Globus pallidus neuron models with differing dendritic Na channel expression (Edgerton et al., 2010)

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A set of 9 multi-compartmental rat GP neuron models (585 compartments) differing only in their expression of dendritic fast sodium channels were compared in their synaptic integration properties. Dendritic fast sodium channels were found to increase the importance of distal synapses (both excitatory AND inhibitory), increase spike timing variability with in vivo-like synaptic input, and make the model neurons highly sensitive to clustered synchronous excitation.
1 . Edgerton JR, Hanson JE, Gunay C, Jaeger D (2010) Dendritic sodium channels regulate network integration in globus pallidus neurons: a modeling study. J Neurosci 30:15146-59 [PubMed]
2 . Edgerton JR, Jaeger D (2011) Dendritic Sodium Channels Promote Active Decorrelation and Reduce Phase Locking to Parkinsonian Input Oscillations in Model Globus Pallidus Neurons J. Neurosci. 31:10919-10936
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Axon; Synapse; Channel/Receptor; Dendrite;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Globus pallidus neuron;
Channel(s): I Na,p; I Na,t; I A; I K; I h; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s): GabaA; AMPA;
Gene(s): Kv4.1 KCND1;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Coincidence Detection; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Synaptic Integration;
Implementer(s): Gunay, Cengiz [cgunay at]; Edgerton, Jeremy R. [jedgert at]; Hanson, Jesse E.; Jaeger, Dieter [djaeger at];
Search NeuronDB for information about:  GabaA; AMPA; I Na,p; I Na,t; I A; I K; I h; I K,Ca; I Calcium; Gaba; Glutamate;
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