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Myelinated nerve fibre myelin resistance dependent on extracellular K+ level (Brazhe et al. 2010)
 
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Model Information
Model File
Citations
Accession:
136296
Excitation leads to rise in paranodal [K]e under the myelin. This causes structural changes in myelin structure and resistance. Current model aims to simulate this aspect. This is a space-clamped model of a double-cable nerve fibre.
Reference:
1 .
Brazhe AR, Maksimov GV, Mosekilde E, Sosnovtseva O (2010) Excitation block in a nerve fibre model owing to potassium-dependent changes in myelin resistance
Journal of Interface Focus
1(1)
:86-100
Model Information
(Click on a link to find other models with that property)
Model Type:
Extracellular;
Brain Region(s)/Organism:
Cell Type(s):
Myelinated neuron;
Channel(s):
I Na,p;
I Na,t;
I K;
I K,leak;
I_Ks;
Na/K pump;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
Lua;
Model Concept(s):
Intermittent block;
Implementer(s):
Brazhe, Alexey [brazhe at gmail.com];
Search NeuronDB
for information about:
I Na,p
;
I Na,t
;
I K
;
I K,leak
;
I_Ks
;
Na/K pump
;
/
myelin-resistance-intermittent-block
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