CA1 stratum radiatum interneuron multicompartmental model (Katona et al. 2011)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:136176
The model examines dendritic NMDA-spike generation and propagation in the dendrites of CA1 stratum radiatum interneurons. It contains NMDA-channels in a clustered pattern on a dendrite and K-channels. The simulation shows the whole NMDA spike and the rising phase of the traces in separate windows.
Reference:
1 . Katona G, Kaszas A, Turi GF, Hajos N, Tamas G, Vizi ES, Rozsa B (2011) Roller Coaster Scanning reveals spontaneous triggering of dendritic spikes in CA1 interneurons. Proc Natl Acad Sci U S A 108:2148-53 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 stratum radiatum interneuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models;
Implementer(s): Rozsa, Balazs ;
Search NeuronDB for information about:  NMDA; I Na,t; I K;
This is the readme file for the NEURON simulation demonstrating NMDA spikes in interneurons

Instructions to run the model under Windows Xp or Win7:

1. Start mknrndll
2. Select as working directory the folder "Katona_et_al"
3. press the button "Make nrnmech.dll"
4. start Neuron
5. Select as working directory the folder "Katona_et_al"
6. type Enter
7. copy the following line to oc> command prompt: load_file("basal.hoc")
8. Please remove nmda synapses one by one from the PointProcessGroupManager window using the remove button

Graph[1] demonstrates NMDA spikes in a reconstructed CA1 stratum radiatum interneuron
Graph[2] shows the enlarged view of the initiation phase of the spike

Loading data, please wait...