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Globus pallidus neuron models with differing dendritic Na channel expression (Edgerton et al., 2010)
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A set of 9 multi-compartmental rat GP neuron models (585 compartments) differing only in their expression of dendritic fast sodium channels were compared in their synaptic integration properties. Dendritic fast sodium channels were found to increase the importance of distal synapses (both excitatory AND inhibitory), increase spike timing variability with in vivo-like synaptic input, and make the model neurons highly sensitive to clustered synchronous excitation.
Edgerton JR, Hanson JE, Gunay C, Jaeger D (2010) Dendritic sodium channels regulate network integration in globus pallidus neurons: a modeling study.
Edgerton JR, Jaeger D (2011) Dendritic Sodium Channels Promote Active Decorrelation and Reduce Phase Locking to Parkinsonian Input Oscillations in Model Globus Pallidus Neurons
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Neuron or other electrically excitable cell;
Globus pallidus neuron;
Action Potential Initiation;
Dendritic Action Potentials;
Influence of Dendritic Geometry;
Detailed Neuronal Models;
Gunay, Cengiz [cgunay at emory.edu];
Edgerton, Jeremy R. [jedgert at emory.edu];
Hanson, Jesse E.;
Jaeger, Dieter [djaeger at emory.edu];
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