC_STATIC,static,1342308352
Control36=IDC_MAX_INJECT_SOMA_EDIT2,edit,1350631552
Control37=IDC_STATIC,static,1342308352
Control38=IDC_MAX_INJECT_HILLOCK_EDIT2,edit,1350631552

[DLG:IDD_NEURONPAGE]
Type=1
Class=CNeuronPage
ControlCount=114
Control1=IDC_RESISTIVITY_EDIT,edit,1350631552
Control2=IDC_COMPART_COMBO,combobox,1344339971
Control3=IDC_C_EDIT,edit,1350631552
Control4=IDC_RADIUS_EDIT,edit,1350631552
Control5=IDC_LENGTH_EDIT,edit,1350631552
Control6=IDC_INIT_V_EDIT,edit,1350631552
Control7=IDC_INIT_Ca_EDIT,edit,1350631552
Control8=IDC_CHAN_COMBO,combobox,1344339971
Control9=IDC_E_EDIT,edit,1350631552
Control10=IDC_CHAN_NUM_M_EDIT,edit,1350631552
Control11=IDC_CHAN_NUM_H_EDIT,edit,1350631552
Control12=IDC_SENS_COMBO,combobox,1344339971
Control13=IDC_SENS_VALUEMAX_EDIT,edit,1350631552
Control14=IDC_SENS_TAU_M_EDIT,edit,1350631552
Control15=IDC_SENS_TAU_H_EDIT,edit,1350631552
Control16=IDC_SENS_Z_M_EDIT,edit,1350631552
Control17=IDC_SENS_Z_H_EDIT,edit,1350631552
Control18=IDC_SENS_NUM_M_EDIT,edit,1350631552
Control19=IDC_SENS_NUM_H_EDIT,edit,1350631552
Control20=IDC_Leak_GMAX0_EDIT,edit,1350631552
Control21=IDC_Na_GMAX0_EDIT,edit,1350631552
Control22=IDC_CaT_GMAX0_EDIT,edit,1350631552
Control23=IDC_CaP_GMAX0_EDIT,edit,1350631552
Control24=IDC_A_GMAX0_EDIT,edit,1350631552
Control25=IDC_KCa_GMAX0_EDIT,edit,1350631552
Control26=IDC_Kd_GMAX0_EDIT,edit,1350631552
Control27=IDC_h_GMAX0_EDIT,edit,1350631552
Control28=IDC_DC_TARGET_EDIT,edit,1350631552
Control29=IDC_SLOW_TARGET_EDIT,edit,1350631552
Control30=IDC_FAST_TARGET_EDIT,edit,1350631552
Control31=IDC_APPLY_BUTT,button,1342242817
Control32=IDC_STATIC,static,1342308352
Control33=IDC_STATIC,button,1342177287
Control34=IDC_STATIC,static,1342308352
Control35=IDC_REMOVE_CHAN_BUTT,button,1342242816
Control36=IDC_STATIC,static,1342308352
Control37=IDC_STATIC,static,1342308352
Control38=IDC_STATIC,static,1342308352
Control39=IDC_STATIC,static,1342308352
Control40=IDC_STATIC,static,1342308352
Control41=IDC_STATIC,static,1342308352
Control42=IDC_STATIC,static,1342308352
Control43=IDC_STATIC,static,1342308352
Control44=IDC_STATIC,static,1342308352
Control45=IDC_STATIC,static,1342308352
Control46=IDC_STATIC,static,1342308352
Control47=IDC_STATIC,static,1342308352
Control48=IDC_STATIC,button,1342177287
Control49=IDC_STATIC,static,1342308352
Control50=IDC_STATIC,static,1342308352
Control51=IDC_STATIC,static,1342308352
Control52=IDC_AXIAL_CONDUCT_EDIT,edit,1484849280
Control53=IDC_AREA_EDIT,edit,1484849280
Control54=IDC_STATIC,static,1342308352
Control55=IDC_STATIC,static,1342308352
Control56=IDC_STATIC,static,1342308352
Control57=IDC_STATIC,static,1342308352
Control58=IDC_STATIC,static,1342308352
Control59=IDC_STATIC,static,1342308352
Control60=IDC_STATIC,button,1342177287
Control61=IDC_STATIC,static,1342308352
Control62=IDC_STATIC,static,1342308352
Control63=IDC_STATIC,static,1342308352
Control64=IDC_STATIC,static,1342308352
Control65=IDC_STATIC,static,1342308352
Control66=IDC_STATIC,static,1342308352
Control67=IDC_STATIC,static,1342308352
Control68=IDC_STATIC,static,1342308352
Control69=IDC_STATIC,static,1342308352
Control70=IDC_STATIC,static,1342308352
Control71=IDC_STATIC,static,1342308352
Control72=IDC_STATIC,static,1342308352
Control73=IDC_STATIC,static,1342308352
Control74=IDC_STATIC,static,1342308352
Control75=IDC_STATIC,button,1342177287
Control76=IDC_STATIC,static,1342308352
Control77=IDC_STATIC,static,1342308352
Control78=IDC_STATIC,static,1342308352
Control79=IDC_STATIC,static,1342308352
Control80=IDC_STATIC,static,1342308352
Control81=IDC_STATIC,static,1342308352
Control82=IDC_STATIC,static,1342308352
Control83=IDC_REMOVE_SENS_BUTT,button,1342373888
Control84=IDC_STATIC,static,1342308352
Control85=IDC_STATIC,static,1342308352
Control86=IDC_STATIC,static,1342308352
Control87=IDC_STATIC,button,1342177287
Control88=IDC_STATIC,static,1342308352
Control89=IDC_STATIC,static,1342308352
Control90=IDC_STATIC,static,1342308352
Control91=IDC_Leak_GMAX_STATIC,static,1342312460
Control92=IDC_Na_GMAX_STATIC,static,1342312460
Control93=IDC_h_GMAX_STATIC,static,1342312460
Control94=IDC_CaT_GMAX_STATIC,static,1342312460
Control95=IDC_CaP_GMAX_STATIC,static,1342312460
Control96=IDC_A_GMAX_STATIC,static,1342312460
Control97=IDC_KCa_GMAX_STATIC,static,1342312460
Control98=IDC_Kd_GMAX_STATIC,static,1342312460
Control99=IDC_DC_VALUE_STATIC,static,1342312460
Control100=IDC_SLOW_VALUE_STATIC,static,1342312460
Control101=IDC_FAST_VALUE_STATIC,static,1342312460
Control102=IDC_STATIC,button,1342177287
Control103=IDC_STATIC,static,1342308352
Control104=IDC_SYN_COMBO,combobox,1344339971
Control105=IDC_REMOVE_SYN_BUTT,button,1342242816
Control106=IDC_STATIC,static,1342308352
Control107=IDC_STATIC,static,1342308352
Control108=IDC_STATIC,static,1342308352
Control109=IDC_STATIC,static,1342308352
Control110=IDC_STATIC,static,1342308352
Control111=IDC_STATIC,static,1342308352
Control112=IDC_SYN_E_EDIT,edit,1350631552
Control113=IDC_SYN_TAUDECAY_EDIT,edit,1350631552
Control114=IDC_SYN_GSTEP_EDIT,edit,1350631552

[DLG:IDD_DISPLAYPAGE]
Type=1
Class=CDisplayPage
ControlCount=29
Control1=IDC_STATIC,static,1342308352
Control2=IDC_STATIC,static,1342308352
Control3=IDC_STATIC,static,1342308352
Control4=IDC_STATIC,static,1342308352
Control5=IDC_STATIC,static,1342308352
Control6=IDC_STATIC,static,1342308352
Control7=IDC_STATIC,static,1342308352
Control8=IDC_COMBO1,combobox,1344340226
Control9=IDC_GRAPH1_COMBO,combobox,1344339970
Control10=IDC_COMBO3,combobox,1344340226
Control11=IDC_COMBO4,combobox,1344340226
Control12=IDC_COMBO5,combobox,1344340226
Control13=IDC_COMBO6,combobox,1344340226
Control14=IDC_NUM_PLOTS_EDIT,edit,1350631552
Control15=IDC_STATIC,static,1342308352
Control16=IDC_STATIC,static,1342308352
Control17=IDC_MIN1_EDIT,edit,1350631552
Control18=IDC_MAX1_EDIT,edit,1350631552
Control19=IDC_MIN2_EDIT,edit,1350631552
Control20=IDC_MAX2_EDIT,edit,1350631552
Control21=IDC_MIN3_EDIT,edit,1350631552
Control22=IDC_MAX3_EDIT,edit,1350631552
Control23=IDC_MIN4_EDIT,edit,1350631552
Control24=IDC_MAX4_EDIT,edit,1350631552
Control25=IDC_MIN5_EDIT,edit,1350631552
Control26=IDC_MAX5_EDIT,edit,1350631552
Control27=IDC_MIN6_EDIT,edit,1350631552
Control28=IDC_MAX6_EDIT,edit,1350631552
Control29=IDC_APPLY_BUTT,button,1342242816

[CLS:CDisplayPage]
Type=0
HeaderFile=DisplayPage.h
ImplementationFile=DisplayPage.cpp
BaseClass=CPropertyPage
Filter=D
LastObject=CDisplayPage
VirtualFilter=idWC

[CLS:CNeuronPage]
Type=0
HeaderFile=NeuronPage.h
ImplementationFile=NeuronPage.cpp
BaseClass=CPropertyPage
Filter=D
LastObject=IDC_REMOVE_SYN_BUTT
VirtualFilter=idWC

[CLS:CRunPage]
Type=0
HeaderFile=RunPage.h
ImplementationFile=RunPage.cpp
BaseClass=CPropertyPage
Filter=D
LastObject=CRunPage
VirtualFilter=idWC

[CLS:CPlotsDialog]
Type=0
HeaderFile=PlotsDialog.h
ImplementationFile=PlotsDialog.cpp
BaseClass=CDialog
Filter=D
LastObject=CPlotsDialog
VirtualFilter=dWC

[DLG:IDD_PLOTSDIALOG]
Type=1
Class=CPlotsDialog
ControlCount=1
Control1=IDC_PLOTSPICTURE,static,1342308358


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